Synaptotagmin II

A vesicular transport protein that was originally characterized as an inositol polyphosphate binding protein. Synaptotagmin II helps regulate EXOCYTOSIS of SYNAPTIC VESICLES and appears to serve as a calcium sensor to trigger NEUROTRANSMITTER release. It also acts as a nerve cell receptor for certain BOTULINUM TOXINS.

Also Known As:

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Horvath, Rita: 3 articles (01/2017 - 09/2014)
2.	Lochmüller, Hanns: 3 articles (01/2017 - 09/2014)
3.	Whittaker, Roger G: 3 articles (01/2017 - 09/2014)
4.	Ferns, Michael: 2 articles (01/2021 - 01/2020)
5.	Maselli, Ricardo A: 2 articles (01/2021 - 01/2020)
6.	Almodovar, Jorge L: 2 articles (12/2015 - 09/2014)
7.	Bansagi, Boglarka: 2 articles (12/2015 - 09/2014)
8.	Herrmann, David N: 2 articles (12/2015 - 09/2014)
9.	Littleton, J Troy: 2 articles (12/2015 - 09/2014)
10.	Sowden, Janet E: 2 articles (12/2015 - 09/2014)

Related Diseases

1.	Congenital Myasthenic Syndromes (Myasthenia Gravis, Congenital) 01/01/2021 - "We studied a patient with a congenital myasthenic syndrome (CMS) caused by a dominant mutation in the synaptotagmin 2 gene (SYT2) and compared the clinical features of this patient with those of a previously described patient with a recessive mutation in the same gene. " 12/01/2020 - "To report the identification of 2 new homozygous recessive mutations in the synaptotagmin 2 (SYT2) gene as the genetic cause of severe and early presynaptic forms of congenital myasthenic syndromes (CMSs). " 01/01/2020 - "Defects in the gene encoding synaptotagmin 2 (SYT2) have been linked to a presynaptic congenital myasthenic syndrome (CMS) and motor neuropathies. " 09/04/2014 - "In addition, mutations in the Synaptotagmin 2 C2B domain represent an important cause of presynaptic congenital myasthenic syndromes and link them with hereditary motor axonopathies. " 01/01/2017 - "Synaptotagmin 2, the Ca2+ sensor for fast, synchronized neurotransmitter release at the human neuromuscular junction, has recently been implicated in a dominantly inherited congenital myasthenic syndrome associated with a non-progressive motor neuropathy. "
2.	Chronic Pain 01/01/2015 - "In support of this hypothesis, we show here that up-regulation of a gene involved with synaptic function, Synaptotagmin II (syt2), in the PFC in a chronic pain model is associated with long-term changes in DNA methylation. " 04/18/2013 - "Several of the changes detected by RNAseq were validated by RT-QPCR and included transcripts with known roles in chronic pain and/or neuronal plasticity including the NMDA receptor (glutamate receptor, ionotropic, NMDA; grin1), neurite outgrowth (roundabout 3; robo3), gliosis (glial fibrillary acidic protein; gfap), vesicular release (synaptotagmin 2; syt2), and neuronal excitability (voltage-gated sodium channel, type I; scn1a). "
3.	Lambert-Eaton Myasthenic Syndrome (Lambert-Eaton Syndrome) 09/04/2014 - "Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy."
4.	Neuroblastoma 01/15/2012 - "The activity drastically alters the behavior of a range of cultured cells including the neuroblastoma cell line SH-SY5Y and primary cortical mouse neurons, and, since the sequence is conserved also in synaptotagmin 2, it may reflect an important fine-tuning role for these two proteins during synaptic vesicle fusion and neurotransmitter release."
5.	Neoplasms (Cancer) 09/01/2002 - "Rat basophilic leukemia cells (RBL-2H3), a tumor analogue of mucosal mast cells (MMC), express at least four distinct Syt homologues, including Syt II, Syt III, Syt V and Syt IX. Synaptotagmin II is located at the late/endosomal/lysosomal compartment, where it negatively regulates lysosomal exocytosis. "

Related Drugs and Biologics

1.	Neurotransmitter Agents (Neurotransmitter)
2.	Voltage-Gated Sodium Channels
3.	Ionotropic Glutamate Receptors
4.	N-Methylaspartate (NMDA)
5.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
6.	Proteins (Proteins, Gene)
7.	Glial Fibrillary Acidic Protein
8.	Acetylcholine (Acetylcholine Chloride)