POU Domain Factors

A family of transcription factors characterized by the presence of a bipartite DNA-binding domain known as the POU domain. The POU domain contains two subdomains, a POU-specific domain and a POU-homeodomain. The POU domain was originally identified as a region of approximately 150 amino acids shared between the Pit-1, Oct-1, Oct-2, and Unc-86 transcription factors.

Also Known As:

Networked: 19 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Latchman, David S: 2 articles (04/2005 - 07/2002)
2.	Abdullah, Mohamed: 1 article (01/2022)
3.	Avbelj Stefanija, Magdalena: 1 article (01/2022)
4.	Babiker, Omer: 1 article (01/2022)
5.	Battelino, Tadej: 1 article (01/2022)
6.	Cao, Lili: 1 article (01/2022)
7.	Chai, Xiaoxue: 1 article (01/2022)
8.	Ding, Xuchao: 1 article (01/2022)
9.	Du, Juan: 1 article (01/2022)
10.	Hassan, Samar S: 1 article (01/2022)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 11/01/2019 - "We have previously shown that the transcription factor POU class 1 homeobox 1 (POU1F1), also known as Pit-1, induces profound changes on neoplastic cell-autonomous processes favoring metastasis in human breast cancer. " 04/15/2005 - "In this study, we show a strong correlation between elevated levels of the Brn-3b POU transcription factor and high levels of HSP-27 protein in manipulated MCF-7 breast cancer cells as well as in human breast biopsies. "
2.	Infections 09/06/2013 - "This study demonstrates that a large number of genes that are activated by NF-κB/Relish in response to infection are normally repressed by the evolutionarily conserved Oct/POU transcription factor Nub. "
3.	Neoplasms (Cancer) 12/12/2002 - "Expression of the POU transcription factor Brn-3a is regulated spatially and temporally during embryogenesis and can be detected in a particular subset of neurons and neuronal tumors. " 01/01/2007 - "The importance of POU proteins as developmental regulators and tumor-promoting agents is due to linker flexibility, which allows them to adapt to a considerable variety of DNA targets. " 12/01/2008 - "Aberrant levels of POU proteins have been found in several malignancies, including melanoma, connecting the otherwise developmentally restricted gene regulatory functions of POU transcription factors to the critical determinants of malignant transformation. " 01/01/2020 - "We characterised the role of CSN6 in regulating cancer stemness, which involves the TRIM21 E3 ubiquitin ligase, transcription factor POU class 2 homeobox 1 (OCT1) and cancer stem cell marker aldehyde dehydrogenase 1 A1 (ALDH1A1). " 09/01/2007 - "These cells expressed markers characteristic of pluripotent stem cells, including alkaline phosphatase, stage-specific embryonic antigens (SSEA)-1, SSEA-3, SSEA-4, tumor related antigens (TRA)-1-60, TRA-1-81, and the POU transcription factor Octamer-4 (Oct-4). "
4.	Melanoma (Melanoma, Malignant) 01/01/2014 - "Here, the POU transcription factor family and its role in melanocytic transformation and melanoma are reviewed. " 12/01/2008 - "Aberrant levels of POU proteins have been found in several malignancies, including melanoma, connecting the otherwise developmentally restricted gene regulatory functions of POU transcription factors to the critical determinants of malignant transformation. "
5.	Hearing Loss (Hearing Impairment) 01/01/2014 - "Brn4, which encodes a POU transcription factor, is the gene responsible for DFN3, an X chromosome-linked, non-syndromic type of hearing loss. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Stage-Specific Embryonic Antigens
3.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
4.	Oncogene Proteins (Oncogene Protein)
5.	Transcription Factors (Transcription Factor)
6.	Thyrotropin (Thyroid-Stimulating Hormone)
7.	Growth Hormone (Somatotropin)
8.	Prolactin
9.	Hormones (Hormone)
10.	DNA (Deoxyribonucleic Acid)