Voltage-Dependent Anion Channels

A family of voltage-gated eukaryotic porins that form aqueous channels. They play an essential role in mitochondrial CELL MEMBRANE PERMEABILITY, are often regulated by BCL-2 PROTO-ONCOGENE PROTEINS, and have been implicated in APOPTOSIS.

Also Known As:

Pore Forming Protein VDAC; VDAC Proteins; Voltage-Dependent, Anion-Selective Channels; Anion Channel, Voltage-Dependent; Anion Channels, Voltage-Dependent; Anion-Selective Channels Voltage-Dependent; Channel, Voltage-Dependent Anion; Channels Voltage-Dependent, Anion-Selective; Voltage Dependent Anion Channel; Voltage Dependent Anion Channels; Voltage Dependent, Anion Selective Channels; Voltage-Dependent Anion Channel

Networked: 128 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Porins: 352
        Voltage-Dependent Anion Channels: 128
        Voltage-Dependent Anion Channel 1: 79
        Voltage-Dependent Anion Channel 2: 8
        VDAC Deficiency: 1
        Arabidopsis VDAC3 protein
        Drosophila porin protein
        human VDAC3 protein
        mouse Vdac3 protein
        rat Vdac3 protein
        rat VDAC3v protein
        zebrafish Kcng4b protein
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Ion Channels: 6731
        Porins: 352
        Voltage-Dependent Anion Channels: 128
        Voltage-Dependent Anion Channel 1: 79
        Voltage-Dependent Anion Channel 2: 8
        VDAC Deficiency: 1
        Arabidopsis VDAC3 protein
        Drosophila porin protein
        human VDAC3 protein
        mouse Vdac3 protein
        rat Vdac3 protein
        rat VDAC3v protein
        zebrafish Kcng4b protein
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Porins: 352
        Voltage-Dependent Anion Channels: 128
        Voltage-Dependent Anion Channel 1: 79
        Voltage-Dependent Anion Channel 2: 8
        VDAC Deficiency: 1
        Arabidopsis VDAC3 protein
        Drosophila porin protein
        human VDAC3 protein
        mouse Vdac3 protein
        rat Vdac3 protein
        rat VDAC3v protein
        zebrafish Kcng4b protein

Experts

1.	Lemasters, John J: 4 articles (11/2022 - 09/2012)
2.	Shoshan-Barmatz, Varda: 4 articles (01/2018 - 05/2008)
3.	Gonzalez-Gronow, Mario: 4 articles (09/2014 - 11/2007)
4.	Pizzo, Salvatore V: 4 articles (09/2014 - 11/2007)
5.	Maldonado, Eduardo N: 3 articles (01/2018 - 09/2012)
6.	Li, Li: 2 articles (11/2022 - 01/2018)
7.	Sheng, Xiuzhen: 2 articles (07/2020 - 01/2019)
8.	Tang, Xiaoqian: 2 articles (07/2020 - 01/2019)
9.	Xing, Jing: 2 articles (07/2020 - 01/2019)
10.	Zhan, Wenbin: 2 articles (07/2020 - 01/2019)

Related Diseases

1.	Infections 01/01/2014 - "Voltage dependent anion channel is redistributed during Japanese encephalitis virus infection of insect cells." 10/25/2016 - "Involvement of voltage-dependent anion channel (VDAC) in dengue infection." 12/01/2011 - "A previous study showed that WSSV infection led to upregulation of the voltage-dependent anion channel (VDAC), which is known to be involved in both the Warburg effect and MMP. " 02/01/2018 - "The Voltage-Dependent Anion Channel (VDAC) of Pacific Oysters Crassostrea gigas Is Upaccumulated During Infection by the Ostreid Herpesvirus-1 (OsHV-1): an Indicator of the Warburg Effect." 04/01/2013 - "The basic sequence of events is as follows: first, when a WSSV infection occurs, cellular sensors detect the invading virus, and activate signaling pathways that lead to (1) the expression of pro-apoptosis proteins, including PmCasp (an effecter caspase), MjCaspase (an initiator caspase) and voltage-dependent anion channel (VDAC); and (2) mitochondrial changes, including the induction of mitochondrial membrane permeabilization and increased oxidative stress. "
2.	Hepatocellular Carcinoma (Hepatoma) 11/01/2020 - "System biology analysis reveals the role of voltage-dependent anion channel in mitochondrial dysfunction during non-alcoholic fatty liver disease progression into hepatocellular carcinoma." 03/11/1986 - "Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC." 04/26/2013 - "Respiratory substrates and adenine nucleotides cross the mitochondrial outer membrane through the voltage-dependent anion channel (VDAC), comprising three isoforms--VDAC1, 2, and 3. We characterized the role of individual isoforms in mitochondrial metabolism by HepG2 human hepatoma cells using siRNA. " 11/01/2021 - ": 3-MA: 3-methyladenine; 5-hmC: 5-hydroxymethylcytosine; ACTB: actin beta; ATG5: autophagy related 5; ATM: ATM serine/threonine kinase; DFFB/CAD: DNA fragmentation factor subunit beta; cmtDNA: cytosolic mitochondrial DNA; ConA: concanamycin A; CQ: chloroquine; CsA: cyclosporin A; Dox: doxycycline; DSB: double-strand break; ENDOG: endonuclease G; GFP: green fluorescent protein; Gy: gray; H2AX: H2A.X variant histone; HBV: hepatitis B virus; HBx: hepatitis B virus X protein; HCC: hepatocellular carcinoma; I-PpoI: intron-encoded endonuclease; IR: ionizing radiation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MOMP: mitochondrial outer membrane permeability; mPTP: mitochondrial permeability transition pore; mtDNA: mitochondrial DNA; nDNA: nuclear DNA; 4-OHT: 4-hydroxytamoxifen; rDNA: ribosomal DNA; ROS: reactive oxygen species; SQSTM1/p62: sequestosome 1; TET: tet methylcytosine dioxygenase; TFAM: transcription factor A, mitochondrial; TOMM20: translocase of outer mitochondrial membrane 20; VDAC: voltage dependent anion channel."
3.	Hypoxia (Hypoxemia) 06/09/2006 - "Co-immunoprecipitation studies indicate that SUS interacts with the voltage-dependent anion channel in an isoform-specific and anoxia-enhanced manner and may be involved in the regulation of solute fluxes into and out of mitochondria. " 08/01/2004 - "Channel activity induced by cleaved BCL-xL or by hypoxia is attenuated by NADH, an inhibitor of the voltage-dependent anion channel (VDAC) of mitochondrial outer membranes. " 07/01/2014 - "Mitochondrial hexokinase (HK) and creatine kinase (CK) known to form complexes with a voltage dependent anion channel (VDAC) have been reported to increase cell death resistance under hypoxia/anoxia. " 01/01/2007 - "This inference is based on the following observations: (a) tissue-specific, isoform-dependent and metabolically-regulated association of SUS with mitochondria and (b) isoform-specific and anoxia-responsive interaction of SUS with the voltage-dependent anion channel (VDAC), the major outer mitochondrial membrane protein. "
4.	Endometrial Neoplasms (Endometrial Cancer) 08/01/2020 - "Expression of voltage-dependent anion channels in endometrial cancer and its potential prognostic significance." 08/01/2020 - "Our results suggest that increased expression of voltage-dependent anion channels correlates with tumor progression and may serve as a potential prognostic biomarker in endometrial cancer." 08/01/2020 - "The aim of this study was to investigate the mRNA and protein expression levels of VDAC1, VDAC2, and VDAC3 in relation to clinicopathological characteristics of endometrial cancer as well as the prognostic significance of voltage-dependent anion channels expression for overall survival. "
5.	Hypothermia 01/01/2020 - "In this in vitro study, a model of oxygen-glucose deprivation, followed by recovery (OGD/R), was used to investigate whether hypothermia exerts anti-inflammatory and anti-apoptosis properties via enhanced ubiquitination and down-regulation of voltage-dependent anion channel 3 (VDAC3) expression. "

Related Drugs and Biologics

1.	Hexokinase
2.	Proteins (Proteins, Gene)
3.	Protein Isoforms (Isoforms)
4.	Glucose (Dextrose)
5.	Matrix Metalloproteinases (MMPs)
6.	Messenger RNA (mRNA)
7.	Oxygen (Dioxygen)
8.	Dicyclohexylcarbodiimide (DCCD)
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Liver Transplantation
2.	Radiotherapy
3.	Induced Heart Arrest (Cardioplegia)