Dimethylglycine Dehydrogenase

A FLAVOPROTEIN enzyme that catalyzes the oxidative demethylation of dimethylglycine to SARCOSINE and FORMALDEHYDE.

Also Known As:

Dehydrogenase, Dimethylglycine; N,N-dimethylglycine oxidoreductase

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxidoreductases Acting on CH-NH Group Donors
      - N-Demethylating Oxidoreductases: 18
        Dimethylglycine Dehydrogenase: 5
        human DMGDH protein
        mouse Dmgdh protein
        rat Dmgdh protein

Experts

1.	Li, Junjian: 1 article (01/2019)
2.	Sun, Yunpeng: 1 article (01/2019)
3.	Yu, Zhengping: 1 article (01/2019)
4.	Zhao, Chang: 1 article (01/2019)
5.	Zhou, Qingqing: 1 article (01/2019)
6.	Zhu, Qiandong: 1 article (01/2019)
7.	Castaño, Gustavo O: 1 article (01/2017)
8.	Mirshahi, Faridodin: 1 article (01/2017)
9.	Pirola, Carlos J: 1 article (01/2017)
10.	Puri, Puneet: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 05/31/2016 - "In our work, we performed RNA-seq for50 pairs of normal-tumor of hepatocellular carcinoma (HCC) samples and found that the expression of dimethylglycine dehydrogenase (DMGDH) is decreased in HCC. " 11/01/2014 - "Therefore, 7 genes were selected from our previous study, which encoded interleukin 32 (IL-32), lysosomal H+ transporting ATPase, V0 subunit d2 (ATP6V0D2), tumor necrosis factor receptor superfamily, member 9 (TNFRSF9), amphiregulin, schwannoma-derived growth factor (AREG), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3), PRR5-ARHGAP8 (LOC553158) and dimethylglycine dehydrogenase (DMGDH), and their expression was examined in human clinical specimens from patients with cancer. "
2.	Leukemia 11/01/2014 - "Therefore, 7 genes were selected from our previous study, which encoded interleukin 32 (IL-32), lysosomal H+ transporting ATPase, V0 subunit d2 (ATP6V0D2), tumor necrosis factor receptor superfamily, member 9 (TNFRSF9), amphiregulin, schwannoma-derived growth factor (AREG), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3), PRR5-ARHGAP8 (LOC553158) and dimethylglycine dehydrogenase (DMGDH), and their expression was examined in human clinical specimens from patients with cancer. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2019 - "Expressions of RP11-422N16.3, miR-23b-3p and dimethylglycine dehydrogenase (DMGDH) were determined in liver cancer tissues, adjacent normal tissues, hepatocellular carcinoma cell lines and normal liver epithelial cell line. " 05/31/2016 - "Potential diagnostic and prognostic marker dimethylglycine dehydrogenase (DMGDH) suppresses hepatocellular carcinoma metastasis in vitro and in vivo." 05/31/2016 - "In our work, we performed RNA-seq for50 pairs of normal-tumor of hepatocellular carcinoma (HCC) samples and found that the expression of dimethylglycine dehydrogenase (DMGDH) is decreased in HCC. "
4.	Non-alcoholic Fatty Liver Disease 01/01/2017 - "We also explored the association between a missense rs1805074, p.Ser646Pro variant in DMGDH (dimethylglycine dehydrogenase mitochondrial) and NAFLD severity (n=390). "
5.	Neoplasm Metastasis (Metastasis) 05/31/2016 - "Potential diagnostic and prognostic marker dimethylglycine dehydrogenase (DMGDH) suppresses hepatocellular carcinoma metastasis in vitro and in vivo."

Related Drugs and Biologics

1.	Amphiregulin
2.	Member 9 Tumor Necrosis Factor Receptor Superfamily
3.	Interleukins
4.	Adenosine Triphosphatases (ATPase)
5.	RNA (Ribonucleic Acid)