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Basic-Leucine Zipper Transcription Factors

A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.
Also Known As:
GBF bZIP Transcription Factors; bZIP Proteins; bZIP Transcription Factors; Basic Leucine Zipper Transcription Factors; Transcription Factors, bZIP; bZIP G Box Binding Factors; bZIP G-Box Binding Factors
Networked: 21 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Schibler, Ueli: 2 articles (10/2010 - 06/2004)
2. Gachon, Frédéric: 2 articles (10/2010 - 06/2004)
3. Halterman, Marc W: 2 articles (07/2010 - 06/2008)
4. Federoff, Howard J: 2 articles (07/2010 - 06/2008)
5. Schor, Nina F: 2 articles (07/2010 - 06/2008)
6. Hai, Tsonwin: 2 articles (01/2010 - 02/2004)
7. Alves, Murilo S: 1 article (11/2015)
8. Aoyagi, Luciano N: 1 article (11/2015)
9. Poddanosqui, Adriana M P: 1 article (11/2015)
10. Barros, Everaldo G: 1 article (11/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Leukemia
10/01/2010 - "We have previously shown that the rhythmic transcription of output genes is, in part, regulated by the clock-controlled PAR bZip transcription factors DBP (albumin D-site binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor). "
06/01/1996 - "To understand the mechanisms by which E2A-HLF induces leukemia and the crucial functions contributed by each constituent of the chimera, it is essential to define the normal transcriptional regulatory properties of HLF and related bZIP proteins. "
06/01/2009 - "PAR bZIP (cells knockout for PAR bZIP transcription factors) proteins, thyrotroph embryonic factor (TEF), albumin D-site-binding protein (DBP), and hepatic leukemia factor (HLF), are a family of transcription factors that have been shown to contribute to the expression of genes involved in detoxification and drug metabolism. "
12/15/2006 - "Proline- and acid-rich (PAR) basic region leucine zipper (bZIP) proteins thyrotroph embryonic factor (TEF), D-site-binding protein (DBP), and hepatic leukemia factor have been involved in neurotransmitter homeostasis and amino acid metabolism. "
03/01/1997 - "The E2A-HLF fusion gene, created by the t(17;19)(q22;p13) chromosomal translocation in pro-B lymphocytes, encodes an oncogenic protein in which the E2A trans-activation domain is linked to the DNA-binding and protein dimerization domain of hepatic leukemia factor (HLF), a member of the proline- and acidic amino acid-rich (PAR) subfamily of bZIP transcription factors. "
3. Anoxia (Hypoxia)
4. Infection
5. Cataract (Cataracts)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. CCAAT-Enhancer-Binding Proteins
3. DNA (Deoxyribonucleic Acid)
4. CCAAT-Enhancer-Binding Protein-beta
5. Transcription Factor AP-1 (Transcription Factor AP 1)
6. Transcription Factors (Transcription Factor)
7. Proline (L-Proline)
8. Activating Transcription Factor 3
9. Acidic Amino Acids
10. Neurotransmitter Agents (Neurotransmitter)