Suppressor of Cytokine Signaling Proteins

A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.

Also Known As:

Networked: 116 relevant articles (4 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Egwuagu, Charles E: 4 articles (04/2015 - 01/2006)
2.	Gomez-Guerrero, Carmen: 3 articles (01/2020 - 05/2010)
3.	Yoshimura, Akihiko: 3 articles (01/2018 - 06/2009)
4.	Lee, Yun Sang: 3 articles (04/2015 - 06/2008)
5.	Yu, Cheng-Rong: 3 articles (04/2015 - 06/2008)
6.	Kubo, Masato: 3 articles (06/2009 - 02/2006)
7.	Kahn, C Ronald: 3 articles (10/2005 - 06/2004)
8.	Ueki, Kohjiro: 3 articles (10/2005 - 06/2004)
9.	Liu, Jun: 2 articles (06/2021 - 07/2010)
10.	Chen, Shun: 2 articles (01/2021 - 01/2020)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2019 - "In the current study, we found that suppressor of cytokine signaling proteins 3 (SOCS3) possessed the tumor suppressive activity against the JAK2 V617F mutant-provoked cellular transformation. " 07/25/2007 - "Recent in vivo and in vitro studies suggest that SOCS proteins are also implicated in cancer. " 01/01/2021 - "SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer." 01/01/2015 - "The immunohistochemistry result for SOCS proteins in human cervical tissue also confirmed that normal tissue expressed higher level of SOCS proteins than neighboring tumor. " 01/01/2013 - "As a consequence of their regulatory properties, SOCS proteins have important functions in development and homeostasis, with increasing recognition of their role in disease, particularly their tumor suppressor and anti-inflammatory functions. "
2.	Inflammation (Inflammations) 05/01/2011 - "Studies have shown that SOCS proteins are key physiological regulators of inflammation. " 05/04/2015 - "Secretion and transcellular delivery of vesicular SOCS proteins thus represent a new model for the control of inflammatory signaling, which is subject to dysregulation during states of inflammation." 09/01/2010 - "Chronic inflammation is associated with altered growth and skeletal development, and it is possible that SOCS proteins may have an important role to play in mediating these effects." 11/01/2002 - "Inflammation induces the expression of SOCS proteins. " 03/01/2016 - "To date, the roles of SOCS proteins in inflammation, autoimmunity and cancer have been comprehensively illustrated; however, only a limited number of studies focused on their role in wound healing. "
3.	Infections 02/01/2006 - "The results suggest that induction of SOCS proteins within phagocytes due to infection with T. " 03/01/2011 - "SOCS proteins can define host susceptibility to infection, contribute to peripheral disease manifestations such as immune dysfunction and cancer, and even modify the efficacy of therapeutic interventions. " 01/01/2018 - "As viral overexpression of SOCS proteins exacerbates infection with other viruses, they may also enhance cytomegalovirus infection. " 10/01/2016 - "Previous studies reported the involvement of suppressor of cytokine signaling (SOCS) proteins, specifically SOCS1 and SOCS3, in HSV-1 infection, suggesting that other members of this family could be involved in the immune response against HSV-1. " 04/01/2011 - "In this study, we investigated how HCV infection modulates SOCS-1 and SOCS-3 production and how these SOCS proteins affect hepcidin production. "
4.	Cytomegalovirus Retinitis 01/01/2018 - "Alternatively, the immunosuppressive effect of SOCS proteins may be protective against immunopathology during cytomegalovirus retinitis, and in such a case SOCS mimetics or overexpression treatment strategies might be used to combat this disease. "
5.	Prostatic Neoplasms (Prostate Cancer) 05/01/2017 - "In a recent report we analyzed the methylathion status of cytokine signaling (SOCS) proteins 3 (SOCS3) gene and the consequences of promoter hypermethylation on mRNA and protein expression in a collection of prostate cancer and benign prostate hyperplasia (BPH) and for the first time we demonstrated that a hypermethylation of SOCS3 with a significant reduction of its mRNA and protein expression identifies a subgroup of prostate cancer with a more aggressive behavior. "

Related Drugs and Biologics

1.	Cytokines
2.	Proteins (Proteins, Gene)
3.	Messenger RNA (mRNA)
4.	Peptides (Polypeptides)
5.	Hepcidins
6.	Biomarkers (Surrogate Marker)
7.	Insulin (Novolin)
8.	Janus Kinases
9.	Phosphotransferases (Kinase)
10.	Cullin Proteins (Cullins)

Related Therapies and Procedures

1.	Therapeutics
2.	Moxibustion
3.	Enteral Nutrition (Feeding, Tube)