Proto-Oncogene Protein c-ets-1

An ets proto-oncogene protein expressed primarily in adult LYMPHOID TISSUE; BRAIN; and VASCULAR ENDOTHELIAL CELLS.

Also Known As:

Ets-1 Transcription Factor; Proto-Oncogene Proteins c-ets-1; c-ets1 Transcription Factor; Ets 1 Transcription Factor; Proto Oncogene Protein c ets 1; Proto Oncogene Protein ets 1; Proto Oncogene Proteins c ets 1; Transcription Factor, Ets-1; Transcription Factor, c-ets1; c ets 1 Protein; c ets1 Transcription Factor; c-ets-1, Proto-Oncogene Protein; c-ets-1, Proto-Oncogene Proteins; ets-1, Proto-Oncogene Protein; Proto-Oncogene Protein ets-1; c-ets-1 Protein

Networked: 94 relevant articles (0 outcomes, 14 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wernert, Nicolas: 6 articles (01/2019 - 04/2002)
2.	Hussain, Showket: 3 articles (10/2019 - 01/2019)
3.	Khan, Asiya: 3 articles (10/2019 - 01/2019)
4.	Kumar, Ramesh: 3 articles (10/2019 - 01/2019)
5.	Mehrotra, Ravi: 3 articles (10/2019 - 01/2019)
6.	Nazir, Sheeraz Un: 3 articles (10/2019 - 01/2019)
7.	Singh, Ankita: 3 articles (10/2019 - 01/2019)
8.	Tanwar, Pranay: 3 articles (10/2019 - 01/2019)
9.	Tripathi, Richa: 3 articles (10/2019 - 01/2019)
10.	Vercamer, Chantal: 3 articles (01/2019 - 06/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/05/2021 - "The transcription factor ETS-1 (E26 transformation specific sequence 1) is the key regulator for malignant tumor cell proliferation and invasion by mediating the transcription of the invasion/migration related factors, e.g. " 01/01/2021 - "An interesting question is whether the CRISPReader system can exert its anti-cancer ability against a variety of tumors by sensing the broad-spectrum transcription factor Ets-1. " 01/01/2021 - "CRISPReader System Sensing the Ets-1 Transcription Factor Can Effectively Identify Cancer Cells." 01/01/2019 - "Ets-1 transcription factor overexpression in breast cancers is associated with invasive features and is associated with a poor prognosis. " 03/01/2014 - "These results indicate that activation of the Ig Iα1 promoter by the transcription factor Ets-1 is a critical pathway and provides a novel mechanism for Ig expression in non-B cell cancers. "
2.	Carcinoma (Carcinomatosis) 11/01/1994 - "In various invasive human carcinomas, as well as in a mouse model for tumor invasion, transcripts encoding the transcription factor c-Ets1 were detected within stromal fibroblasts, whereas they were absent in epithelial tumor cells. " 08/01/2003 - "To study the expression of VEGF, KDR, MMP-1, and its transcription factor Ets-1 on the interstitial neovasculogenesis in human cervical carcinoma on molecular level, which may provide further theoretic bases on judgement of prognosis and explain interregularity between neovasculagenetic factors. " 08/01/2003 - "[Expression and significance about VEGF, KDR, MMP-1, and transcription factor Ets-1 in human cervical carcinoma]." 11/01/2004 - "Ets-1 transcription factor has been associated with tumor progression in various carcinomas, but its expression in malignant melanoma was only recently described. " 11/01/2003 - "Stromal expression of invasion-promoting, matrix-degrading proteases MMP-1 and -9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers."
3.	Glioma (Gliomas) 05/01/2005 - "In the present study, we examined whether rat C6 glioma cells express the Ets 1 transcription factor and whether inhibition of Ets 1 by a specific decoy strategy affects C6 glioma cell proliferation and mmp-9 expression. " 02/01/2009 - "We previously reported that the inactivation of the Ets 1 transcription factor by a specific decoy strategy reduces rat C6 glioma cell proliferation and mmp-9 expression. " 05/01/2005 - "Inactivation of Ets 1 transcription factor by a specific decoy strategy reduces rat C6 glioma cell proliferation and mmp-9 expression." 04/01/1999 - "These results strongly suggest that serum and bFGF control glioma invasion by inducing synthesis of Ets-1 transcription factor, which directly up-regulates expression of uPA in glioma cells. " 04/01/1999 - "In this study, we demonstrate that growth factors regulate uPA gene transcription in glioma cells by induction of Ets-1 transcription factor. "
4.	Carcinogenesis 08/30/2019 - "Our study aimed to understand the mechanism(s) in the pathogenesis of breast carcinogenesis by Ets-1 transcription factor and its downstream target gene MMP-9. " 01/01/2019 - "The present study demonstrates a crucial role of Ets-1 transcription factor which may serve as a potential biomarker for breast carcinogenesis."
5.	Meningioma (Meningiomas) 06/01/2006 - "The transcription factor Ets-1 is the main regulator of several MMPs, including MMP-2 and -9. The aim of this study was to determine the relationship between the expression of Ets-1, MMP-2 and -9 and the malignant potential of meningiomas. " 12/01/2000 - "The findings of the current study support the possibility that the Ets-1 transcription factor, through u-PA induction, may be involved in the invasive process in meningiomas." 12/01/2000 - "Immunohistochemical expression of Ets-1 transcription factor and the urokinase-type plasminogen activator is correlated with the malignant and invasive potential in meningiomas."

Related Drugs and Biologics

1.	Matrix Metalloproteinases (MMPs)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Urokinase-Type Plasminogen Activator (Urokinase)
4.	Cytokines
5.	Metalloproteases (Metalloproteinases)
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)
7.	Small Interfering RNA (siRNA)
8.	Collagenases (Collagenase)
9.	Biomarkers (Surrogate Marker)
10.	Messenger RNA (mRNA)