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STAT Transcription Factors

A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.
Also Known As:
STAT (Signal Transducers and Activators of Transcription) Proteins; Transcription Factors, STAT
Networked: 25 relevant articles (1 outcomes, 2 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Hiller, Franziska: 1 article (09/2015)
2. Besselt, Karolin: 1 article (09/2015)
3. Deubel, Stefanie: 1 article (09/2015)
4. Brigelius-Flohé, Regina: 1 article (09/2015)
5. Kipp, Anna P: 1 article (09/2015)
6. Berton, Stefania: 1 article (08/2014)
7. Sonego, Maura: 1 article (08/2014)
8. Massarut, Samuele: 1 article (08/2014)
9. Perin, Tiziana: 1 article (08/2014)
10. Piccoli, Erica: 1 article (08/2014)

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Related Drugs and Biologics

1. Heat-Shock Proteins (Heat-Shock Protein)
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4. Transcription Factor AP-1 (Transcription Factor AP 1)
5. NF-kappa B (NF-kB)
6. Interferons
7. Janus Kinases
8. Intercellular Signaling Peptides and Proteins (Growth Factors)
9. MicroRNAs (MicroRNA)
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1. Drug Therapy (Chemotherapy)