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Protoporphyrinogen Oxidase (Protox)

A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the HEME and CHLOROPHYLL pathways in plants, and is the molecular target of diphenyl ether-type herbicides. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of protoporphyrinogen oxidase.
Also Known As:
Protox; Oxidase, Protoporphyrinogen; Protoporphyrinogen Dehydrogenase; Protoporphyrinogen IX Oxidase; Protoporphyrinogenase; Dehydrogenase, Protoporphyrinogen; Oxidase, Protoporphyrinogen IX
Networked: 94 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Frank, J: 5 articles (02/2012 - 01/2001)
2. Frank, Jorge: 4 articles (03/2015 - 07/2006)
3. Poblete-Gutiérrez, Pamela: 4 articles (03/2015 - 07/2006)
4. Schneider-Yin, Xiaoye: 3 articles (03/2015 - 08/2006)
5. Poblete-Gutiérrez, P: 3 articles (02/2012 - 01/2006)
6. Meissner, Peter N: 3 articles (05/2006 - 08/2003)
7. Christiano, A M: 3 articles (01/2006 - 01/2001)
8. Deybach, Jean-Charles: 3 articles (07/2004 - 02/2002)
9. Went, Philip: 2 articles (03/2015 - 09/2010)
10. van Geel, Michel: 2 articles (03/2015 - 11/2011)

Related Diseases

1. Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency)
2. Acute Intermittent Porphyria (Porphyria, Acute)
3. Porphyrias
4. Hepatic Porphyrias (Hepatic Porphyria)
5. Hereditary Coproporphyria (Coproporphyrinogen Oxidase Deficiency)

Related Drugs and Biologics

1. Heme (Haem)
2. Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)
3. Enzymes
4. Ferrochelatase (Heme Synthetase)
5. Coproporphyrinogen Oxidase (Coproporphyrinogen III Oxidases)
6. Uroporphyrinogen Decarboxylase (Uroporphyrinogen III Decarboxylase)
7. Complementary DNA (cDNA)
8. Porphyrins
9. protoporphyrin IX
10. protoporphyrinogen (protoporphyrinogen IX)

Related Therapies and Procedures

1. Photochemotherapy (Photodynamic Therapy)