|1.||Holland, Steven M: 3 articles (02/2014 - 04/2013)|
|2.||Hsu, Amy P: 3 articles (02/2014 - 04/2013)|
|3.||Su, Xiangqian: 2 articles (01/2015 - 06/2013)|
|4.||Chen, Lei: 2 articles (01/2015 - 06/2013)|
|5.||Wang, Zaozao: 2 articles (01/2015 - 06/2013)|
|6.||Jiang, Beihai: 2 articles (01/2015 - 06/2013)|
|7.||Zerbe, Christa S: 2 articles (02/2014 - 04/2013)|
|8.||Uzel, Gulbu: 2 articles (02/2014 - 04/2013)|
|9.||Mace, Emily M: 2 articles (02/2014 - 04/2013)|
|10.||Cuellar-Rodriguez, Jennifer: 2 articles (02/2014 - 02/2014)|
|1.||Hematologic Neoplasms (Hematological Malignancy)
08/01/2009 - "To further ascertain the truth of transcription factor GATA-2 in hematological malignancies, we expanded our study to GATA-2 full length by directly sequencing and applied MassARRAY assay into GATA-2 L359 V mutation analysis. "
01/01/2015 - "GATA binding protein 2 (GATA2) is a transcription factor that has essential roles in hematologic malignancies and progression of various solid tumors. "
|2.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/15/2012 - "In a recent issue of Cell, Kumar and colleagues uncovered a synthetic lethal interaction between oncogenic KRAS and the transcription factor GATA2 in non-small cell lung carcinoma. "
08/04/2014 - "In this study, we exploited a therapeutic strategy based on the interaction between GATA binding protein 2 (GATA2) downregulation and the KRAS mutation status by delivering small interfering RNA targeting GATA2 (siGATA2) with cationic lipid-assisted polymeric nanoparticles for treatment of non-small-cell lung carcinoma (NSCLC) harboring oncogenic KRAS mutations. "
|3.||Parkinson Disease (Parkinson's Disease)
05/01/2010 - "Association study of GATA-2 transcription factor gene (GATA2) polymorphism and Parkinson's disease."
05/01/2010 - "It was shown that high levels of alpha-synuclein in substantia nigra are essential in pathogenesis of Parkinson disease (PD), and SNCA expression in neurons is controlled by GATA-2 transcription factor, which plays also crucial role in central nervous system development, and erythroid cells differentiation. "
|4.||Coronary Artery Disease (Coronary Atherosclerosis)
01/01/2010 - "The transcription factor GATA-2 does not associate with angiographic coronary artery disease in the Ottawa Heart Genomics and Cleveland Clinic GeneBank Studies."
01/01/2010 - "The transcription factor GATA2 was reported to associate with coronary artery disease (CAD) in the family-based Genecard sample (Connelly et al. in PLoS Genet 2:e139, 2006). "
12/01/2013 - "Patients with GATA binding protein 2 deficiency are susceptible to both mycobacterial and viral infections, and display NKDs and a lack of monocytes. "
04/01/2013 - "However, this latency-associated expression of UL144 occurs only in certain isolates of HCMV and depends on the presence of functional GATA-2 transcription factor binding sites in the UL144 promoter, in contrast to the viral latency-associated gene LUNA, which we also show is regulated by GATA-2 but expressed uniformly during latent infection independent of the virus isolate. "
01/01/2015 - "GATA-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. "
02/06/2014 - "Haploinsufficiency of the hematopoietic transcription factor GATA2 underlies monocytopenia and mycobacterial infections; dendritic cell, monocyte, B, and natural killer (NK) lymphoid deficiency; familial myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML); and Emberger syndrome (primary lymphedema with MDS). "
|1.||Small Interfering RNA (siRNA)
|2.||GATA2 Transcription Factor
|3.||Transcription Factors (Transcription Factor)
|4.||Messenger RNA (mRNA)
|5.||Carrier Proteins (Binding Protein)
|7.||COUP Transcription Factor II
|8.||YY1 Transcription Factor
|9.||Core Binding Factor Alpha 2 Subunit
|10.||Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)