Proto-Oncogene Proteins c-ets

A family of transcription factors that share a unique DNA-binding domain. The name derives from viral oncogene-derived protein oncogene protein v-ets of the AVIAN ERYTHROBLASTOSIS VIRUS.

Also Known As:

Proto-Oncogene Protein ets; c-ets Protein; ets Transcription Factors; Factor, ets Transcription; Protein, c-ets Proto-Oncogene; Protein, ets Proto-Oncogene; Proto Oncogene Protein ets; Proto Oncogene Proteins c ets; Proto-Oncogene Protein, c-ets; Proto-Oncogene Protein, ets; Proto-Oncogene Proteins, c-ets; Proto-Oncogene Proteins, ets; Transcription Factor, ets; Transcription Factors, ets; c ets Protein; c ets Proto Oncogene Protein; c ets Proto Oncogene Proteins; c-ets, Proto-Oncogene Proteins; ets Proto Oncogene Protein; ets Proto Oncogene Proteins; c-ets Proto-Oncogene Protein; c-ets Proto-Oncogene Proteins; ets Proto-Oncogene Protein; ets Proto-Oncogene Proteins; ets Transcription Factor

Networked: 420 relevant articles (1 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Chinnaiyan, Arul M: 14 articles (12/2016 - 10/2005)
2.	Tomlins, Scott A: 12 articles (02/2015 - 10/2005)
3.	Janknecht, Ralf: 11 articles (01/2021 - 07/2002)
4.	Rubin, Mark A: 8 articles (02/2013 - 10/2005)
5.	Oh, Sangphil: 7 articles (01/2021 - 08/2012)
6.	Shin, Sook: 7 articles (01/2021 - 08/2012)
7.	Varambally, Sooryanarayana: 7 articles (10/2019 - 10/2005)
8.	Cao, Xuhong: 7 articles (12/2016 - 10/2005)
9.	Gutierrez-Hartmann, Arthur: 6 articles (08/2020 - 02/2003)
10.	Kovar, Heinrich: 6 articles (01/2018 - 08/2002)

Related Diseases

1.	Aneurysm (Aneurysms) 01/01/2006 - "In animal models the effects of rapamycin as an immunosuppressive agent, modulation of estrogen receptors by tamoxifen as well as gene therapy using decoy oligonucleotides binding to the transcription factor ets has already proved helpful in decreasing aneurysm expansion rates. "
2.	Neoplasms (Cancer) 05/01/2013 - "Lastly, population differences in the frequency of oncogenic erythroblast transformation-specific family of transcription factors (ETS)-related gene rearrangements were evaluated in three studies that showed that these alterations manifest themselves most commonly in tumors from men of European ancestry, but are significantly less frequent in men of African ancestry, whereas least common in men of Asian ancestry. " 04/09/2004 - "In this study, we identified a novel interaction partner of ACTR, the ETS transcription factor ER81 that is also heavily implicated in mammary tumor formation. " 11/11/2023 - "The ETS transcription factor ERG is aberrantly expressed in approximately 50% of prostate tumors due to chromosomal rearrangements such as TMPRSS2/ERG. " 08/01/2023 - "ETS transcription factor ELK3 in human cancers: An emerging therapeutic target." 01/01/2023 - "ETS transcription factor (ELK3), as a transcriptional factor, have been involved in multiple tumor development. "
3.	Prostatic Neoplasms (Prostate Cancer) 04/26/2022 - "The ETS-related gene (ERG) is proto-oncogene that is classified as a member of the ETS transcription factor family, which has been found to be consistently overexpressed in about half of the patients with clinically significant prostate cancer (PCa). " 10/18/2020 - "The rearrangement of the gene encoding the transcription factor ETS-related gene (ERG) is thought to play a key role in the development of prostate cancer. " 11/01/2019 - "SAM pointed domain-containing Ets transcription factor (SPDEF), a member of the ETS transcription factor family, has been associated with prostate cancer development; however, its role in tumour development and progression is controversial. " 01/01/2019 - "The ETS transcription factor ETV1 is frequently overexpressed in aggressive prostate cancer, which is one underlying cause of this disease. " 01/01/2019 - "Further pilot experiments demonstrated that the in vitro assays are robust for ERG, ETV1, and ETV5, three of the ETS transcription factors that are overexpressed in prostate cancer."
4.	Ewing Sarcoma (Sarcoma, Ewing) 01/01/2023 - "The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma." 01/01/2022 - "The most common and the best known representative of this group is Ewing sarcoma (ES) which is characterized by gene fusions including EWSR1 or FUS and ETS transcription factors family. " 01/01/2020 - "The genetic hallmark of classic Ewing sarcoma is a recurrent fusion between EWSR1 and FUS gene with a member of the ETS transcription factor family. " 07/07/2009 - "Ewing sarcoma translocations fuse the EWS gene with an ETS transcription factor, mainly FLI1. " 05/15/2009 - "The mechanism whereby the fusion of EWSR1 with the ETS transcription factor FLI1 contributes to malignant transformation in Ewing sarcoma remains unclear. "
5.	Carcinogenesis 01/01/2021 - "The transcription factor ETS variant 1 (ETV1) is capable of promoting prostate tumorigenesis. " 01/01/2017 - "Findings over the past decade have identified aberrant activation of the ETS transcription factor family throughout all stages of tumorigenesis. " 01/01/2017 - "This is in part due to the roles of ETS transcription factors in basic biological processes such as growth, proliferation, and differentiation, and also because of their regulatory functions that have physiological relevance in tumorigenesis, immunity, and basal cellular homoeostasis. " 11/01/2013 - "Molecular mechanisms of ETS transcription factor-mediated tumorigenesis." 08/13/2010 - "ERM is a member of the PEA3 group of the Ets transcription factor family that plays important roles in development and tumorigenesis. "

Related Drugs and Biologics

1.	Estrogen Receptors
2.	Sirolimus (Rapamycin)
3.	Tamoxifen
4.	Oligonucleotides
5.	Immunosuppressive Agents (Immunosuppressants)
6.	Androgens
7.	Proteins (Proteins, Gene)
8.	Transcription Factors (Transcription Factor)
9.	Serine Proteases (Serine Protease)
10.	Androgen Receptors (Androgen Receptor)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Therapeutics
3.	Heterologous Transplantation (Xenotransplantation)
4.	Punctures
5.	Ligation