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Bone Fractures (Bone Fracture)

Subscribe to New Research on Bone Fractures

Breaks in bones.

Also Known As:

Bone Fracture; Broken Bones; Fracture, Bone; Bone, Broken; Broken Bone; Fractures, Bone; Bones, Broken

Networked: 1102 relevant articles (50 outcomes, 132 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteoporosis
2.	Breast Neoplasms (Breast Cancer)
3.	Wounds and Injuries (Trauma)
4.	Hemorrhage
5.	Pain (Aches)

Experts

1.	Kawaguchi, Hiroshi: 4 articles (11/2009 - 03/2007)
2.	O'Connor, J Patrick: 4 articles (03/2009 - 06/2002)
3.	Kubodera, Noboru: 3 articles (09/2009 - 07/2006)
4.	Hatakeyama, Susumi: 3 articles (09/2009 - 07/2006)
5.	Ohta, Hiroaki: 3 articles (05/2009 - 06/2005)
6.	Nakamura, Kozo: 3 articles (01/2009 - 03/2007)
7.	Kamekura, Satoru: 3 articles (01/2009 - 03/2007)
8.	Gallagher, E John: 3 articles (07/2008 - 06/2006)
9.	Bérard, Anick: 3 articles (07/2008 - 06/2006)
10.	Goldhirsch, Aron: 3 articles (04/2008 - 06/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bone Fractures:

1.	Tamoxifen FDA LinkGeneric 10/01/2007 - "Despite an apparent impact of tamoxifen on bone mineral density, the few available studies of tamoxifen and bone fractures appear to suggest no protective effect but an increase in fracture incidence. " 08/01/1998 - "OBJECTIVES: To evaluate the association between tamoxifen (TAM) treatment and rate of bone fractures in older, nursing home residents. " 08/01/1998 - "Effect of tamoxifen on bone fractures in older nursing home residents." 12/01/2001 - "The Breast Cancer Prevention Trial (BCPT, P-1) demonstrated that tamoxifen can reduce the incidence of both invasive and noninvasive breast cancer as well as of bone fractures in women at increased risk. " 03/01/1994 - "The Breast Cancer Prevention Trial (BCPT), under the auspices of the National Surgical Adjuvant Breast and Bowel Project (NSABBP), will evaluate the effect of tamoxifen in reducing the incidence of invasive breast cancer, breast cancer mortality, cardiovascular mortality, and bone fractures. " Order ALL the reference details at left...
2.	Estrogens (Estrogen)FDA Link 04/01/2009 - "The findings, assessed on the basis of biochemical, bone mineral density, biomechanical, and histopathological parameters, showed that ICA has a definite antiosteoporotic effect, similar to estrogen, especially effective for prevention bone fracture induced by estrogen deficiency." 05/01/2009 - "There is the evidence that estrogens prevent bone fractures in not only osteoporotic women but also healthy women. " 05/01/1953 - "[Diet, estrogens and bone fractures.]" 09/01/1995 - "Although the definitive answer is not yet available, recent epidemiologic data suggest no reduction in protection against CVD and bone fracture with the addition of progestin, which is referred to as hormone replacement therapy, as opposed to using estrogen alone. " 05/01/2007 - "Data suggest an attenuation of the potential cardiovascular benefit of estrogen therapy in this situation, yet no better protection against bone fractures and an increase in the risk for breast cancer when both estrogen and progestogen are used." Order ALL the reference details at left...
3.	Raloxifene (Evista)FDA Link 05/01/2009 - "Notably, the available evidence for raloxifene suggests that the efficacy of raloxifene in preventing bone fractures has not only to do with bone mineral density but also to do with bone quality." 10/01/2008 - "Notably, the available evidence for raloxifene suggests that the efficacy of raloxifene in preventing bone fractures has not only to do with bone mineral density but also to do with bone quality." 05/01/2009 - "Thus, this review has drawn mainly on the results of the MORE study to explore the efficacy of raloxifene in inhibiting bone metabolism, increasing bone mineral density effects, and preventing bone fractures. " 10/01/2008 - "Thus, this review has drawn mainly on the results of the MORE study to explore the efficacy of raloxifene in inhibiting bone metabolism, increasing bone mineral density effects, and preventing bone fractures. " 04/01/1998 - "In older postmenopausal women with existing bone fractures, raloxifene 60 or 120 mg/day for 1 year produced modest increases in bone mineral density. " Order ALL the reference details at left...
4.	Aromatase InhibitorsIBA 02/01/2006 - "Tolerability is improved with aromatase inhibitors, the major concern with the use of aromatase inhibitors being the development of osteoporosis and bone fractures. " 01/01/2009 - "Results from directly comparative trials indicating the efficacy, tolerability and bone fracture risk of exemestane relative to third-generation aromatase inhibitors and other agents in both early-stage and advanced disease, as well as the optimal sequence of endocrine therapies, are awaited with interest. " 01/01/2008 - "Like other aromatase inhibitors, its most important adverse effect was an increased risk of bone fractures, which for anastrozole was restricted to the treatment period. " 06/01/2007 - "Women taking aromatase inhibitors were significantly more likely to have bone fractures than those on tamoxifen (rate ratio = 2.42). " 01/01/2008 - "Fulvestrant is as effective as aromatase inhibitors in the treatment of advanced breast cancer and does not cause bone fractures. " Order ALL the reference details at left...
5.	Selective Estrogen Receptor Modulators (SERM)IBA 06/01/2006 - "Before interpretation of S-NTX, we should estimate glomerular filtration rate by using Cockcroft-Gault formula, especially in elderly patients with low body mass index such as rheumatic patients, whose S-Cr-is in normal ranges Both markers are very useful for estimating the risk of bone fracture and for monitoring therapeutic effects of anti-resorptive agents such as bisphosphonate or selective estrogen receptor modulator." 01/01/2006 - "On the basis of the findings that a selective estrogen receptor modulator, raloxifene, showed a protective effect of bone fracture far more potent than its BMD-increasing effect, the hypothesis that bone marker indicates fracture risk independent of BMD has been raised and established." 09/01/2005 - "Evidence indicates raloxifene (RLX), a selective estrogen receptor modulator, is effective for a protection of bone fracture without increasing of breast cancer and endometrial cancer. " 04/01/2005 - "Evidence indicates that estrogen and raloxifene hydrochloride, a selective estrogen receptor modulator, prevent bone loss and reduce the risk of bone fractures in postmenopausal women. " 01/01/2000 - "The Study of Tamoxifen And Raloxifene (STAR), presently ongoing, will address the questions of breast cancer prevention, risk of endometrial cancer, the incidence of bone fractures, and coronary artery disease in women treated with these SERMs." Order ALL the reference details at left...
6.	DiphosphonatesIBA 05/01/2009 - "Although further studies relating to the mechanism for possible impaired bone strength in these patients will be needed, bisphosphonates may be beneficial treatment for prevention of bone fractures in patients with severe risk for fractures, such as post-menopausal women." 07/01/2010 - "The incidence of bone fractures during AI therapy is lower in Japan, and the addition of bisphosphonates enhances bone health. " 11/01/2007 - "The treatment of osteoporotic women with bisphosphonates significantly reduces the incidence of bone fractures to a degree greater than can be explained by an increase in bone mineral density. " 10/01/2004 - "Bisphosphonates are drugs that decrease the incidence of bone fractures, but their use in juvenile patients is still controversial because of their possible side effects on the growing skeleton. " 07/27/2008 - "Bisphosphonates and bone fractures in long-term kidney transplant recipients." Order ALL the reference details at left...
7.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/01/2001 - "Bisphosphonate therapy, therefore, appears to be an effective, well-tolerated means of reducing the risk of bone fractures among patients treated with corticosteroids." 10/01/2009 - "METHODS: We conducted a meta-analysis of published studies of patients with long-bone fractures who were randomly assigned to groups receiving corticosteroids or standard treatment for the prevention of FES (1966-2006). " 10/01/2009 - "Our objective was to determine the effect of corticosteroids in preventing FES in patients with long-bone fractures. " 03/01/2004 - "Prevention of posttraumatic hypoxaemia in isolated lower limb long bone fractures with a minimal prophylactic dose of corticosteroids." 02/01/1998 - "The author demonstrates on a group of 292 patients (207 women, 85 men) treated on account of various diseases with corticoids laboratory parameters and bone density and records of bone fractures. " Order ALL the reference details at left...
8.	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 01/01/1996 - "The most effective drug in osteoporosis with increase bone turnover seems to be calcitonin, which is especially effective in treatment of senile osteoporosis (type II) and in all cases complicated by bone fractures." 03/01/2004 - "CONCLUSION: The results of this study show that the chronic lack of calcitonin in total thyroidectomized patients may play a role in increased bone degradation and osteopenia with a higher risk of bone fracture." 09/01/1992 - "The effect of calcitonin therapy by injection or nasal spray on the incidence of bone fractures was studied in patients with osteogenesis imperfecta. " 09/01/1992 - "In contrast to injection of calcitonin, intranasal administration of calcitonin twice a week for 2 weeks, followed by 2 weeks of no therapy, was simple and seemed beneficial for decreasing bone fractures in patients with osteogenesis imperfecta." 01/01/1995 - "The aim of this study was to evaluate the effects of calcitonin (CT) treatment on bone pain, osteoporosis, bone fractures and blood chemistry in thalassemic patients. " Order ALL the reference details at left...
9.	Vitamin D FDA LinkGeneric 04/01/2004 - "It is generally accepted that supplemental Ca and/or vitamin D is effective in reducing the incidence of bone fractures; this is supported by numerous randomised controlled trials and meta-analyses. " 03/01/2010 - "Clinical studies have suggested a possible association of low serum vitamin D levels in patients with bone fractures. " 04/01/2010 - "In this context, any strategy preventing the occurrence of bone fractures, such as vitamin D supplementation, is welcome. " 04/01/2010 - "Vitamin D and bone fracture mechanisms: what about the non-bone 'D'efense?" 03/01/2010 - "This, coupled with a high prevalence of fractures and increases in associated disability and mortality, begs the question, is there evidence to support a role for therapeutic drug monitoring of vitamin D levels to prevent bone fractures? " Order ALL the reference details at left...
10.	Morphine (MS Contin)FDA LinkGeneric 03/01/2007 - "STUDY OBJECTIVE: We compare the efficacy of intranasal fentanyl versus intravenous morphine in a pediatric population presenting to an emergency department (ED) with acute long-bone fractures. " 03/01/2007 - "A convenience sample of children aged 7 to 15 years with clinically deformed closed long-bone fractures was included to receive either active intravenous morphine (10 mg/mL) and intranasal placebo or active intranasal concentrated fentanyl (150 microg/mL) and intravenous placebo. " 01/01/2009 - "CONCLUSION: We conclude that morphine sulphate with addition of small doses of ketamine provide adequate pain relief in patients with bone fractures, with an increase in systolic blood pressure, but without significant side effects." 04/01/2008 - "Intranasal fentanyl and intravenous morphine did not differ for pain relief in children with closed long-bone fractures." 03/01/2008 - "Morphine and ketoprofen administration provided the same effect on behavioral testing on postoperative days 1 and 2. CONCLUSION: This mouse model seems to be a reliable and reproducible tool to investigate the effect of closed bone fracture on several parameters, such as pain, remodeling, and recovery. " Order ALL the reference details at left...

Therapies and Procedures

1.	Debridement 06/01/2007 - "Injured Coalition combatants received high-level damage control orthopaedic care and initial debridements, with external fixation as the single most common means of long-bone fracture stabilization. " 07/20/2009 - "Thorough debridements and primary treatments to associated tendon ruptures or bone fractures were performed on emergency. " 08/01/2007 - "AIMS: To determine whether a delay of greater than 6h from injury to initial surgical debridement and the timing of antibiotic administration affect infection rates in open long-bone fractures. " 03/01/2004 - "OBJECTIVES: To determine whether a time delay of greater than 6 h from injury to surgical debridement affected the infection rate in open long-bone fractures in a typical district general hospital in the UK. " 01/01/1990 - "Adequate debridement is crucial in treating osteomyelitis complicating established long bone fractures and nonunions. " Order ALL the reference details at left...
2.	Decompression 02/01/2010 - "Conclusion Decreasing the time of compression, appropriate incision and decompression, and hemodialysis help improve the result of limb salvage in hyperpotassemia patients with bone fracture caused by earthquake." 08/01/1994 - "In addition, a reduction of the "antigenic load" by control of hemorrhage, radical wound debridement, decompression, and fixation of long bone fractures appears to be effective in reducing the occurrence of MODS. " 01/01/1994 - "In addition, a reduction of the antigenic load by control of hemorrhage, radical wound debridement, decompression, and fixation of long bone fractures appears to be effective in reducing the occurrence of MODS. " Order ALL the reference details at left...
3.	Hormone Replacement Therapy (Therapy, Hormone Replacement) 01/01/2008 - "AIMS: To investigate the effect of duration, how recently it has been used, and age at start of hormone replacement therapy (HRT) and the risk of bone fracture. " 02/01/2006 - "There have been several clinical studies of hormone replacement therapy (HRT) in post-menopausal women to examine whether HRT has beneficial effects on the cardiovascular system, bone fractures, lipid metabolism, and Alzheimer's disease. " 09/17/2001 - "CONCLUSION: Despite their risk of early menopause, cardiovascular disease and bone fracture, few women undergoing haemodialysis were offered hormone replacement therapy. " 08/01/1998 - "MEASUREMENTS: Measurements included age, ethnicity, TAM treatment, hormone replacement therapy, vision impairment, any bone fractures, and, specifically, hip fractures. " 09/01/1995 - "A woman's potential risks associated with ERT or hormone replacement therapy must be weighed against her lifetime risks of developing CVD, stroke, and bone fracture. " Order ALL the reference details at left...
4.	Transplants (Transplant) 01/01/2002 - "Bone defect is the most common cause of non-union of forearm bone fractures resulting from missile injury and early slivered cancellous bone graft is effective in the treatment of non-union." 01/01/2006 - "Future trials in the elderly should focus on such endpoints as PTDM, post-transplant neoplasia, cardiovascular events and bone fracture events in order to identify the safest regimens that provide the optimal control of rejection while limiting the morbidity from these secondary events." 12/01/2009 - "Combining autologous bone graft and recombinant human bone morphogenetic protein-7 (BMP-7) to treat long-bone fracture aseptic atrophic nonunions theoretically could promote bone healing at higher rates than each of these grafting agents separately. " 10/01/2008 - "Donor-site complications included partial loss of the split thickness skin graft (25%) and 1 radial bone fracture. " 02/01/2008 - "This resulted in a two-thirds reduction in long bone fractures (P < .01), with fewer fractures per mouse (median 1, range 0-2 in mice that received transplants vs median 3, range 1-5 in mice that did not receive transplants by 12 weeks, P < .01). " Order ALL the reference details at left...
5.	Analgesia 03/01/2008 - "Impact of analgesia on bone fracture healing." 05/01/2003 - "We studied the effectiveness of this technique for analgesia after a femoral bone fracture in pre-hospital care. " 09/01/2002 - "OBJECTIVE: Ethnic and racial differences in the provision of emergency department (ED) analgesia for long-bone fractures have recently been reported in two large cities. " 05/01/2000 - "For long bone fractures, in 1993, 53% of patients received intramuscular narcotic analgesia compared with 5% in 1997. " 05/01/2010 - "PURPOSE: This study evaluated the effects of pain assessment at triage on analgesia provision to pediatric patients with closed long-bone fractures in the emergency department (ED). " Order ALL the reference details at left...

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