Retinoblastoma-Like Protein p130

A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.

Also Known As:

RBL2 Protein; Retinoblastoma Like Protein p130; Retinoblastoma Like Protein 2; p130, Retinoblastoma-Like Protein; Retinoblastoma-Like Protein 2

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Kim, Dong-Wook: 1 article (11/2020)
2.	Kim, Kee-Beom: 1 article (11/2020)
3.	Kim, Youngchul: 1 article (11/2020)
4.	Park, Kwon-Sik: 1 article (11/2020)
5.	Rivard, Christopher J: 1 article (11/2020)
6.	Chen, Hao: 1 article (01/2018)
7.	Ge, Ouyang: 1 article (01/2018)
8.	Gu, Jiangning: 1 article (01/2018)
9.	Li, Ying: 1 article (01/2018)
10.	Peng, Chenghong: 1 article (01/2018)

Related Diseases

1.	Neoplasms (Cancer) 11/15/2020 - "Notably, Fgfr1 knockout suppressed tumor development in a mouse model lacking the retinoblastoma-like protein 2 (Rbl2) tumor suppressor gene but did not affect a model with wild-type Rbl2. " 01/01/2018 - "Our results indicate that miR-17-5p was up-regulated in pancreatic adenocarcinoma and directly targeted the retinoblastoma-like protein 2 (RBL2), a tumor suppressor belonging to the Rb family. " 07/31/2014 - "Consistent with earlier work, HPV16 E7 can bind to the retinoblastoma tumor suppressor (RB) family member p130 (RBL2) protein and promote its proteasome-mediated destruction thereby disrupting the DREAM complex and can prevent exit from the cell cycle into quiescence. "
2.	Retinoblastoma (Glioblastoma, Retinal) 07/31/2014 - "Consistent with earlier work, HPV16 E7 can bind to the retinoblastoma tumor suppressor (RB) family member p130 (RBL2) protein and promote its proteasome-mediated destruction thereby disrupting the DREAM complex and can prevent exit from the cell cycle into quiescence. "
3.	Adenocarcinoma 01/01/2018 - "Our results indicate that miR-17-5p was up-regulated in pancreatic adenocarcinoma and directly targeted the retinoblastoma-like protein 2 (RBL2), a tumor suppressor belonging to the Rb family. "

Related Drugs and Biologics

1.	Proteasome Endopeptidase Complex (Proteasome)