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Cyclin-Dependent Kinase Inhibitor p27

A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.
Also Known As:
CDK Inhibitor p27; CDKN1B Protein; CDKN4 Protein; Cyclin-Dependent Kinase Inhibitor 1B; p27 CDK Inhibitor; p27 Kip1 Protein; p27Kip1 Protein; CDK Inhibitor, p27; Cyclin Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor p27; Kip1 Protein, p27; p27, CDK Inhibitor
Networked: 455 relevant articles (4 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Supriatno,: 6 articles (01/2011 - 10/2002)
2. Pellegata, Natalia S: 5 articles (01/2015 - 07/2007)
3. Cleveland, John L: 5 articles (09/2014 - 04/2003)
4. Viglietto, Giuseppe: 5 articles (03/2012 - 10/2002)
5. Fusco, Alfredo: 5 articles (09/2007 - 10/2002)
6. Harada, Koji: 5 articles (09/2005 - 10/2002)
7. Sato, Mitsunobu: 5 articles (09/2005 - 10/2002)
8. Yoshida, Hideo: 5 articles (09/2005 - 10/2002)
9. Nakayama, Keiko: 4 articles (01/2017 - 08/2005)
10. Korbonits, Márta: 4 articles (03/2013 - 01/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Carcinoma (Carcinomatosis)
3. Carcinogenesis
4. Adenocarcinoma of Lung
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Gemcitabine
2. N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamide
3. Cyclin-Dependent Kinases (cdk Proteins)
4. Proteins (Proteins, Gene)
5. Cyclins
6. MicroRNAs (MicroRNA)
7. Biomarkers (Surrogate Marker)
8. Cyclin D1
9. Messenger RNA (mRNA)
10. S-Phase Kinase-Associated Proteins (Skp1 Protein)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Filtering Surgery
4. Stents
5. Prostatectomy (Retropubic Prostatectomy)