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D-Aspartate Oxidase

An FAD-dependent peroxisomal flavoenzyme, this catalyzes the oxidative deamination of D-ASPARTATE to OXALOACETATE and AMMONIA using oxygen as electron acceptor.
Also Known As:
Aspartic Oxidase; D-aspartic Oxidase; D Aspartate Oxidase; D aspartic Oxidase; Oxidase, Aspartic; Oxidase, D-Aspartate; Oxidase, D-aspartic
Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Bertolino, A: 1 article (01/2015)
2. Keller, S: 1 article (01/2015)
3. Vitucci, D: 1 article (01/2015)
4. Napolitano, F: 1 article (01/2015)
5. Chiariotti, L: 1 article (01/2015)
6. D'Argenio, V: 1 article (01/2015)
7. de Bartolomeis, A: 1 article (01/2015)
8. Guerri, G: 1 article (01/2015)
9. Iasevoli, F: 1 article (01/2015)
10. Di Maio, A: 1 article (01/2015)

Related Diseases

1. Dyskinesias (Dyskinesia)
2. Schizophrenia (Dementia Praecox)
3. Zellweger Syndrome (Zellweger's Syndrome)
4. Prader-Willi Syndrome (Syndrome, Prader-Willi)
03/01/2010 - "Detailed gene expression analysis showed a variety of genes whose upregulation (platelet-derived growth factor receptor alpha polypeptide, solute carrier family 39 member 14, solute carrier family 2 member 3, pleiotrophin, trophinin, pleckstrin and Sec7 domain containing 3, enolase 2, biglycan, SH3 and cysteine-rich domain, matrix metalloproteinases 16) and whose downregulation (tissue inhibitor of metalloproteinase 4, hairy/enhancer of split related with YRPW motif 2, protein tyrosine phosphatase receptor-type Z polypeptide 1, SH3 domain GRB2-like 2, microtubule-associated protein 7, potassium voltage-gated channel shaker-related subfamily member 1, RUN and FYVE domain containing 3, Sin3A-associated protein 18 kDa, proline-rich 4, calcium/calmodulin-dependent protein kinase ID, myeloid/lymphoid or mixed-lineage leukemia translocated to 3, insulin-like growth factor binding protein 5, nucleoside diphosphate-linked moiety X-type motif 9, NudC domain containing 3, imprinted in Prader-Willi syndrome, TAF6-like RNA polymerase II p300/CBP-associated factor 65 kDa, WD repeat and SOCS box-containing 2, adenosine diphosphate ribosylation factor 3, KRR1, proliferation-associated 2G4; CD36, complement component (3b/4b) receptor 1, solute carrier family 4 sodium bicarbonate cotransporter member 4, lipoprotein lipase (LPL), GATA binding protein 3, LPL, glutathione peroxidase 3, D: -aspartate oxidase, apolipoprotein E, sphingomyelin phosphodiesterase acid-like 3A) were associated with poor clinical outcome in terms of development of metastatic or recurrent disease. "
5. Leukemia
03/01/2010 - "Detailed gene expression analysis showed a variety of genes whose upregulation (platelet-derived growth factor receptor alpha polypeptide, solute carrier family 39 member 14, solute carrier family 2 member 3, pleiotrophin, trophinin, pleckstrin and Sec7 domain containing 3, enolase 2, biglycan, SH3 and cysteine-rich domain, matrix metalloproteinases 16) and whose downregulation (tissue inhibitor of metalloproteinase 4, hairy/enhancer of split related with YRPW motif 2, protein tyrosine phosphatase receptor-type Z polypeptide 1, SH3 domain GRB2-like 2, microtubule-associated protein 7, potassium voltage-gated channel shaker-related subfamily member 1, RUN and FYVE domain containing 3, Sin3A-associated protein 18 kDa, proline-rich 4, calcium/calmodulin-dependent protein kinase ID, myeloid/lymphoid or mixed-lineage leukemia translocated to 3, insulin-like growth factor binding protein 5, nucleoside diphosphate-linked moiety X-type motif 9, NudC domain containing 3, imprinted in Prader-Willi syndrome, TAF6-like RNA polymerase II p300/CBP-associated factor 65 kDa, WD repeat and SOCS box-containing 2, adenosine diphosphate ribosylation factor 3, KRR1, proliferation-associated 2G4; CD36, complement component (3b/4b) receptor 1, solute carrier family 4 sodium bicarbonate cotransporter member 4, lipoprotein lipase (LPL), GATA binding protein 3, LPL, glutathione peroxidase 3, D: -aspartate oxidase, apolipoprotein E, sphingomyelin phosphodiesterase acid-like 3A) were associated with poor clinical outcome in terms of development of metastatic or recurrent disease. "

Related Drugs and Biologics

1. Biglycan
2. Class 5 Receptor-Like Protein Tyrosine Phosphatases
3. Sarcosine Oxidase
4. Sodium-Bicarbonate Symporters
5. Matrix Metalloproteinases
6. Insulin-Like Growth Factor Binding Protein 5
7. Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)
8. Sphingomyelin Phosphodiesterase (Sphingomyelinase)
9. RNA Polymerase II (RNA Polymerase B)
10. Protein Kinases (Protein Kinase)