GATA2 Transcription Factor

An essential GATA transcription factor that is expressed primarily in HEMATOPOIETIC STEM CELLS.

Also Known As:

GATA-Binding Protein 2; NFE1B Erythroid Transcription Factor; Nuclear Factor-Erythroid 1B; Transcription Factor GATA-2; GATA Binding Protein 2; GATA-2, Transcription Factor; Nuclear Factor Erythroid 1B; Transcription Factor GATA 2; Transcription Factor, GATA2

Networked: 62 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - GATA Transcription Factors: 127
      - GATA2 Transcription Factor: 62
        human GATA2 protein
        mouse Gata2 protein
        rat Gata2 protein
        Xenopus GATA2 protein
        zebrafish Gata2a protein
        zebrafish Gata2b protein
    - Erythroid-Specific DNA-Binding Factors
      - GATA2 Transcription Factor: 62
        human GATA2 protein
        mouse Gata2 protein
        rat Gata2 protein
        Xenopus GATA2 protein
        zebrafish Gata2a protein
        zebrafish Gata2b protein
  - DNA-Binding Proteins: 2009
    - GATA Transcription Factors: 127
      - GATA2 Transcription Factor: 62
        human GATA2 protein
        mouse Gata2 protein
        rat Gata2 protein
        Xenopus GATA2 protein
        zebrafish Gata2a protein
        zebrafish Gata2b protein
    - Erythroid-Specific DNA-Binding Factors
      - GATA2 Transcription Factor: 62
        human GATA2 protein
        mouse Gata2 protein
        rat Gata2 protein
        Xenopus GATA2 protein
        zebrafish Gata2a protein
        zebrafish Gata2b protein

Experts

1.	Holland, Steven M: 6 articles (01/2022 - 04/2013)
2.	Hsu, Amy P: 5 articles (01/2022 - 04/2013)
3.	Calvo, Katherine R: 4 articles (01/2022 - 02/2014)
4.	Hickstein, Dennis D: 4 articles (01/2022 - 02/2014)
5.	Wang, Weixin: 3 articles (01/2022 - 11/2020)
6.	Bresnick, Emery H: 3 articles (11/2020 - 09/2017)
7.	Johnson, Kirby D: 3 articles (11/2020 - 09/2017)
8.	Chen, Lei: 3 articles (09/2016 - 06/2013)
9.	Jiang, Beihai: 3 articles (09/2016 - 06/2013)
10.	Su, Xiangqian: 3 articles (09/2016 - 06/2013)

Related Diseases

1.	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/01/2016 - "The aim of our study was to analyze bone marrow and peripheral blood samples of children with myelodysplastic syndrome or aplastic anemia to define prevalence of the GATA2 mutation and to assess whether mutations in GATA-2 transcription factor exhibit specific immunophenotypic features. " 01/01/2023 - "Mono-allelic germline disruptions of the transcription factor GATA2 result in a propensity for developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), affecting more than 85% of carriers. " 10/01/2020 - "Deficiency of the transcription factor GATA2 is a highly penetrant genetic disorder predisposing to myelodysplastic syndromes (MDS) and immunodeficiency. " 01/01/2019 - "GATA-binding protein 2 (GATA2) mutations cause GATA-2 deficiency syndrome involving immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia. " 03/17/2016 - "The Gata2 transcription factor is a pivotal regulator of hematopoietic cell development and maintenance, highlighted by the fact that Gata2 haploinsufficiency has been identified as the cause of some familial cases of acute myelogenous leukemia/myelodysplastic syndrome and in MonoMac syndrome. "
2.	Hematologic Neoplasms (Hematological Malignancy) 08/01/2009 - "To further ascertain the truth of transcription factor GATA-2 in hematological malignancies, we expanded our study to GATA-2 full length by directly sequencing and applied MassARRAY assay into GATA-2 L359 V mutation analysis. " 12/01/2021 - "GATA binding protein 2 (GATA2) gene, involved in progression of hematologic malignancies and various solid tumors, is a susceptibility gene for inherited acute myeloid leukemia (AML). " 01/01/2015 - "GATA binding protein 2 (GATA2) is a transcription factor that has essential roles in hematologic malignancies and progression of various solid tumors. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/15/2012 - "In a recent issue of Cell, Kumar and colleagues uncovered a synthetic lethal interaction between oncogenic KRAS and the transcription factor GATA2 in non-small cell lung carcinoma. " 08/04/2014 - "In this study, we exploited a therapeutic strategy based on the interaction between GATA binding protein 2 (GATA2) downregulation and the KRAS mutation status by delivering small interfering RNA targeting GATA2 (siGATA2) with cationic lipid-assisted polymeric nanoparticles for treatment of non-small-cell lung carcinoma (NSCLC) harboring oncogenic KRAS mutations. " 12/01/2022 - ": ADPN: adiponectin; aP2: adipocyte protein 2 or fatty acid binding protein 4 (FABP4); BCA: bicinchoninic acid assay; BFA: bafilomycin A1; BMI: body mass index; C/EBP: CCAAT/enhancer binding protein; CEBPA: CCAAT/enhancer-binding protein-alpha; C-Exo: cancer cell-derived exosomes; CNTL: control; CREB: cAMP-response element binding protein; CytoD: cytochalasin D; ECL: chemiluminescence; GATA2: GATA Binding Protein 2; HFD: high fat diet; HSL: hormone-sensitive lipase; IGFBP4: insulin like growth factor binding protein 4; IRS-1: insulin receptor substrate-1; ISO: isoproterenol hydrochloride; KD: knockdown; KO: knock out; LC3: microtubule-associated protein 1A/1B-light chain 3; LMF: lipid mobilizing factor; LPL: lipoprotein lipase; MMP15: matrix metallopeptidase 15; Mir-Inh-C-Exo: cancer cell-derived exosomes with miR-425-3p inhibition; mTOR: mammalian target of rapamycin; Mut: mutant; N-Exo: normal cell-derived exosomes; NSCLC: non-small cell lung cancer; PBS, phosphate buffered saline; PGC-1: peroxisome proliferator-activated receptor-gamma coactivator-1; PDEs: phosphodiesterases; PKI: PKA inhibitor; PKA: cAMP-dependent protein kinase; PLIN1: Perilipin 1; PTHRP: parathyroid hormone-related protein; PVDF: polyvinylidene difluoride; shRNA: short hairpin RNA; UCP1: uncoupling protein 1; WT: wild type."
4.	Aplastic Anemia (Anemia, Hypoplastic) 04/01/2001 - "Decreased expression of transcription factor GATA-2 in haematopoietic stem cells in patients with aplastic anaemia." 01/01/2016 - "The aim of our study was to analyze bone marrow and peripheral blood samples of children with myelodysplastic syndrome or aplastic anemia to define prevalence of the GATA2 mutation and to assess whether mutations in GATA-2 transcription factor exhibit specific immunophenotypic features. "
5.	Adenomyosis 11/14/2023 - "To study the effect of adenomyosis on the localized expression of the GATA binding protein 2 and 6 (GATA2 and GATA6) zinc-finger transcription factors that are involved in proliferation of hematopoietic and endocrine cell lineages, and cell differentiation and organogenesis, potentially leading to impaired endometrial implantation. "

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Small Interfering RNA (siRNA)
3.	Aquaporin 4
4.	Peroxisome Proliferator-Activated Receptors (PPAR)
5.	Lipids
6.	Proteins (Proteins, Gene)
7.	GATA2 Transcription Factor
8.	CCAAT-Enhancer-Binding Protein-alpha
9.	Messenger RNA (mRNA)
10.	Carrier Proteins (Binding Protein)

Related Therapies and Procedures

1.	Stem Cell Transplantation