GATA1 Transcription Factor

A GATA transcription factor that is specifically expressed in hematopoietic lineages and plays an important role in the CELL DIFFERENTIATION of ERYTHROID CELLS and MEGAKARYOCYTES.

Also Known As:

Eryf1 Erythroid-Specific Transcription Factor; Erythroid Transcription Factor 1; Globin Transcription Factor 1; NF-E1 Erythroid-Specific Transcription Factor; Nuclear Factor-Erythroid 1; Transcription Factor GATA1; Transcription Factor NFE-1; Eryf1 Erythroid Specific Transcription Factor; Factor GATA1, Transcription; GATA1, Transcription Factor; NF E1 Erythroid Specific Transcription Factor; NFE-1, Transcription Factor; Nuclear Factor Erythroid 1; Transcription Factor, GATA1

Networked: 44 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Vyas, Paresh: 6 articles (01/2021 - 04/2004)
2.	Roberts, Irene: 4 articles (01/2021 - 04/2004)
3.	Orkin, Stuart H: 3 articles (01/2022 - 02/2006)
4.	Martelli, Fabrizio: 2 articles (01/2021 - 01/2020)
5.	Migliaccio, Anna Rita: 2 articles (01/2021 - 01/2020)
6.	Verachi, Paola: 2 articles (01/2021 - 01/2020)
7.	Zingariello, Maria: 2 articles (01/2021 - 01/2020)
8.	Wei, Bo: 2 articles (04/2018 - 03/2016)
9.	Ge, Yubin: 2 articles (04/2010 - 02/2005)
10.	Thomas, Angela: 2 articles (06/2005 - 04/2004)

Related Diseases

1.	Osteoarthritis 09/01/2018 - "In the present study, it was discovered that expression of the key erythroid factor, globin transcription factor 1 (GATA1), is significantly greater in human RA synovial tissues than in osteoarthritis (OA) tissues. "
2.	Down Syndrome (Down's Syndrome) 09/01/2007 - "The cytogenetic and molecular studies within from the blood blast cells identified a trisomy 21 and a partial deletion in exon 2 of the transcription factor GATA1. " 05/01/2014 - "Trisomy 21 alters fetal liver hematopoiesis and, in combination with somatic globin transcription factor 1 (GATA1) mutations, leads to development of transient myeloproliferative disease in newborns. " 12/01/2006 - "In addition to trisomy 21, fetal haemopoietic progenitors acquire N-terminal truncating mutations in the key megakaryocyte-erythroid transcription factor GATA1. " 06/01/2003 - "Recently mutations of the gene encoding the hematopoietic transcription factor GATA1 were shown to be specific for AMKL of Down syndrome. " 02/02/2005 - "Somatic mutations in the GATA1 transcription factor have been detected exclusively and almost uniformly in Down syndrome AMkL patients, suggesting a potential linkage to the chemotherapy sensitivity of Down syndrome megakaryoblasts. "
3.	Anemia 01/01/2023 - "Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1. " 01/01/2022 - "Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1." 01/01/2022 - "Germline defects in the transcription factor GATA1 are known to cause dyserythropoiesis with(out) anemia and variable abnormalities in platelet count and function. " 01/15/2002 - "Different substitutions at residue D218 of the X-linked transcription factor GATA1 lead to altered clinical severity of macrothrombocytopenia and anemia and are associated with variable skewed X inactivation." 10/01/2016 - "Results from small interfering RNA and gain-of-function (gfp-globin transcription factor 1 retrovirus) studies indicate that targeted interventions to restore V-maf musculoaponeurotic fibrosarcoma oncogene homolog B/globin transcription factor 1 balance can mitigate both immune imbalance and anemia of critical illness."
4.	Leukemia 11/01/2003 - "To determine whether mutations in the hematopoietic transcription factor GATA1 are associated with leukemia, we assayed for alterations in the GATA1 gene in bone marrow samples from patients with various subtypes of acute leukemia. " 09/01/2007 - "Recent studies of the megakaryoblastic leukemias of Down syndrome have uncovered a developmental leukemogenic mechanism characterized by a unique pre-natal collaboration between overexpressed genes from chromosome 21 and an acquired mutation in the transcription factor GATA1. " 08/01/2003 - "Recently, mutations of the GATA1 transcription factor have been identified in the megakaryoblastic leukemia of Down syndrome. " 04/01/2012 - "Mutations of the hematopoietic transcription factor GATA1 (GATA1s) are pathognomonic in newborn with transient leukemia and children with Down syndrome and myeloid leukemia (ML-DS). "
5.	Critical Illness (Critically Ill) 10/01/2016 - "Results from small interfering RNA and gain-of-function (gfp-globin transcription factor 1 retrovirus) studies indicate that targeted interventions to restore V-maf musculoaponeurotic fibrosarcoma oncogene homolog B/globin transcription factor 1 balance can mitigate both immune imbalance and anemia of critical illness."

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Proteins (Proteins, Gene)
3.	Focal Adhesion Protein-Tyrosine Kinases
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
5.	Cytokine Receptors (Cytokine Receptor)
6.	Transcription Factors (Transcription Factor)
7.	Messenger RNA (mRNA)
8.	Porphyrins
9.	Iron
10.	Interleukin-3 (Interleukin 3)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)