GATA4 Transcription Factor

A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.

Also Known As:

GATA-4 Transcription Factor; Transcription Factor GATA-4; Transcription Factor GATA4; Factor GATA-4, Transcription; Factor GATA4, Transcription; GATA 4 Transcription Factor; GATA-4, Transcription Factor; GATA4, Transcription Factor; Transcription Factor GATA 4; Transcription Factor, GATA-4; Transcription Factor, GATA4

Networked: 60 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - GATA Transcription Factors: 127
      - GATA4 Transcription Factor: 60
        human GATA4 protein
        mouse Gata4 protein
        rat Gata4 protein
        Xenopus GATA4 protein
  - DNA-Binding Proteins: 2009
    - GATA Transcription Factors: 127
      - GATA4 Transcription Factor: 60
        human GATA4 protein
        mouse Gata4 protein
        rat Gata4 protein
        Xenopus GATA4 protein

Experts

1.	Heikinheimo, Markku: 6 articles (07/2018 - 10/2004)
2.	Wilson, David B: 6 articles (07/2018 - 10/2004)
3.	Kyrönlahti, Antti: 4 articles (07/2018 - 09/2010)
4.	Pu, William T: 4 articles (03/2012 - 04/2006)
5.	Hasegawa, Koji: 3 articles (01/2022 - 03/2002)
6.	Morimoto, Tatsuya: 3 articles (01/2022 - 03/2002)
7.	Soini, Tea: 3 articles (07/2018 - 01/2012)
8.	Andersson, Leif C: 3 articles (03/2017 - 07/2009)
9.	Bisping, Egbert: 3 articles (03/2012 - 04/2006)
10.	Katanasaka, Yasufumi: 2 articles (01/2022 - 12/2016)

Related Diseases

1.	Cardiomegaly (Heart Hypertrophy) 02/27/2004 - "Our recent experiments demonstrate that the GATA-4 transcription factor not only mediates cardiac hypertrophy, but also regulates apoptosis and survival of adult cardiac muscle cells. " 06/27/2003 - "Accumulating evidence suggests an important role for the zinc finger transcription factor GATA-4 in hypertrophic agonist-induced cardiac hypertrophy. " 10/05/2001 - "Transcription factor GATA-4 plays critical roles in controlling heart development and cardiac hypertrophy. " 01/01/2022 - "The activation of the GATA-binding factor 4 (GATA4) transcription factor induces cardiac hypertrophy and heart failure. " 02/15/2002 - "Our previous study demonstrated that endothelin-1 induced a phosphorylation of GATA-4 transcription factor, which plays important roles in cardiac hypertrophy and failure. "
2.	Ischemia 05/29/2009 - "The present study was to investigate whether transcription factor GATA-4 could be involved in EPO-induced cardioprotection when it was administered after ischemia, immediately before reperfusion. "
3.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2022 - "Further studies revealed that the transcription factor GATA4 binding to Gαi3 promoter region was significantly enhanced in cervical cancer tissues and cells. "
4.	Hypertrophy 11/26/2019 - "Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy." 01/01/2009 - "Relation of Cardiotrophin-1 (CT-1) and cardiac transcription factor GATA4 expression in rat's cardiac myocytes hypertrophy and apoptosis." 09/26/2006 - "In cultured cardiomyocytes, the transcription factor Gata4 is required for agonist-induced hypertrophy. " 12/02/2016 - "Regulation of Cardiac Transcription Factor GATA4 by Post-Translational Modification in Cardiomyocyte Hypertrophy and Heart Failure." 08/01/2015 - "TIEG1 Inhibits Angiotensin II-induced Cardiomyocyte Hypertrophy by Inhibiting Transcription Factor GATA4."
5.	Neoplasms (Cancer) 01/01/2012 - "Transcription factor GATA-4 is abundantly expressed in childhood but not in adult liver tumors." 09/01/2010 - "Our results demonstrate that the TRAIL pathway is functional in GCT cells, and suggest that transcription factor GATA4 may function as a survival factor in this ovarian malignancy." 07/01/2004 - "Recently we showed that gonadectomized DBA/2J mice develop adrenocortical tumors that express transcription factor GATA-4. " 07/01/2004 - "Transcription factor GATA-4 is a marker of anaplasia in adrenocortical neoplasms of the domestic ferret (Mustela putorius furo)." 07/01/2015 - "Immunostaining and Western blot analyses confirmed FOXO1 and phosphatase and tensin homolog (PTEN) depletion, maintenance of globin transcription factor (GATA) 4 and nuclear localization of FOXL2 and phosphorylated small mothers against decapentaplegic (SMAD) 2/3 in the tumor cells, recapitulating results we observed in human adult GCTs. "

Related Drugs and Biologics

1.	Endothelin-1 (Endothelin 1)
2.	Proteins (Proteins, Gene)
3.	Atrial Natriuretic Factor (ANF)
4.	Doxorubicin (Adriamycin)
5.	Tumor Viral Antigens (Large T Antigen)
6.	Connective Tissue Growth Factor
7.	Transforming Growth Factor beta1 (TGF beta 1)
8.	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)
9.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
10.	Mitogen-Activated Protein Kinase 3

Related Therapies and Procedures

1.	Electroacupuncture
2.	Castration
3.	Analgesia