|1.||Asoh, Sadamitsu: 2 articles (01/2012 - 10/2008)|
|2.||Ohta, Shigeo: 2 articles (01/2012 - 10/2008)|
|3.||Kim, So-Young: 2 articles (06/2009 - 01/2008)|
|4.||Seo, Miran: 2 articles (06/2009 - 01/2008)|
|5.||Juhnn, Yong-Sung: 2 articles (06/2009 - 01/2008)|
|6.||Oh, Jung-Min: 2 articles (06/2009 - 01/2008)|
|7.||Doshi, Jignesh M: 2 articles (02/2008 - 12/2006)|
|8.||Tian, Defeng: 2 articles (02/2008 - 12/2006)|
|9.||Xing, Chengguo: 2 articles (02/2008 - 12/2006)|
|10.||Zhang, Yun-han: 2 articles (03/2006 - 07/2005)|
06/01/2015 - "The Bcl-xl protein is a potential drug target for cancer, and it has a relatively flat and flexible binding pocket. "
08/01/2013 - "Its mechanism may be related to inducing the apoptosis in tumor cells by down-regulating the expression of Bcl-xL protein."
12/01/2012 - "Bcl-xL protein belongs to BCL-2 family which has either pro- or anti-apoptotic activities owing to their importance in the regulation of apoptosis, tumor genesis and cellular responses to anti-cancer therapy. "
05/15/2012 - "Thus, Wip1 overexpression increases the sensitivity of p53-negative cancer cells to anticancer drugs by separately affecting Bax and Bcl-xL protein levels."
12/01/2011 - "Immunohistochemical staining showed that the Bcl-xL protein was mainly located in the cytoplasm of tumor cells. "
|2.||B-Cell Lymphoma (Lymphoma, B Cell)
03/04/2011 - "The anti-apoptotic B cell lymphoma-xl (Bcl-xl) protein inhibited the apoptotic effects of ISG54 as did the anti-apoptotic adenoviral E1B-19K protein. "
01/01/2005 - "Overexpression of Bcl-2/Bcl-X(L) protein has been observed in more than 80% of B-cell lymphomas. "
11/22/2011 - "CytNmnat1 protected neuronal cell bodies and processes against NMDA-induced excitotoxicity, whereas caspase inhibition or B-cell lymphoma-extra large (Bcl-XL) protein overexpression had no protective effects in cultured cortical neurons. "
04/01/2012 - "Particularly, B-cell lymphoma-X (BCL-XL) protein degradation was regulated by the JNK pathway in normal cells, but by p38 MAPK in MDS cells. "
06/11/2013 - "The aim of this study was to investigate the clinicopathological significance of Bcl-xL in upper urinary tract urothelial carcinoma (UTUC) and the therapeutic effect of targeting Bcl-xL protein in urothelial carcinoma (UC) cells. "
12/01/2002 - "To study the expression of early growth response gene-1 (Egr-1 gene) and Bcl-X/(L) protein and its relationship with the cell apoptosis in human esophageal carcinoma (EC) and precancerous lesions. "
01/01/2014 - "Additionally, immunohistochemical SP method and Western blot assays were employed to detect changes in Bcl-xL protein expression in different tongue carcinoma tissues. "
05/01/2005 - "Bcl-XL protein levels determine apoptotic index in pancreatic carcinoma."
12/01/2001 - "These results suggest that this decrease of Bcl-x protein might serve as an indicator of the advanced form of preneoplastic lesions, and that this decrease could also be associated with a potential to progress into carcinoma in both exogenous and endogenous hepatocarcinogenesis of rats."
|4.||Breast Neoplasms (Breast Cancer)
10/01/2005 - "Bcl-x(L) protein plays a role in breast cancer dormancy, promoting survival of cells in metastatic foci by counteracting the proapoptotic signals in the microenvironment. "
07/01/1997 - "Western blot analysis of eight primary breast cancers and five breast cancer cell lines indicated that BCL-xL was the predominant BCL-x protein expressed. "
09/01/2010 - "In this study, we demonstrated that enforced expression of Aven blocks UV-irradiation-, SN-38- or cisplatin-induced apoptosis upstream of mitochondria by stabilising Bcl-xL protein levels in breast cancer cells. "
07/01/1997 - "Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases."
04/01/2003 - "Overexpression of some oncogenes such as HER-2 (c-erbB-2, Neu), bcl-2/bcl-xL, protein kinase A (PKA), and transferrin receptor gene (TfR gene), etc significantly affect the prognosis of breast cancer. "
|5.||Myeloid Leukemia (Leukemia, Myelocytic)
08/01/1996 - "In the present studies, we determined the effects of enforced overexpression of the antiapoptosis Bcl-xL protein on taxol-mediated microtubule and cell cycle perturbations, as well as on taxol-induced apoptosis and associated Yama protease activity in human myeloid leukemia HL-60 cells. "
|1.||Caspase 3 (Caspase-3)
|3.||bcl-2 Homologous Antagonist-Killer Protein (bcl 2 Homologous Antagonist Killer Protein)
|5.||DNA (Deoxyribonucleic Acid)
|8.||Messenger RNA (mRNA)
|9.||Proteins (Proteins, Gene)
|10.||Cytochromes c (Cytochrome c)
|1.||Heterologous Transplantation (Xenotransplantation)