|1.||Vance, Dennis E: 11 articles (09/2015 - 01/2003)|
|2.||Jacobs, René L: 6 articles (09/2015 - 09/2009)|
|3.||Gao, Xia: 3 articles (09/2015 - 02/2015)|
|4.||van der Veen, Jelske N: 3 articles (09/2015 - 02/2015)|
|5.||Vance, Jean E: 3 articles (09/2015 - 04/2009)|
|6.||Zhao, Yang: 3 articles (07/2010 - 02/2003)|
|7.||Lieber, C S: 3 articles (11/2001 - 01/2000)|
|8.||Koonen, Debby P Y: 2 articles (04/2015 - 07/2010)|
|9.||Gomez-Muñoz, Antonio: 2 articles (04/2015 - 02/2015)|
|10.||Lingrell, Susanne: 2 articles (04/2015 - 07/2010)|
06/01/1994 - "1. Alcohol consumption diminishes phosphatidylethanolamine N-methyltransferase activity prior to the development of cirrhosis and decreases the hepatic content of its product, namely phosphatidylcholine, a key component of cell membranes. "
01/01/1994 - "Elucidation of the biochemical effects of ethanol are now resulting in improved therapy: in baboons, S-adenosyl-L-methionine attenuates the ethanol-induced glutathione depletion and associated mitochondrial lesions, and polyenylphosphatidylcholine opposes the ethanol-induced hepatic phospholipid depletion, the decrease in phosphatidylethanolamine methyltransferase activity and the activation of hepatic lipocytes, with full prevention of ethanol-induced septal fibrosis and cirrhosis; its dilinoleoyl species also increases collagenase activity in lipocytes. "
|2.||Hepatocellular Carcinoma (Hepatoma)
08/01/2009 - "We previously established a line of phosphatidylethanolamine N-methyltransferase 2 (pemt2) -stably transfected CBRH-7919 hepatoma cells, and showed that pemt2 over-expression inhibited cell proliferation and induced apoptosis. "
01/01/2003 - "Expression of phosphatidylethanolamine N-methyltransferase in human hepatocellular carcinomas."
08/01/2000 - "[Comparison of the expression and activity of phosphatidylethanolamine N-methyltransferase 2 between primary cultured hepatocytes and hepatoma cells in rats]."
05/17/1997 - "Expression of phosphatidylethanolamine N-methyltransferase (PEMT)-2 in rat hepatoma cells caused an increase in the time for cell division from 18 to 50 h [Cui et al. (1994) J. "
12/15/1995 - "Phosphatidylethanolamine N-methyltransferase-2 (PEMT2) of rat liver was expressed in McArdle-RH7777 rat hepatoma cells, which lack endogenous PEMT activity. "
09/01/2015 - "Mice that lack phosphatidylethanolamine N-methyltransferase (Pemt(-/-) mice) are protected from high-fat (HF) diet-induced obesity. "
02/01/2015 - "Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice."
04/01/2015 - "Vagus nerve contributes to the development of steatohepatitis and obesity in phosphatidylethanolamine N-methyltransferase deficient mice."
02/01/2015 - "Mice lacking phosphatidylethanolamine N-methyltransferase (PEMT, Pemt(-/-) mice) are resistant to high-fat diet (HFD)-induced obesity (DIO) but develop non-alcoholic steatohepatitis. "
01/11/2013 - "Biosynthesis of hepatic choline via phosphatidylethanolamine N-methyltransferase (PEMT) plays an important role in the development of type 2 diabetes and obesity. "
|4.||Alcoholic Liver Diseases (Alcoholic Liver Disease)
11/01/2001 - "Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for administration of the products of the reaction. "
12/01/2000 - "Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for the administration of the products of the reaction. "
01/01/2000 - "Similarly, decreased phosphatidylethanolamine methyltransferase activity is associated with alcoholic liver disease, resulting in phosphatidylcholine depletion and serious consequences for the integrity of membranes. "
05/01/1998 - "Sexually dimorphic activation of liver and brain phosphatidylethanolamine N-methyltransferase by dietary choline deficiency."
01/01/2015 - "Both choline deficiency and low hepatic phosphatidylethanolamine N-methyltransferase (PEMT) activity are associated with hepatic lipidosis (HL) in humans, mice and rats. "
03/01/2011 - "More than one-half of premenopausal women may be resistant to choline deficiency-induced organ dysfunction, because estrogen induces the gene [phosphatidylethanolamine-N-methyltransferase (PEMT)] that catalyzes endogenous synthesis of phosphatidylcholine, which can subsequently yield choline. "
|3.||Glutathione (Reduced Glutathione)
|4.||Ethanol (Ethyl Alcohol)
|7.||Choline (Choline Chloride)
|10.||Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)