PTEN Phosphohydrolase (PTEN Phosphatase)

A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.

Also Known As:

PTEN Phosphatase; PTEN Protein; MMAC1 Protein; Mutated In Multiple Advanced Cancers 1 Protein; PTEN Protein Phosphatase; Phosphatase and Tensin Homologue on Chromosome Ten Protein; Phosphatase, PTEN; Phosphatase, PTEN Protein; Phosphohydrolase, PTEN; Protein Phosphatase, PTEN

Networked: 865 relevant articles (9 outcomes, 101 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eng, Charis: 19 articles (03/2015 - 05/2002)
2.	Lotan, Tamara L: 10 articles (01/2022 - 10/2011)
3.	De Marzo, Angelo M: 9 articles (01/2022 - 10/2011)
4.	Leslie, Nick R: 9 articles (04/2014 - 01/2004)
5.	Pandolfi, Pier Paolo: 9 articles (04/2014 - 10/2002)
6.	Pulido, Rafael: 8 articles (12/2019 - 08/2003)
7.	He, Lina: 6 articles (01/2021 - 02/2009)
8.	Evers, B Mark: 6 articles (04/2011 - 09/2002)
9.	Waite, Kristin A: 6 articles (01/2008 - 03/2003)
10.	Stiles, Bangyan L: 5 articles (01/2021 - 05/2010)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2017 - "Our studies revealed that VEGFR3 inhibition may be a pharmacological means to upregulate p53 and PTEN protein expression and improve the outcome of patients with p53- and PTEN-deficient tumors." 03/01/2016 - "In 238 patient tumors from the NCIC-CTG trial OV.16, PTEN protein expression was quantified by Automated QUantitative Analysis (AQUA). " 09/01/2008 - "Therefore the present study reveals that the C-terminus of PTEN plays a critical role in stabilizing PTEN via antagonizing NEDD4-1-induced PTEN protein decay; conversely, truncation of the PTEN C-terminus results in rapid NEDD4-1-mediated PTEN degradation, a possible mechanism accounting for attenuation of PTEN function by certain PTEN mutations in human cancers." 01/01/2008 - "A new study shows that microdeletions in PTEN, resulting in complete loss of PTEN protein, are signature lesions in these cancers, particularly those arising in BRCA1-mutation carriers." 10/19/2001 - "In this study, we demonstrate that expression of Bcl-2 in prostate tumors correlates with loss of the PTEN protein. "
2.	Endometrial Neoplasms (Endometrial Cancer) 08/09/2021 - "PTEN protein expression has role in predicting disease-free-interval in endometrioid endometrial carcinoma." 12/01/2004 - "Significance of PTEN alterations in endometrial carcinoma: a population-based study of mutations, promoter methylation and PTEN protein expression." 05/01/2004 - "Three different human endometrial cancer cell lines known to have wild-type PTEN (HEC 1-A) or a mutated inactive PTEN protein (RL 95-2 and Ishikawa) were used for these studies. " 03/11/2004 - "Three different human endometrial cancer cell lines known to have wild type PTEN (HEC 1-A) or a mutated inactive PTEN protein (RL 95-2 and Ishikawa) were used for these studies. " 09/01/2003 - "In the present study, we have used an endometrial cancer cell line known to possess wild-type PTEN (HEC-1-A) and two mutated inactive PTEN protein cell lines (RL-95-2 and Ishikawa) to investigate importance of PI 3-K/PTEN/Akt survival pathway in endometrial cancers. "
3.	Melanoma (Melanoma, Malignant) 01/01/2020 - "The goal of our study was to: (a) correlate PTEN expression with selected clinico-pathological variables, and assess its prognostic significance; (b) correlate molecular aberrations with PTEN expression to consider the utility of immunohistochemical analysis of PTEN protein expression for screening PTEN genetic alterations; (c) review the literature and evaluate the PTEN expression level in melanoma with respect to possible therapeutic targeting. " 05/01/2002 - "The only study which reports PTEN protein expression in melanoma focuses on cytoplasmic expression, mainly in metastatic samples. " 01/01/2023 - "The findings add to our understanding of potential molecular intratumoral heterogeneity in melanoma and the features associated with the loss of PTEN protein in this disease." 01/01/2023 - "We assessed a unique cohort of eight melanoma samples with focal loss of PTEN protein expression to understand the features and mechanisms of PTEN loss in this disease. " 11/01/2014 - "Loss of PTEN protein expression correlates significantly with decreased OS and time to MBM in stage IIIB/C melanoma patients with BRAF(V600) mutations. "
4.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2013 - "The aim of this study was to investigate the expression of MMP-7 and PTEN protein in colorectal cancer and explore its correlation with clinicopathological parameters. " 09/14/2022 - "The case #2 patient was diagnosed with colorectal carcinoma with proficient MMR and PTEN protein loss without PTEN alteration, as well as a high PD-L1 CPS (CPS = 10). " 04/08/2017 - "Conclusions: Loss of expression of PTEN protein may be an important molecular marker in predicting the occurrence and PTEN may be useful as a prognostic marker of colorectal carcinoma. " 04/01/2014 - "B7-H1 immunoreactivities were found in 54.5% (55/101) of the colorectal cancer tissues with no expression in the normal tissues, and the PTEN protein immunoreactivities were observed in 51.5% (52/101) of the colorectal cancer tissues and 72.3% (73/101) of the normal tissues. " 11/01/2013 - "PTEN phosphatase-independent maintenance of glandular morphology in a predictive colorectal cancer model system."
5.	Insulin Resistance 01/01/2020 - "Icariin treatment markedly reduced Aβ-enhanced PTEN protein levels, leading to an improvement in Aβ-induced insulin resistance. " 05/01/2008 - "The insulin resistance associated with glucotoxicity in our model reflects in part decreased availability of PtdIns(3,4,5)P3, which correlates with increased PTEN protein expression. " 02/01/2001 - "By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. " 01/01/2017 - "Copper increased insulin sensitivity by decreasing the level of phosphatase and tensin homolog (PTEN) protein. " 01/01/2021 - "In the current study, three experimental mouse models: high-fat diet, high-carbohydrate diet, and a genetic model of hepatic insulin resistance where the liver hyperinsulinemia signal is mimicked via hepatic deletion of Pten (phosphatase and tensin homolog deleted on chromosome 10), the negative regulator of the insulin/phosphatidylinositol 3-kinase signaling pathway, were used. "

Related Drugs and Biologics

1.	Tensins
2.	Proteins (Proteins, Gene)
3.	Biomarkers (Surrogate Marker)
4.	Lipids
5.	Cetuximab (Erbitux)
6.	Protein Isoforms (Isoforms)
7.	Azacitidine (5 Azacytidine)
8.	tanespimycin (17AAG)
9.	icariin
10.	thiamine triphosphorate (TTP)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Curettage
5.	Precision Medicine