HSP47 Heat-Shock Proteins (Heat Shock Protein 47)

01/01/2014 - "In this study, we found that the expression of heat shock protein 47 was significantly increased in patients with Schistosoma-induced fibrosis, as well as in rodent models. "
12/01/2023 - "Heat shock protein 47 (HSP47) plays a key role in the development of intestinal fibrosis. "
11/27/2017 - "Heat shock protein 47 effects on hepatic stellate cell-associated receptors in hepatic fibrosis of Schistosoma japonicum-infected mice."
01/01/2014 - "Involvement of heat shock protein 47 in Schistosoma japonicum-induced hepatic fibrosis in mice."
09/23/2011 - "Furthermore, regular exercise decreased the expression of heat shock protein 47, a marker of hepatic fibrosis, in the liver. "

08/01/2005 - "Heat shock protein 47 may play an important role in promoting the formation of pathological scar tissue."
11/01/2000 - "Heat shock protein 47 in renal scarring."
01/01/2023 - "To evaluate the effectiveness of knock-down of heat shock protein 47 (HSP47) on conjunctival bleb scarring in a rat model and its possible mechanism. "
01/01/2023 - "Effectiveness of conjunctival bleb scarring by knock-down of heat shock protein 47 in rat model."
01/01/2005 - "To study the expression of heat shock protein 47 (HSP47) and its correlation to collagen deposition in pathological scar tissues. "

11/27/2017 - "The study aimed to explore the regulation of heat shock protein 47 (HSP47) on expressions of receptors associated with hepatic stellate cell (HSC) in liver fibrosis mouse models induced by Schistosoma japonicum (S. "
02/01/2023 - "Coimmunoprecipitation, immunofluorescence staining, western blotting and qRT-PCR were conducted to identify the regulatory effects of BGN on heat shock protein 47 (HSP47) expression and liver fibrosis. "
01/01/2014 - "japonicum-induced liver fibrosis and attempted to determine whether inhibition of heat shock protein 47 could have beneficial effects on fibrosis in vitro and in vivo. "
01/01/2023 - "In a preclinical model of liver fibrosis, AA-T3A-C12 enables ~65% silencing of heat shock protein 47, a therapeutic target primarily expressed by activated fibroblasts, which is 2-fold more potent than MC3, leading to significantly reduced collagen deposition and liver fibrosis. "
01/01/2018 - "Heat shock protein 47 as indispensible participant in liver fibrosis: Possible protective effect of lactoferrin."

01/01/2023 - "The dramatic increase in the stromal levels of SERPINH1/heat shock protein 47, that was discovered using our ECM proteomic pipeline, was validated by immunohistochemistry (IHC) of "Tumor" and "Matched Normal" tissues, obtained from an independent cohort of LSCC patients. "
01/01/2022 - "Meanwhile, various researchers have reported that heat shock protein 47 (HSP47) plays a vital regulatory role in cancer. "
12/01/2020 - "Accumulating evidence suggests that overexpression of heat shock protein 47 (HSP47) increases cancer progression, and that HSP47 level in the tumor-associated stroma may serve as a diagnostic marker in various cancers. "
01/01/2020 - "Heat Shock Protein 47 Maintains Cancer Cell Growth by Inhibiting the Unfolded Protein Response Transducer IRE1α."
05/01/2014 - "Heat shock protein 47 regulated by miR-29a to enhance glioma tumor growth and invasion."

01/01/2021 - "Screening of Inhibitors Targeting Heat Shock Protein 47 Involved in the Development of Idiopathic Pulmonary Fibrosis."
09/01/2013 - "Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis."
12/01/2000 - "In this study, we examined the expression of heat shock protein 47 and type I procollagen in 12 patients with usual interstitial pneumonia by immunohistochemistry on sequential sections. "
12/01/2000 - "Heat shock protein 47 was localized predominantly in alpha-smooth muscle actin-positive myofibroblasts and surfactant protein-A-positive type II pneumocytes in active fibrotic areas of usual interstitial pneumonia. "
12/01/2000 - "Our results suggest that myofibroblasts and type II pneumocytes play an important role in the progression of fibrosis through the induction of heat shock protein 47, which regulates the synthesis/assembly of type I procollagen in usual interstitial pneumonia. "