|1.||Nevalainen, Marja T: 12 articles (06/2013 - 07/2003)|
|2.||Rui, Hallgeir: 7 articles (06/2013 - 07/2003)|
|3.||Silva, Corinne M: 7 articles (01/2009 - 11/2005)|
|4.||Dagvadorj, Ayush: 4 articles (06/2013 - 01/2008)|
|5.||Liao, Zhiyong: 4 articles (02/2011 - 01/2008)|
|6.||Xie, Jianwu: 4 articles (12/2010 - 07/2003)|
|7.||Alanen, Kalle: 4 articles (12/2010 - 07/2003)|
|8.||Weaver, Amanda M: 4 articles (08/2008 - 10/2006)|
|9.||Rugowski, Debra E: 3 articles (12/2013 - 12/2004)|
|10.||Schuler, Linda A: 3 articles (12/2013 - 12/2004)|
|1.||B-Cell Lymphoma (Lymphoma, B Cell)
07/01/2015 - "This prompted us to investigate the effect of constitutively active AKT1 (myristoylated AKT1) in hematopoietic progenitor cells expressing constitutively active signal transducer and activator of transcription 5, Fms-related tyrosine kinase 3-internal tandem duplication, or antiapoptotic B-cell lymphoma 2. Surprisingly, myristoylated AKT1 was incompatible with proliferation driven by both signal transducer and activator of transcription 5 and Fms-related tyrosine kinase 3-internal tandem duplication, which triggered cell cycle block and apoptosis. "
09/01/2014 - "Expression of the Growth Hormone (GH)-stimulated gene Socs2 (Suppressor of Cytokine Signaling 2) is mediated by the transcription activator STAT5 (Signal Transducer and Activator of Transcription 5) and the transcription repressor BCL6 (B-Cell Lymphoma 6). "
10/04/2012 - "BCR-ABL phosphorylates STAP-2 Tyr250 and the phosphorylated STAP-2 in turn upregulated BCR-ABL phosphorylation, leading to enhanced activation of downstream signaling molecules including ERK (extracellular-signal-regulated kinase), STAT5 (signal transducer and activator of transcription 5), BCL-xL (B-cell lymphoma-extra large) and BCL-2(B-cell lymphoma 2). "
01/01/2013 - "Various molecular signals, such as B-cell lymphoma (Bcl)-2, Bcl-2-associated death promoter, Bcl-x, caspase-3, cleaved caspase-3, Fas, signal transducer and activator of transcription 5, extracellular signal-regulated kinases, MMP-9 and pan-janus kinase/stress-activated protein kinase 1, indicated that apoptosis, inhibition of growth and invasion was cleared on sorafenib-eluting PCL films. "
03/01/2008 - "Genetic studies in mouse models support a role for the Stat5 transcription factor as a proto-oncogene in mammary tumor initiation. "
01/01/2014 - "STAT5B protein level was also significantly higher in T2a+T2b tumors, reflecting high STAT5B gene expression in this group. "
12/01/2013 - "However, PRL/TGFα-induced heterogeneous ERα+ tumors developed more rapidly in the presence of ICI and contained altered transcripts for surface markers associated with epithelial subpopulations and increased signal transducer and activator of transcription 5b expression. "
01/01/2013 - "Our experiments describe a peptide based inhibitor of Stat5 protein activity which can serve as a lead for the development of a clinically useful compound for cancer treatment. "
07/01/2011 - "Loss of signal transducer and activator of transcription 5a reduces the prevalence of initiation and promotion but does not protect from invasive cancer development. "
|3.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
08/01/2015 - "Signal transducer and activator of transcription 5 (STAT5) is activated in CD34(+)/CD38(-) acute myelogenous leukemia (AML) cells. "
10/01/2012 - "Expression of phosphorylated signal transducer and activator of transcription 5 is associated with an increased risk of death in acute myeloid leukemia."
07/01/2012 - "Activation of the transcription factor STAT5 is essential for the pathogenesis of acute myelogenous leukemia (AML) containing the FLT3 internal tandem duplication (ITD) mutation. "
12/01/2001 - "In the present study, we examined the underlying mechanism, which causes the constitutive tyrosine phosphorylation of signal transducer and activator of transcription 5 (STAT5) in acute myeloid leukemia (AML) blasts. "
04/17/2014 - "Signal transducer and activator of transcription 5 (STAT5) is activated by G-CSF and is hyperactivated in acute myeloid leukemia. "
|4.||Asthma (Bronchial Asthma)
01/01/2012 - "Activation of the transcription factor signal transducer and activator of transcription 5b (STAT5b) is a key event in the development of asthma. "
12/01/2004 - "Activation of signal transducer and activator of transcription 5 (STAT5) in splenocyte proliferation of asthma mice induced by ovalbumin."
02/01/2009 - "To study the expression of signal transducer and activator of transcription 5b (STAT5b) mRNA and interleukin-4 (IL-4) mRNA in blood mononuclearcells in a rat model of asthma and the effect of montelukast (MK) and BCG-polysaccharide and nucleic acid injection (BCG-PSN) on STAT5b mRNA and IL-4 mRNA expression. "
|5.||Sarcoma (Soft Tissue Sarcoma)
10/01/2008 - "Our recent series of studies highlights the critical role of SRC kinase activation (v-src sarcoma viral oncogene homolog) and STAT5 (signal transducer and activator of transcription 5) phosphorylation in decidualization. "
06/04/2015 - "Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), rat sarcoma/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/MEK/ERK), and phosphatidylinositol 3-kinase (PI3K) pathways. "
|2.||Caspase 3 (Caspase-3)
|3.||sorafenib (BAY 43-9006)
|4.||Mitogen-Activated Protein Kinase 8
|5.||Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
|7.||Messenger RNA (mRNA)
|8.||Interleukin-4 (Interleukin 4)
|10.||Janus Kinase 2
|1.||Heterologous Transplantation (Xenotransplantation)