CREB-Binding Protein

A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME.

Also Known As:

Networked: 274 relevant articles (4 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wright, Peter E: 5 articles (12/2021 - 01/2004)
2.	Barco, Angel: 4 articles (01/2014 - 06/2004)
3.	Dyson, H Jane: 3 articles (12/2021 - 01/2004)
4.	Wang, Jing: 3 articles (10/2018 - 01/2010)
5.	Chen, Rui: 3 articles (01/2017 - 09/2014)
6.	Garcia, Joseph A: 3 articles (01/2017 - 09/2014)
7.	Xu, Min: 3 articles (01/2017 - 09/2014)
8.	Brindle, Paul K: 3 articles (01/2016 - 11/2005)
9.	Rebel, Vivienne I: 3 articles (01/2016 - 01/2012)
10.	Latchman, David S: 3 articles (02/2007 - 02/2003)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/2021 - "High-altitude deer mouse hypoxia-inducible factor-2α shows defective interaction with CREB-binding protein." 05/17/2013 - "Homeostatic response to hypoxia is primarily mediated by hypoxia inducible factor (HIF)-1α that elicits transcriptional activity through recruitment of the CREB binding protein (CBP)/p300 coactivator. " 01/22/2010 - "Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300." 01/01/2000 - "The hypoxia-inducible activity of both these domains was enhanced by either SRC-1 or the CREB-binding protein (CBP)/p300 coactivator. " 01/01/2000 - "Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha."
2.	Vascular Remodeling 01/01/2022 - "Pharmacological inhibition of the P300/CREB-binding protein complex reduced the remodeling of distal pulmonary vessels, improved hemodynamics, and reversed established PAH in three rodent models in vivo, as well as reduced vascular remodeling in precision-cut tissue slices from human PAH lungs ex vivo. "
3.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2023 - "Activation of CREB-binding protein ameliorates spinal cord injury in tabersonine treatment by suppressing NLRP3/Notch signaling."
4.	Infections 01/01/2023 - "This study aims to find the molecular mechanism that mediates HBV infection and induces TGF-β2 and verifies that CREB binding protein acetylation mediates HBV infection and induces TGF-β2 expression. " 04/01/2005 - "In this study, we demonstrate that IRF3 and IRF7, which with the coactivators CREB-binding protein and P300 form the virus-activated factor (VAF) complex upon Sendai virus infection, bind to the IRF7 ISRE and IRFE and can directly activate IRF7 transcription. " 02/01/2005 - "Other signs of IRF-3 activation such as hyperphosphorylation, homodimer formation, and recruitment of the coactivator CREB-binding protein (CBP) were found late after infection with the control virus but not with SARS-CoV. " 01/01/2019 - "nucleatum infection, compared with the control group (paracancerous tissues), while other genes associated with signaling pathways in cancer, including CREB-binding protein (CREBBP), STAT1, PRKACB, CAMK2B, JUN, TP53 and EWSR1, were dysregulated. " 12/28/2015 - "C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection."
5.	Neoplasms (Cancer) 04/01/2010 - "CREB-binding protein (CBP) is involved in the apoptotic pathway in several tumor cells, however, little is known whether CBP is associated with apoptosis in ECs and the apoptotic effect of CBP on ECs is regulated by NO. Therefore, the purpose of the present study was to investigate whether silencing CBP expression could affect the sensitivity of ECs toward apoptotic stimuli and determined the role of NO. In this study, we found that when CBP expression was silenced by RNA interference, ECs were more prone to apoptosis under serum deprivation, whereas the apoptosis was not significantly induced in the serum-containing condition. " 01/01/2017 - "Overexpression of the CREB-binding protein (CBP), a bromodomain-containing transcription coactivator involved in a variety of cellular processes, has been observed in several types of cancer with a correlation to aggressiveness. " 04/01/2012 - "Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm." 05/07/2004 - "We recently reported that MDM2, a negative feedback regulator of the tumor suppressor p53, inhibits p300/CREB-binding protein-associated factor (PCAF)-mediated p53 acetylation. " 09/01/2002 - "The tumor suppressors p300 and CREB-binding protein (CBP) are both multifunctional transcriptional coactivators. "

Related Drugs and Biologics

1.	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)
2.	Glucose (Dextrose)
3.	Estrogen Receptors
4.	Small Interfering RNA (siRNA)
5.	A-factor (Streptomyces)
6.	tabersonine
7.	Proteins (Proteins, Gene)
8.	Histone Acetyltransferases (Histone Acetyltransferase)
9.	Carrier Proteins (Binding Protein)
10.	Histones (Histone)

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Moxibustion
4.	Ligation