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E2F1 Transcription Factor

An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A and activates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F1 is involved in DNA REPAIR and APOPTOSIS.
Also Known As:
E2F Transcription Factor 1 Protein; E2F-1 Transcription Factor; Retinoblastoma Binding Protein 3; Retinoblastoma-Associated Protein 1; Transcription Factor E2F-1; Transcription Factor E2F1; Retinoblastoma Associated Protein 1; Transcription Factor E2F 1; Transcription Factor, E2F-1; Transcription Factor, E2F1
Networked: 184 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Pützer, Brigitte M: 8 articles (07/2019 - 04/2006)
2. Ginsberg, Doron: 6 articles (05/2021 - 01/2003)
3. Johnson, David G: 5 articles (01/2020 - 03/2002)
4. Hunt, Kelly K: 4 articles (03/2010 - 04/2003)
5. Swisher, Stephen G: 4 articles (03/2010 - 04/2003)
6. Li, Zunling: 3 articles (11/2017 - 04/2014)
7. Jordan-Sciutto, Kelly L: 3 articles (03/2015 - 03/2002)
8. Knoll, Susanne: 3 articles (12/2014 - 03/2010)
9. Steder, Marc: 3 articles (11/2010 - 01/2010)
10. Engelmann, David: 3 articles (08/2010 - 01/2010)

Related Diseases

1. Hepatocellular Carcinoma (Hepatoma)
2. Varicocele
3. Hypoxia (Hypoxemia)
07/31/2013 - "In this study, we sought to investigate the expression of the transcription factor E2F1 in chicken pulmonary arterial smooth muscle cells upon hypoxia exposure, as well as the role that E2F1 played in the regulation of cell proliferation. "
11/01/2011 - "The present study determined that silencing the NHE1 gene significantly inhibited the hypoxia-induced proliferation, hypertrophy, and migration of human PASMCs via repression of the nuclear transcription factor E2F1. "
01/01/2019 - "In the present study, we show that human HIGD2A and mouse Higd2a gene expressions are regulated by hypoxia, glucose, and the cell cycle-related transcription factor E2F1. "
05/01/2009 - "In addition, regulated expression of core protein in HepG2 or Huh7 cells was found to induce expression and activation of the transcription factor E2F1 and apoptosis signal-regulating kinase 1 (ASK1), activation of c-jun-N-terminal kinase (JNK) and p38, and extracellular-regulated kinase (ERK), and transcription factors activator protein 1 (AP-1), activating transcription factor 2 (ATF-2), cyclic adenosine monophosphate response element binding (CREB), E2F1, hypoxia inducing factor 1 alpha (HIF-1alpha), and specificity protein 1. Furthermore, data obtained from inhibitor experiments revealed the importance of E2F1 and ASK1 in the modulation of core-induced activation of JNK and p38 pathways and suggested an essential role for JNK, p38, and ERK pathways in the regulation of core-induced production of TGF-beta2 and VEGF proteins. "
4. Neoplasms (Cancer)
5. Prostatic Neoplasms (Prostate Cancer)

Related Drugs and Biologics

1. Antioxidants
2. Sorafenib (BAY 43-9006)
3. Transcription Factors (Transcription Factor)
4. Long Noncoding RNA
5. Catenins
6. Glucose (Dextrose)
7. Proteins (Proteins, Gene)
8. Retinoblastoma Protein
9. Phosphotransferases (Kinase)
10. Cyclin D1