|1.||Pützer, Brigitte M: 7 articles (12/2014 - 04/2006)|
|2.||Ginsberg, Doron: 4 articles (01/2013 - 01/2003)|
|3.||Swisher, Stephen G: 4 articles (03/2010 - 04/2003)|
|4.||Hunt, Kelly K: 4 articles (03/2010 - 04/2003)|
|5.||Johnson, David G: 4 articles (11/2005 - 03/2002)|
|6.||Knoll, Susanne: 3 articles (12/2014 - 03/2010)|
|7.||Steder, Marc: 3 articles (11/2010 - 01/2010)|
|8.||Engelmann, David: 3 articles (08/2010 - 01/2010)|
|9.||Vorburger, Stephan A: 3 articles (11/2005 - 04/2003)|
|10.||Kittas, Christos: 3 articles (09/2004 - 10/2002)|
|2.||Hepatocellular Carcinoma (Hepatoma)
01/01/2013 - "In this study, we sought to investigate the expression of the transcription factor E2F1 in chicken pulmonary arterial smooth muscle cells upon hypoxia exposure, as well as the role that E2F1 played in the regulation of cell proliferation. "
11/01/2011 - "The present study determined that silencing the NHE1 gene significantly inhibited the hypoxia-induced proliferation, hypertrophy, and migration of human PASMCs via repression of the nuclear transcription factor E2F1. "
05/01/2009 - "In addition, regulated expression of core protein in HepG2 or Huh7 cells was found to induce expression and activation of the transcription factor E2F1 and apoptosis signal-regulating kinase 1 (ASK1), activation of c-jun-N-terminal kinase (JNK) and p38, and extracellular-regulated kinase (ERK), and transcription factors activator protein 1 (AP-1), activating transcription factor 2 (ATF-2), cyclic adenosine monophosphate response element binding (CREB), E2F1, hypoxia inducing factor 1 alpha (HIF-1alpha), and specificity protein 1. Furthermore, data obtained from inhibitor experiments revealed the importance of E2F1 and ASK1 in the modulation of core-induced activation of JNK and p38 pathways and suggested an essential role for JNK, p38, and ERK pathways in the regulation of core-induced production of TGF-beta2 and VEGF proteins. "
06/01/2002 - "Previous studies have demonstrated both oncogenic and tumor suppressive properties for the E2F1 transcription factor. "
08/22/2013 - "The transcription factor E2F1 has pivotal roles in both cell proliferation and cell death, and is an important molecular target in cancer. "
08/16/2013 - "The E2F1 transcription factor is active in many types of solid tumors and can function as either an oncogene or tumor suppressor in vivo. "
01/01/2013 - "The pivotal transcription factor E2F1 which can induce both proliferation and cell death, is a critical downstream target of the tumor suppressor, RB. "
01/01/2013 - "Transcription factor E2F1 exerts effects on many types of cancers. "
11/01/2007 - "In this study, we show that the E2F1 transcription factor, which is implicated in carcinoma invasiveness, upregulates the expression of PACE4. "
10/01/2013 - "We report that the transcription factor E2F1 binds only to the E2F1 distal site of the p53 promoter in the human papillomavirus positive carcinoma HeLa cell line. "
07/01/2004 - "Distinct expression patterns of the transcription factor E2F-1 in relation to tumour growth parameters in common human carcinomas."
11/01/1997 - "Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53."
11/01/2005 - "Overexpression of the transcription factor E2F-1 induces apoptosis in a variety of carcinoma cells and inactivates murine double minute protein 2, a factor associated with poor prognosis in soft tissue sarcomas. "
|1.||sorafenib (BAY 43-9006)
|2.||Transcription Factors (Transcription Factor)
|4.||Proteins (Proteins, Gene)
|6.||DNA (Deoxyribonucleic Acid)
|7.||Cyclin-Dependent Kinase 4
|10.||Small Interfering RNA (siRNA)