Glycine Dehydrogenase

An oxidoreductase that catalyzes the oxidative DEAMINATION of GLYCINE to glyoxylate and AMMONIA in the presence of NAD. In BACTERIA lacking transaminating pathways the enzyme can act in the reverse direction to synthesize glycine from glyoxylate and ammonia and NADH.

Also Known As:

Dehydrogenase, Glycine

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxidoreductases Acting on CH-NH2 Group Donors
      - Amino Acid Oxidoreductases
        Glycine Dehydrogenase: 5

Experts

1.	Edwards, Ashley K: 1 article (10/2020)
2.	McKnight, Sorin M: 1 article (10/2020)
3.	Satterfield, Michael C: 1 article (10/2020)
4.	Simmons, Rebecca M: 1 article (10/2020)
5.	Wu, Guoyao: 1 article (10/2020)
6.	Feng, Bin: 1 article (08/2018)
7.	Feng, Rui: 1 article (08/2018)
8.	Liu, Hong-Qiang: 1 article (08/2018)
9.	Men, Jin-Long: 1 article (08/2018)
10.	Shao, Hua: 1 article (08/2018)

Related Diseases

1.	Neoplasms (Cancer) 02/24/2023 - "Glycine dehydrogenase (GLDC) plays an important role in the initiation and proliferation of several human cancers. " 01/01/2016 - "The metabolic enzyme, glycine dehydrogenase (GLDC), involved in glycine metabolism, is known to be involved in non-ketotic hyperglycinemia but not in cancer. "
2.	Nonketotic Hyperglycinemia 01/01/2016 - "The metabolic enzyme, glycine dehydrogenase (GLDC), involved in glycine metabolism, is known to be involved in non-ketotic hyperglycinemia but not in cancer. "
3.	Tuberculosis (Tuberculoses) 01/01/2002 - "tuberculosis, i.e., elevated glycine dehydrogenase activity. "
4.	Obesity 10/01/2020 - "Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats."
5.	Lung Neoplasms (Lung Cancer) 08/01/2018 - "Recently, it has been reported that glycine dehydrogenase (GLDC) can drive the formation of lung cancer initiating cells. " 08/01/2018 - "Serum glycine dehydrogenase is associated with increased risk of lung cancer and promotes malignant transformation by regulating DNA methyltransferases expression."

Related Drugs and Biologics

1.	Glycine (Aminoacetic Acid)
2.	Aminomethyltransferase (Glycine Synthase)
3.	Methyltransferases
4.	Enzymes
5.	DNA (Deoxyribonucleic Acid)