Inhibitor of Apoptosis Proteins

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.
Also Known As:
Baculoviral Inhibitor Of Apoptosis Repeat Proteins; IAP Protein (Apoptosis); IAP1 Protein; IAP2 Protein; Inhibitor of Apoptosis 1 Protein; Inhibitor of Apoptosis 2 Protein; Inhibitor-Of-Apoptosis Protein; c-IAP1 Protein; c-IAP2 Protein; cIAP1 Protein; Apoptosis Proteins Inhibitor; Inhibitor Of Apoptosis Protein
Networked: 489 relevant articles (6 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Fulda, Simone: 9 articles (12/2015 - 01/2004)
2. Wang, Shaomeng: 9 articles (04/2014 - 02/2005)
3. Altieri, Dario C: 6 articles (04/2006 - 09/2002)
4. Sun, Haiying: 5 articles (04/2014 - 02/2005)
5. Sato, Noriyuki: 5 articles (11/2009 - 02/2005)
6. Hirohashi, Yoshihiko: 5 articles (11/2009 - 02/2005)
7. Torigoe, Toshihiko: 5 articles (11/2009 - 02/2005)
8. Yang, Chao-Yie: 4 articles (04/2014 - 02/2005)
9. Lu, Jianfeng: 4 articles (04/2014 - 11/2008)
10. Fulda, S: 4 articles (01/2014 - 03/2007)

Related Diseases

1. Neoplasms (Cancer)
2. Pancreatic Neoplasms (Pancreatic Cancer)
3. Infection
4. B-Cell Lymphoma (Lymphoma, B Cell)
11/01/2006 - "Inhibitor of apoptosis proteins are differentially expressed in B-cell lymphomas. "
12/01/2012 - "Cytokine-induced apoptosis inhibitor (CIAP) is a novel antiapoptotic molecule, which is different to inhibitor of apoptosis protein or B-cell lymphoma 2. CIAP was originally identified as a molecule that conferred resistance to apoptosis induced by growth factor starvation. "
01/01/2014 - "This review highlights the recent advancements in the development of small-molecule inhibitors targeting three major classes of antiapoptotic proteins: antiapoptotic B cell lymphoma 2 (BCL-2) proteins, inhibitor of apoptosis proteins (IAPs), and murine double-minute 2 (MDM2). "
10/01/2007 - "With respect to SAHA, OSU-HDAC42 exhibited greater apoptogenic potency, which was associated with reduced levels of the apoptotic regulators phosphorylated Akt B-cell lymphoma-xL, survivin, cellular inhibitor of apoptosis protein 1, and cellular inhibitor of apoptosis protein 2. The in vivo efficacy of OSU-HDAC42 versus SAHA was assessed in orthotopic and subcutaneous xenograft tumor models in athymic nude mice. "
01/01/2013 - "CDDO-Me inhibited the expression of prosurvival phospho-AKT (p-AKT), phospho-mammalian target of rapamycin (p-mTOR) and nuclear factor-kappa B (NF-κB) (p65) signaling molecules and NF-κB-regulated antiapoptotic B-cell lymphoma-2 (BCL-2), B-cell lymphoma-extra large (BCL-xL), cellular inhibitor of apoptosis protein 1(c-IAP1) and survivin, but pre-treatment with NAC blocked the down-modulation of these signaling and antiapoptotic proteins by CDDO-Me. "
5. Wounds and Injuries (Trauma)

Related Drugs and Biologics

1. X-Linked Inhibitor of Apoptosis Protein
2. gemcitabine
3. Caspase 3 (Caspase-3)
4. Proteins (Proteins, Gene)
5. NF-kappa B (NF-kB)
6. Protons (Proton)
7. Messenger RNA (mRNA)
8. Staphylococcal Protein A (A, Protein)
9. Protein Kinases (Protein Kinase)
10. Phosphotransferases (Kinase)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Hepatectomy
3. Drug Therapy (Chemotherapy)
4. Radiotherapy
5. Immunotherapy