|1.||Ruth, Peter: 7 articles (01/2014 - 07/2005)|
|2.||Sontheimer, Harald: 5 articles (07/2008 - 03/2002)|
|3.||Sausbier, Matthias: 4 articles (07/2010 - 07/2005)|
|4.||Sontheimer, H: 4 articles (07/2005 - 07/2000)|
|5.||Haddad, Gabriel G: 3 articles (04/2014 - 06/2007)|
|6.||Weiger, Thomas M: 3 articles (01/2013 - 10/2007)|
|7.||Nelson, Mark T: 3 articles (01/2012 - 09/2003)|
|8.||Barth, Alison L: 3 articles (12/2010 - 06/2008)|
|9.||Aldrich, Richard W: 3 articles (07/2010 - 08/2004)|
|10.||López-Barneo, José: 3 articles (04/2010 - 08/2002)|
01/01/2014 - "KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury."
09/15/2014 - "Indeed, the mitochondrial BK channels (mitoBK) have recently been shown to play a protective function against ischemia-reperfusion injury both in vitro and in animal models, although the exact mechanism of this protection is still under scrutiny. "
09/04/2015 - "The mitochondrial division inhibitor mdivi-1 attenuates spinal cord ischemia-reperfusion injury both in vitro and in vivo: Involvement of BK channels."
09/15/2014 - "This review describes recent developments of the increasing relevance of BK channels in hypoxia and ischemia-reperfusion injury. "
|2.||Myocardial Ischemia (Ischemic Heart Diseases)
06/01/2013 - "Since activators of BK channels expressed in cardiac mitochondria trigger protective effects in several models of myocardial ischemia/reperfusion (I/R), this work aimed to evaluate the potential cardioprotective effects of NAR and the involvement of mitochondrial BK channels. "
02/02/2001 - "Thus, reduced expression of MaxiK channels in aged coronary arteries would lead to a decreased vasodilating capacity and increased risk of coronary spasm and myocardial ischemia in older people."
11/25/2013 - "The present study investigated the effects of MA on BK channels in NG108-15 mouse neuroblastoma×rat glioma hybrid cells using whole-cell and cell-attached patch clamp techniques. "
07/15/2005 - "We show here that glioma BK channels are a downstream target of erbB2/neuregulin signaling. "
07/15/2005 - "Modulation of glioma BK channels via erbB2."
06/01/2003 - "We conclude that Itransient is generated by a mechanism related to the deactivation, and level of prior activation, of glioma BK channels. "
06/01/2003 - "We have previously demonstrated the expression of BK channels in human glioma cells. "
|4.||Overactive Urinary Bladder (Overactive Bladder)
05/01/2015 - "The novel BK channel opener, GoSlo-SR-5-130, is approximately fivefold more efficacious on BK channels with regulatory β subunits and may be a useful scaffold in the development of drugs to treat diseases such as overactive bladder."
09/15/2014 - "Modulation of UBSM BK channels can occur by directly or indirectly targeting their regulatory mechanisms, which has the potential to provide novel therapeutic approaches for bladder dysfunction, such as overactive bladder and detrusor underactivity. "
08/27/2004 - "BK channels are thought to have a particularly prominent role in urinary bladder smooth muscle function and therefore are candidate targets for overactive bladder therapy. "
08/27/2004 - "These results reveal a central role for BK channels in urinary bladder function and indicate that BK channel dysfunction leads to overactive bladder and urinary incontinence."
03/01/2007 - "Ion Channel Innovations has developed a gene transfer product, hMaxi-K, and has begun clinical trials to investigate the effect of increased expression of Maxi-K channels in the smooth muscle of the penis or bladder in patients with erectile dysfunction and those with overactive bladder. "
|5.||Dehydration (Water Stress)
08/14/2006 - "The aim of this study is to define the role of NO in the regulation of Ca(2+)-activated K(+) channels (BK channels) expression in the magnocellular system following dehydration. "
06/03/2011 - "Importantly, apical BK channels were found to be critical for the maintenance of adequate airway surface liquid volume because continuous inhibition of BK channels or knockdown of KCNMA1, the gene coding for the BK α subunit (KCNMA1), lead to airway surface dehydration and thus periciliary fluid height collapse revealed by low ciliary beat frequency that could be fully rescued by addition of apical fluid. "
08/14/2006 - "These results suggest that NO may enhance the expression of BK channels in the supraoptic nuclei and neural lobe of rats following dehydration."
01/10/2007 - "We previously found that increased nitric oxide synthase (NOS) activity in the supraoptic nuclei (SON) and neural lobe following osmotic stimulation and NO could regulate the expression of Ca(2+)-activated K(+) channel (BK channels) protein in the magnocellular system during dehydration. "
08/14/2006 - "In about 70% of these neurons, BK channels were co-localized in the same neuron, and their expression increased significantly during dehydration. "
|1.||Ion Channels (Ion Channel)
|3.||Myosin Light Chains (Myosin Essential Light Chain)
|7.||Adenosine Triphosphate (ATP)
|8.||Calcium-Activated Potassium Channels (Calcium-Activated Potassium Channel)
|10.||Ethanol (Ethyl Alcohol)
|1.||Drug Therapy (Chemotherapy)