HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)

An interferon regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral infection. PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA, and activates transcription.
Also Known As:
Interferon Regulatory Factor 3; IFN-Regulatory Factor 3; IFN Regulatory Factor 3; IRF 3 Transcription Factor; Transcription Factor, IRF-3; IRF-3 Transcription Factor
Networked: 224 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gale, Michael: 12 articles (02/2014 - 07/2004)
2. Hiscott, John: 10 articles (06/2009 - 06/2002)
3. Grandvaux, Nathalie: 9 articles (01/2014 - 06/2002)
4. Akira, Shizuo: 8 articles (02/2014 - 10/2004)
5. Lin, Rongtuan: 7 articles (06/2009 - 06/2002)
6. Fujita, Takashi: 6 articles (08/2015 - 06/2002)
7. Barber, Glen N: 6 articles (11/2014 - 06/2002)
8. Servant, Marc J: 6 articles (01/2014 - 06/2002)
9. Zhong, Bo: 5 articles (03/2015 - 07/2007)
10. Xu, Hua-Guo: 5 articles (04/2014 - 10/2010)

Related Diseases

1. Multiple Sclerosis
2. Thyroiditis
3. Infection
4. Bites and Stings (Sting)
5. Necrosis
08/01/2011 - "A20 [also known as TNFAIP3 (tumour necrosis factor α-induced protein 3)] restricts and terminates inflammatory responses through modulation of the ubiquitination status of central components in NF-κB (nuclear factor κB), IRF3 (interferon regulatory factor 3) and apoptosis signalling cascades. "
02/01/2006 - "Furthermore, in subsequent dot-blotting immunoanalysis of glutathione S-transferase and tumour necrosis factor-alpha, and immunofluorescent microscopy assay of interferon regulatory factor 3, the chimaeric protein enabled effective detection of target molecules. "
06/15/2015 - "In the present study, we found that BI-2536 is likely to exert this effect by preventing the interaction of the transcription factors IRF3 (interferon-regulatory factor 3) and c-Jun with the IFNB promoter, but without affecting the TBK1 {TANK [TRAF (tumour-necrosis-factor-receptor-associated factor)-associated nuclear factor κB activator]-binding kinase 1}-catalysed phosphorylation of IRF3 at Ser³⁹⁶, the dimerization and nuclear translocation of IRF3 or the phosphorylation of c-Jun and ATF2 (activating transcription factor 2). "
03/01/2014 - "Moreover, it was found that paxilline substantially inhibited HS-induced activation of several different transcription factors in macrophages, including nuclear factor-κB, p38 and interferon regulatory factor-3, followed by decreased production of tumour necrosis factor-α and interferon-β. "
05/01/2014 - "The expression of mRNA transcripts of the antiviral immune-related molecules interferon regulatory factor-3 I(ir3), interferon regulatory factor-7 (irf7), melanoma differentiation-associated protein 5 (mda5) was obviously up-regulated in LYCK cells in response to the stimulation with poly (I:C), whereas the expression of mRNA transcripts of the inflammatory cytokines tumour necrosis factor-α2 (tnfTNF-α2), interleukin-8 (il8), CC chemokine (lycCC) was up-regulated by lipopolysaccharide. "

Related Drugs and Biologics

1. Interferons
2. Toll-Like Receptor 3
3. phenyl methimazole
4. Transcription Factors (Transcription Factor)
5. Phosphotransferases (Kinase)
6. NF-kappa B (NF-kB)
7. I-kappa B Kinase
8. 5,6-dimethylxanthenoneacetic acid
9. Activating Transcription Factor 2
10. Transcription Factor AP-1 (Transcription Factor AP 1)

Related Therapies and Procedures

1. Intraperitoneal Injections