|1.||Lin, Yun-Wei: 6 articles (09/2011 - 05/2008)|
|2.||Sung, Patrick: 5 articles (07/2015 - 11/2007)|
|3.||Ko, Jen-Chung: 5 articles (09/2011 - 05/2008)|
|4.||Wang, Lyu-Han: 5 articles (09/2009 - 05/2008)|
|5.||Hong, Jhao-Hao: 5 articles (09/2009 - 05/2008)|
|6.||Wiese, Claudia: 4 articles (07/2015 - 11/2007)|
|7.||Venkitaraman, Ashok R: 4 articles (07/2011 - 09/2003)|
|8.||Connell, Philip P: 3 articles (07/2014 - 05/2006)|
|9.||Dray, Eloïse: 3 articles (10/2011 - 11/2007)|
|10.||Tsai, Miaw-Sheue: 3 articles (10/2011 - 11/2007)|
01/01/2015 - "Several studies have identified that stabilization of the cancer genome in HR deficient cells can be achieved by overexpression of the recombinase RAD51. "
05/01/2006 - "High levels of RAD51 protein expression have been reported in number of human cancer cell lines, and studies suggest that RAD51 overexpression can increase cellular resistance to radiation and some chemotherapeutic drugs. "
01/01/2015 - "RAD51 recombinase plays a critical role for cancer cell proliferation and survival. "
01/01/2015 - "Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase."
08/01/2014 - "Next, PALB2 interacts with BRCA2, which is a tumor suppressor, and with the RAD51 recombinase. "
|2.||Breast Neoplasms (Breast Cancer)
07/06/2012 - "A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization."
01/01/2009 - "Bloom (BLM) helicase directly interacts with RAD51 recombinase, which is involved in regulating HR, and it is thus of particular interest to examine whether this interaction is associated with breast cancer susceptibility. "
01/01/2007 - "The breast cancer susceptibility gene BRCA2 encodes a critical accessory protein that interacts with the RAD51 recombinase and this interaction fluctuates during the cell cycle. "
06/15/2001 - "The protein products of the hereditary breast cancer susceptibility genes, BRCA1 and BRCA2, interact with the Rad51 protein, a central component of homologous repair pathways. "
01/01/2015 - "Mutations in the breast cancer susceptibility gene BRCA2 leading to the failure of interactions with the recombinase RAD51 are associated with an increased risk of cancer in humans. "
|3.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
|4.||Head and Neck Neoplasms (Head and Neck Cancer)
05/01/2006 - "In this study, RAD51 protein levels were quantified by immunohistochemistry in tumor samples from twelve head and neck cancer patients who received identical treatment with induction chemotherapy (paclitaxel and carboplatinum) followed by radiation therapy given concurrently with additional chemotherapy (paclitaxel, fluorouracil, hydroxyurea). "
03/11/2015 - "Even though homologous recombination (HR) is ascribed to maintain genome stability, this eukaryote exploits this potent mechanism driven by the Rad51 recombinase to form beneficial extrachromosomal circular amplicons. "
11/09/2007 - "Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement."
01/15/2004 - "These data provide a link between elevated Rad51 protein levels, genome instability, and tumor progression."
02/27/2003 - "The RAD51 recombinase interacts directly with the breast cancer-associated tumour suppressor BRCA2, an interaction that is required for normal recombination proficiency, radiation resistance and genome stability. "
02/15/2002 - "We deleted this Brca2 COOH-terminal domain because it interacts directly with the Rad51 protein, contains a nuclear localization signal, and is required to maintain genomic stability in response to various types of DNA damage. "
|2.||vorinostat (suberoylanilide hydroxamic acid)
|7.||DNA (Deoxyribonucleic Acid)
|8.||Proteins (Proteins, Gene)
|1.||Drug Therapy (Chemotherapy)
|4.||Heterologous Transplantation (Xenotransplantation)