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STAT5 Transcription Factor

A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.
Also Known As:
Mammary Gland Factor; Mammary Gland-Specific Nuclear Factor; STAT5 Protein; STAT5a Protein; STAT5a Transcription Factor; STAT5alpha Protein; STAT5b Protein; STAT5b Transcription Factor; STAT5beta Protein; Signal Transducer and Activator of Transcription 5; Signal Transducer and Activator of Transcription 5A; Signal Transducer and Activator of Transcription 5B; Factor, STAT5 Transcription; Mammary Gland Specific Nuclear Factor; Transcription Factor, STAT5; Transcription Factor, STAT5a; Transcription Factor, STAT5b
Networked: 132 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Nevalainen, Marja T: 12 articles (06/2013 - 07/2003)
2. Rui, Hallgeir: 7 articles (06/2013 - 07/2003)
3. Silva, Corinne M: 7 articles (01/2009 - 11/2005)
4. Dagvadorj, Ayush: 4 articles (06/2013 - 01/2008)
5. Liao, Zhiyong: 4 articles (02/2011 - 01/2008)
6. Xie, Jianwu: 4 articles (12/2010 - 07/2003)
7. Alanen, Kalle: 4 articles (12/2010 - 07/2003)
8. Weaver, Amanda M: 4 articles (08/2008 - 10/2006)
9. Rugowski, Debra E: 3 articles (12/2013 - 12/2004)
10. Schuler, Linda A: 3 articles (12/2013 - 12/2004)

Related Diseases

1. B-Cell Lymphoma (Lymphoma, B Cell)
07/01/2015 - "This prompted us to investigate the effect of constitutively active AKT1 (myristoylated AKT1) in hematopoietic progenitor cells expressing constitutively active signal transducer and activator of transcription 5, Fms-related tyrosine kinase 3-internal tandem duplication, or antiapoptotic B-cell lymphoma 2. Surprisingly, myristoylated AKT1 was incompatible with proliferation driven by both signal transducer and activator of transcription 5 and Fms-related tyrosine kinase 3-internal tandem duplication, which triggered cell cycle block and apoptosis. "
09/01/2014 - "Expression of the Growth Hormone (GH)-stimulated gene Socs2 (Suppressor of Cytokine Signaling 2) is mediated by the transcription activator STAT5 (Signal Transducer and Activator of Transcription 5) and the transcription repressor BCL6 (B-Cell Lymphoma 6). "
10/04/2012 - "BCR-ABL phosphorylates STAP-2 Tyr250 and the phosphorylated STAP-2 in turn upregulated BCR-ABL phosphorylation, leading to enhanced activation of downstream signaling molecules including ERK (extracellular-signal-regulated kinase), STAT5 (signal transducer and activator of transcription 5), BCL-xL (B-cell lymphoma-extra large) and BCL-2(B-cell lymphoma 2). "
01/01/2013 - "Various molecular signals, such as B-cell lymphoma (Bcl)-2, Bcl-2-associated death promoter, Bcl-x, caspase-3, cleaved caspase-3, Fas, signal transducer and activator of transcription 5, extracellular signal-regulated kinases, MMP-9 and pan-janus kinase/stress-activated protein kinase 1, indicated that apoptosis, inhibition of growth and invasion was cleared on sorafenib-eluting PCL films. "
2. Neoplasms (Cancer)
3. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
4. Asthma (Bronchial Asthma)
5. Sarcoma (Soft Tissue Sarcoma)

Related Drugs and Biologics

1. Phosphotransferases (Kinase)
2. Caspase 3 (Caspase-3)
3. sorafenib (BAY 43-9006)
4. Mitogen-Activated Protein Kinase 8
5. Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
6. Tyrosine (L-Tyrosine)
7. Messenger RNA (mRNA)
8. Interleukin-4 (Interleukin 4)
9. montelukast (Singulair)
10. Janus Kinase 2

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Castration