Neurturin

A glial cell line-derived neurotrophic factor ligand that is specific for the GFRA2 RECEPTOR. Neurturin is essential for the development of specific postganglionic parasympathetic NEURONS.

Also Known As:

Networked: 97 relevant articles (4 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bartus, Raymond T: 13 articles (01/2020 - 01/2007)
2.	Kordower, Jeffrey H: 10 articles (01/2020 - 05/2007)
3.	Herzog, Christopher D: 9 articles (01/2013 - 01/2007)
4.	Gasmi, Mehdi: 6 articles (04/2009 - 01/2007)
5.	Olanow, C Warren: 4 articles (01/2020 - 05/2008)
6.	Brown, Lamar: 4 articles (01/2013 - 04/2009)
7.	Li, Hongjun: 4 articles (01/2013 - 04/2003)
8.	Sun, Maosheng: 4 articles (01/2013 - 04/2003)
9.	Wilson, Alistair: 4 articles (10/2011 - 07/2007)
10.	Keast, Janet R: 4 articles (08/2010 - 05/2006)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 01/01/2017 - "The structural effect of neurturin (NRTN) on the nigrostriatal dopaminergic system in animals remains unknown, although NRTN has been shown to be effective in Parkinson's disease animal models. " 01/01/2023 - "Here, we performed post-mortem studies on two patients with advanced Parkinson's disease that survived 10 years following AAV-neurturin gene (Cere120) delivery to verify long-term effects of trophic factor neurturin. " 01/01/2023 - "Post-Mortem Studies of Neurturin Gene Therapy for Parkinson's Disease: Two Subjects with 10 Years CERE120 Delivery." 01/01/2020 - "Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson's disease." 12/01/2010 - "In an open-label phase 1 trial, gene delivery of the trophic factor neurturin via an adeno-associated type-2 vector (AAV2) was well tolerated and seemed to improve motor function in patients with advanced Parkinson's disease. "
2.	Chronic Pain 02/01/2007 - "GDNF and neurturin have shown promise in clinical trials of Parkinson's disease, and artemin is currently undergoing clinical trials for chronic pain treatment. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2000 - "Therefore, our results suggest that neurturin is a good candidate for the treatment of this neurodegenerative disorder." 01/01/2018 - "Neurturin (NRTN) provides trophic support to neurons and is considered a therapeutic agent for neurodegenerative diseases, such as Parkinson's disease. " 01/01/2020 - "Neurturin is a potent neurotrophic factor that has been investigated as a potential therapeutic agent for the treatment of neurodegenerative diseases, including Parkinson's disease, and, more recently, for the treatment of type II diabetes. " 01/01/2013 - "Advancing neurotrophic factors as treatments for age-related neurodegenerative diseases: developing and demonstrating "clinical proof-of-concept" for AAV-neurturin (CERE-120) in Parkinson's disease." 01/01/2014 - "GDAs(BMP) produce multiple agents of interest as treatments for PD and other neurodegenerative disorders, including BDNF, GDNF, neurturin and IGF1. "
4.	Pain (Aches) 01/01/2018 - "In this study, we explored roles for GDNF, neurturin, and artemin signaling in bone pain using male Sprague Dawley rats. " 01/01/2018 - "In addition, we have shown that inflammatory bone pain also involves activation and sensitization of nonpeptidergic neurons via GDNF/GFRα1 and neurturin/GFRα2 signaling pathways, and that sequestration of neurturin, but not GDNF, might be useful to treat inflammatory bone pain derived from activation of nonpeptidergic bone afferent neurons. " 01/01/2018 - "GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent Neurons and Contribute to Inflammatory Bone Pain." 12/01/2014 - "Visual analog scale pain scores significantly correlated with younger age, higher depression scores, increased expression of neurturin and decreased expression of transient receptor potential ankyrin 1 in the mucosa. " 01/01/2018 - "We have shown the first evidence of a role for GDNF, neurturin, and artemin in the activation and sensitization of bone afferent neurons, and that sequestering these ligands reduces pain behavior in a model of inflammatory bone pain. "
5.	Bipolar Disorder (Manic Depressive Psychosis) 10/01/2008 - "In this study, we examined the expression levels of the members of the glial cell line-derived neurotrophic factor (GDNF) family (GDNF, artemin (ARTN), neurturin, and persephin), brain-derived neurotrophic factor, nerve growth factor, neurotrophin-3 (NT-3), and neurotrophin-4 mRNAs by using quantitative real-time PCR method in peripheral blood cells of patients with major depressive and bipolar disorders in both a current depressive and a remissive states. "

Related Drugs and Biologics

1.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)
2.	Nerve Growth Factors (Neurotrophins)
3.	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
4.	Dopamine (Intropin)
5.	Ligands
6.	Brain-Derived Neurotrophic Factor (BDNF)
7.	persephin
8.	Nerve Growth Factor (NGF)
9.	Proteins (Proteins, Gene)
10.	Glial Cell Line-Derived Neurotrophic Factors (GDNF Family Ligands)

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Catheters
4.	Axotomy
5.	Intravenous Infusions