Oxidized LDL Receptors

A group of cell-surface receptors for oxidatively modified LOW-DENSITY LIPOPROTEINS. The group includes certain SCAVENGER RECEPTORS that contribute to the pathogenesis of ATHEROSCLEROSIS by uptake of oxidized LDL.
Also Known As:
Receptors, Oxidized LDL; Ox-LDL Receptor; Oxidized LDL Receptor; Receptor, LDL, Oxidized; Receptor, Oxidized LDL; LDL Receptor, Oxidized; LDL Receptors, Oxidized; Ox LDL Receptor; Receptor, Ox-LDL
Networked: 43 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results


1. Sawamura, Tatsuya: 8 articles (10/2012 - 09/2002)
2. Mehta, Jawahar L: 7 articles (12/2012 - 03/2003)
3. Yasuda, Tadashi: 4 articles (04/2012 - 09/2002)
4. Nakamura, Takashi: 4 articles (04/2012 - 09/2002)
5. Wang, Xianwei: 3 articles (12/2012 - 01/2011)
6. Khaidakov, Magomed: 3 articles (12/2012 - 01/2011)
7. Mitra, Sona: 3 articles (12/2012 - 01/2011)
8. Fujita, Yoshiko: 3 articles (10/2012 - 01/2006)
9. Sawamura, T: 3 articles (10/2010 - 02/2001)
10. Li, Dayuan: 3 articles (07/2010 - 03/2003)

Related Diseases

1. Atherosclerosis
2. Reperfusion Injury
3. Arthritis (Polyarthritis)
4. Inflammation
12/01/2012 - "Ischemic myocardium exhibits inflammation, local angiotensin II (Ang II) generation and up-regulation of LOX-1, a lectin-like ox-LDL receptor. "
06/09/2006 - "There was evidence of intense oxidative stress (nitrotyrosine staining), inflammation (CD68 staining), and expression of adhesion molecules and the ox-LDL receptor LOX-1 (gene array analysis) in the atherosclerotic tissues. "
06/01/2014 - "Molecular mechanism dissection suggested that AR in monocytes/macrophages upregulated the tumor necrosis factor-α, integrin β2, and lectin-type oxidized LDL receptor 1 molecules that are involved in 3 major inflammation-related processes in atherosclerosis, including monocytes/macrophages migration and adhesion to human umbilical vein ECs, and subsequent foam cell formation. "
01/01/2008 - "Full genome microarrays of brains reflected inflammation causing neuronal damage (Gfap), effects on host cell protein processing (ubiquitin ligase), synapse remodeling (Complement 1q), and also increased expression of PD-1L (a ligand that allows persistent LCMV brain infection) and CD 36 (a fatty acid translocase and oxidized LDL receptor that mediates innate immune response to beta amyloid which is associated with pro-inflammation in Alzheimer's disease). "
05/01/2015 - "The effects of RSV were closely related to hypolipidemia (decrease in the levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol combined with the expression of the lectin-like ox-LDL receptor and increase in high-density lipoprotein cholesterol), antioxidation (decrease in MDA levels and increase in SOD and GPx activities), and anti-inflammation (downregulation of the expression of IL-1β, intracellular adhesion molecule-1, and monocyte chemotactic protein-1). "
5. Alzheimer Disease (Alzheimer's Disease)

Related Drugs and Biologics

1. oxidized low density lipoprotein
2. Zymosan
3. Scavenger Receptors (Scavenger Receptor)
4. Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
5. Cysteine-Rich Protein 61
6. Osteopontin
7. Adiponectin
8. Class E Scavenger Receptors (Lectin Like Oxidized Low Density Lipoprotein Receptor 1)
9. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10. Ubiquitin