Synaptotagmin I

A vesicular transport protein expressed predominately in NEURONS. Synaptotagmin helps regulate EXOCYTOSIS of SYNAPTIC VESICLES and appears to serve as a calcium sensor to trigger NEUROTRANSMITTER release. It also acts as a nerve cell receptor for certain BOTULINUM TOXINS.

Also Known As:

Synaptic Vesicle Protein p65; Synaptotagmin 1; p65 Protein (Synaptotagmin I)

Networked: 51 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Calcium-Binding Proteins: 1333
      - Synaptotagmins: 129
        Synaptotagmin I: 51
        Arabidopsis SYT1 protein
        human SYT1 protein
        mouse Syt1 protein
        rat Syt1 protein
  - Membrane Proteins: 10078
    - Vesicular Transport Proteins: 1
      - Synaptotagmins: 129
        Synaptotagmin I: 51
        Arabidopsis SYT1 protein
        human SYT1 protein
        mouse Syt1 protein
        rat Syt1 protein

Experts

1.	Zhao, Ming: 7 articles (04/2011 - 08/2006)
2.	Fang, Wei: 6 articles (04/2011 - 08/2006)
3.	Brindle, Kevin M: 5 articles (12/2020 - 11/2007)
4.	Wang, Feng: 5 articles (04/2011 - 02/2007)
5.	Zhu, Xiaoguang: 5 articles (11/2007 - 08/2006)
6.	Li, Yan: 3 articles (01/2021 - 05/2007)
7.	Hu, De-En: 3 articles (12/2020 - 03/2008)
8.	Ji, Shundong: 3 articles (04/2008 - 08/2006)
9.	Neves, André A: 2 articles (12/2020 - 01/2017)
10.	Soloviev, Dmitry: 2 articles (12/2020 - 01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "Rapid Imaging of Tumor Cell Death In Vivo Using the C2A Domain of Synaptotagmin-I." 11/03/2023 - "Although synaptotagmin 1 (SYT1) has been identified participating in a variety of cancers, its role in colorectal cancer (CRC) remains an enigma. " 01/01/2018 - "The tumor localization and pharmacokinetics of several phosphatidylserine-specific Fc fusions have been analyzed in mice and demonstrate that Fc-Syt1, a fusion containing the synaptotagmin 1 C2A domain, effectively targets tumor tissue. " 11/03/2023 - "Synaptotagmin 1 Suppresses Colorectal Cancer Metastasis by Inhibiting ERK/MAPK Signaling-Mediated Tumor Cell Pseudopodial Formation and Migration." 04/01/2008 - "Imaging paclitaxel (chemotherapy)-induced tumor apoptosis with 99mTc C2A, a domain of synaptotagmin I: a preliminary study."
2.	Cognitive Dysfunction 04/01/2007 - "Age-related spatial cognitive impairment is correlated with increase of synaptotagmin 1 in dorsal hippocampus in SAMP8 mice." 01/01/2021 - "This study revealed that exosomal GAP43, neurogranin, SNAP25, and synaptotagmin 1 act as effective biomarkers for prediction of AD 5 to 7 years before cognitive impairment."
3.	Drug Resistant Epilepsy 06/01/2009 - "Further studies will be required to elucidate the mechanism by which Synaptotagmin I plays role in refractory epilepsy." 06/01/2009 - "These findings provide new information in the epileptogenesis of refractory epilepsy, and suggest that Synaptotagmin I might be involved in human refractory epilepsy. " 06/01/2009 - "The expression of Synaptotagmin I in refractory epilepsy group was significantly higher than that in the control and non-refractory epilepsy groups. " 06/01/2009 - "Altered expression of synaptotagmin I in temporal lobe tissue of patients with refractory epilepsy." 06/01/2009 - "We aimed to investigate Synaptotagmin I expression in the anterior temporal neocortex of epilepsy patients, and to explore the possible role of Synaptotagmin I in refractory epilepsy. "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 06/01/2007 - "Based on our prior finding that the (99m)Tc-labeled C2A domain of synaptotagmin I accumulates intensely in the area at risk, this study quantitatively characterized the temporal and spatial distribution of the radiotracer in a rat model of myocardial ischemia and reperfusion. "
5.	Sexually Transmitted Diseases (Sexually Transmitted Disease) 01/01/1999 - "In this study, we examined the function of Syt I/II in neurite outgrowth in cultured chick dorsal root ganglion neurons using an anti-synaptotagmin I and II C2A domain (anti-STI/II-C2A) antibody that inhibits Ca2+-regulated exocytosis. " 01/01/1999 - "Immunoblots confirmed the high specificity of the anti-STI/II-C2A antibody and showed the expression of synaptotagmin I or II in chick dorsal root ganglion neurons. "

Related Drugs and Biologics

1.	Neurogranin
2.	Paclitaxel (Taxol)
3.	Biomarkers (Surrogate Marker)
4.	Synaptotagmins (Synaptotagmin)
5.	AD 5
6.	Proteins (Proteins, Gene)
7.	Phosphatidylserines
8.	Peroxiredoxins
9.	Lysosomal-Associated Membrane Protein 1
10.	Uracil-DNA Glycosidase

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Electroacupuncture
3.	Therapeutics