A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.
Also Known As:
CDK Inhibitor p27; CDKN1B Protein; CDKN4 Protein; Cyclin-Dependent Kinase Inhibitor 1B; p27 CDK Inhibitor; p27 Kip1 Protein; p27Kip1 Protein; CDK Inhibitor, p27; Cyclin Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor p27; Kip1 Protein, p27; p27, CDK Inhibitor