1-Acylglycerol-3-Phosphate O-Acyltransferase (1 Acylglycerol 3 Phosphate O Acyltransferase)

An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. This enzyme has alpha, beta, gamma, delta and epsilon subunits.

Also Known As:

1 Acylglycerol 3 Phosphate O Acyltransferase; 1-AGP-Acyltransferase; 1-Acylglycerol Phosphate Acyltransferase 2; 1-Acylglycerophosphate Acyltransferase; 1-Palmitylglycerol 3-Phosphate Acyltransferase; Acyl CoA-1-Acyl-Syn-Glycerol-3-Phosphate O-Acyltransferase; Acyl CoA-Monoacylglycerophosphateacyltransferase; Acyl Coenzyme A-Monacylglycerophosphateacyltransferase; 1 AGP Acyltransferase; 1 Acylglycerol Phosphate Acyltransferase 2; 1 Acylglycerophosphate Acyltransferase; 1 Palmitylglycerol 3 Phosphate Acyltransferase; 3-Phosphate Acyltransferase, 1-Palmitylglycerol; A-Monacylglycerophosphateacyltransferase, Acyl Coenzyme; Acyl CoA 1 Acyl Syn Glycerol 3 Phosphate O Acyltransferase; Acyl CoA Monoacylglycerophosphateacyltransferase; Acyl Coenzyme A Monacylglycerophosphateacyltransferase; Acyltransferase, 1-Acylglycerophosphate; Acyltransferase, 1-Palmitylglycerol 3-Phosphate; CoA-1-Acyl-Syn-Glycerol-3-Phosphate O-Acyltransferase, Acyl; CoA-Monoacylglycerophosphateacyltransferase, Acyl; Coenzyme A-Monacylglycerophosphateacyltransferase, Acyl; O-Acyltransferase, 1-Acylglycerol-3-Phosphate; O-Acyltransferase, Acyl CoA-1-Acyl-Syn-Glycerol-3-Phosphate

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - 1-Acylglycerol-3-Phosphate O-Acyltransferase: 9
        Arabidopsis At1g75020 protein
        Arabidopsis At3g18850 protein
        Arabidopsis GPAT5 protein
        E coli plsC protein
        human ABHD5 protein
        human AGPAT1 protein
        human GPAT3 protein
        human LCLAT1 protein
        human MBOAT2 protein
        mouse Abhd5 protein
        mouse Agpat1 protein
        mouse Agpat4 protein
        mouse GPAT3 protein

Experts

1.	Agarwal, Anil K: 3 articles (10/2020 - 10/2003)
2.	Garg, Abhimanyu: 3 articles (10/2020 - 10/2003)
3.	O'Rahilly, Stephen: 2 articles (03/2015 - 10/2003)
4.	Agusa, Tetsuro: 1 article (06/2022)
5.	Eguchi, Akifumi: 1 article (06/2022)
6.	Iwata, Hisato: 1 article (06/2022)
7.	Kannan, Kurunthachalam: 1 article (06/2022)
8.	Kim, Eun-Young: 1 article (06/2022)
9.	Li, Lingyun: 1 article (06/2022)
10.	Nguyen, Hoa Thanh: 1 article (06/2022)

Related Diseases

1.	Insulin Resistance 11/06/2015 - "Mutations in 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) result in lipodystrophy, insulin resistance and diabetes. " 02/21/2014 - "In this study we examined the role of phosphatidic acid (PA) in hepatic glucose production (HGP) and development of hepatic insulin resistance in mice that lack 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2). "
2.	Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy) 10/01/2020 - "Biallelic loss of function variants in AGPAT2, encoding 1-acylglycerol-3-phosphate O-acyltransferase 2, cause congenital generalized lipodystrophy type 1, a disease characterized by near total loss of white adipose tissue and metabolic complications. " 03/01/2015 - "Disruption of the genes encoding either seipin or 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) causes severe congenital generalized lipodystrophy (CGL) in humans. " 12/01/2007 - "To analyze Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) and 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) gene variation in a Chinese boy with CGL and his family. " 10/01/2003 - "Recently, mutations in 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) and Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) genes were reported in pedigrees linked to chromosomes 9q34 and 11q13, respectively. "
3.	Mood Disorders (Mood Disorder) 08/01/2010 - "Decreased expression or modification was observed for complexin 1 (CPLX1), alpha-synuclein, parvalbumin, ribosomal protein large P2, prohibitin, nerve growth factor, beta subunit (NGFB), peroxiredoxin 6 (PRDX6), 1-acylglycerol-3-phosphate O-acyltransferase 2_predicted, cystatin B (CYTB) and lysosomal membrane glycoprotein 1. CPLX1, the most strongly regulated protein observed, mediates the fusion of cellular transport vesicles with their target membranes and has been implicated in the pathophysiology of mood disorders, as well as antidepressant action. "
4.	Hypertriglyceridemia 04/01/2022 - "We report CGL1 in two Saudi female siblings with lipoatrophy, diabetes mellitus, hypertriglyceridemia, steatohepatitis, and acanthosis due to very rare homozygous 1-acylglycerol-3-phosphate O-acyltransferase β (AGPAT2) genetic variant."
5.	Sarcoma (Soft Tissue Sarcoma) 06/20/2022 - "Palmitic acid and genes related to circadian rhythm, insulin responses, and lipid metabolism (e.g., 1-acylglycerol-3-phosphate O-acyltransferase 2 (Agpat2), B-cell CLL/lymphoma 10 (Bcl10), Cry1, Harvey rat sarcoma virus oncogene (Hras), and NLR family member X1 (Nlrx1)) were identified through DIABLO models as novel biomarkers of effects of BPA across two generations."

Related Drugs and Biologics

1.	Phosphatidic Acids (Phosphatidic Acid)
2.	Glucose (Dextrose)
3.	Cystatin B
4.	Peroxiredoxin VI
5.	Lysosomal Membrane Proteins
6.	alpha-Synuclein
7.	Nerve Growth Factor (NGF)
8.	Palmitic Acid (Hexadecanoic Acid)
9.	Biomarkers (Surrogate Marker)
10.	Ribosomal Proteins (Ribosomal Protein)