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Interferon Regulatory Factors

A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.
Also Known As:
IRF Transcription Factors; Transcription Factors, IRF
Networked: 75 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Anselmo, Anna: 2 articles (01/2014 - 01/2013)
2. Botti, Sara: 2 articles (01/2014 - 01/2013)
3. Badaoui, Bouabid: 2 articles (01/2014 - 01/2013)
4. Lin, Rongtuan: 2 articles (01/2011 - 04/2002)
5. Hiscott, John: 2 articles (01/2011 - 04/2002)
6. Noyce, Ryan S: 2 articles (09/2010 - 02/2004)
7. Mossman, Karen L: 2 articles (09/2010 - 02/2004)
8. Barber, G N: 2 articles (02/2001 - 02/2001)
9. Grant, C E: 2 articles (12/2000 - 09/2000)
10. May, D L: 2 articles (12/2000 - 09/2000)

Related Diseases

1. Infection
2. Melanoma (Melanoma, Malignant)
05/01/2010 - "They significantly increased the intracellular concentration of active nuclear transcription factor nuclear factor kappa B (NF-kappaB), interferon regulatory factors (IRF)-3, and IRF-7 and significantly decreased melanoma differentiation-associated protein-5 (MDA-5) and p38. "
08/01/2009 - "Recently, novel cytosolic DNA sensors have been uncovered that include ZBP1 or DNA-dependent activator of interferon-regulatory factors (DAI) and a DNA sensing inflammasome consisting of the HIN200 protein, absent in melanoma 2 (AIM2). "
09/01/2009 - "DNA-dependent activator of interferon regulatory factors (DAI) and absent in melanoma (AIM)2 were recently identified as cytosolic DNA sensors that respond with the release of type I interferon and proinflammatory cytokines. "
10/01/2013 - "The aim of this study is to determine the expression of bacterial DNA sensors, including Toll-like receptor 9 (TLR-9), DNA-dependent activator of interferon-regulatory factors (DAI), and absent in melanoma 2 (AIM2) in chronic periodontitis (CP versus healthy) (H) tissues. "
06/15/2013 - "Unstimulated normal cells were found to express mRNA for melanoma differentiation associated gene 5 (MDA5), retinoic acid-inducible gene I (RIG-I), DNA-dependent activation of interferon regulatory factors, leucine rich repeat flightless interacting protein 1, and interferon inducible gene 16 (IFI16), as well as their adaptor molecules myeloid differentiation primary response gene 88, interferon-β promoter stimulator 1, and endoplasmic reticulum-resident transmembrane protein stimulator of interferon genes. "
3. Inflammation
4. Systemic Lupus Erythematosus (Libman-Sacks Disease)
5. Chronic Periodontitis

Related Drugs and Biologics

1. Interferons
2. Interferon Type I
3. Toll-Like Receptors (Toll-Like Receptor)
4. Proteins (Proteins, Gene)
5. Virulence Factors (Pathogenicity Factors)
6. Toll-Like Receptor 9
7. DNA (Deoxyribonucleic Acid)
8. Tretinoin (Retinoic Acid)
9. Phosphotransferases (Kinase)
10. Bacterial DNA