E2F Transcription Factors

A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.

Also Known As:

Networked: 483 relevant articles (2 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lees, Jacqueline A: 6 articles (01/2010 - 12/2002)
2.	Wang, Lin: 5 articles (05/2021 - 05/2004)
3.	Andrechek, Eran R: 5 articles (01/2019 - 08/2007)
4.	Iwanaga, Ritsuko: 5 articles (01/2018 - 01/2009)
5.	Ohtani, Kiyoshi: 5 articles (01/2018 - 01/2009)
6.	Ozono, Eiko: 5 articles (01/2018 - 01/2009)
7.	Du, Wei: 4 articles (03/2022 - 10/2017)
8.	Bradford, Andrew P: 4 articles (01/2018 - 07/2014)
9.	Kurayoshi, Kenta: 4 articles (01/2018 - 07/2014)
10.	Lees, J A: 4 articles (01/2009 - 02/2001)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Recent studies reported that E2F transcription factor 2 (E2F2) plays a significant role in tumor progression. " 01/01/2021 - "Numerous studies on the E2F transcription factors have led to increasing insights that E2Fs could be an important driver of the formation and progression of many human cancers. " 12/01/2015 - "In the present study, miR-214 was observed to suppress tumor proliferation by directly targeting E2F transcription factor 3 (E2F3) in HCC cells. " 11/15/2012 - "Although the canonical pathway that links this tumor suppressor to human cancers details its interaction with the E2F transcription factors and cell-cycle progression, recent studies have shown an essential role for RB-1 in the suppression of glycolytic and glutaminolytic metabolism. " 11/03/2005 - "During recent studies utilizing MDM2 inhibitors, we noted that E2F transcription factor 1 (E2F1) was down regulated upon inhibition of MDM2, regardless of the p53 status of the cancer. "
2.	Cardiotoxicity 01/01/2018 - "The aim of the present study was to clarify the specific role of E2F transcription factor 1 (E2F1) in regulating autophagy and apoptosis in DOX-induced cardiotoxicity as well as the protective effects of RSV. "
3.	Retinoblastoma (Glioblastoma, Retinal) 01/01/2023 - "The plant RETINOBLASTOMA-RELATED (RBR) has been implicated in stem cell maintenance, presumably by forming repressor complexes with E2F transcription factors. " 01/01/2020 - "Cell cycle entry and quiescence are regulated by the E2F transcription factors in association with RETINOBLASTOMA-RELATED (RBR). " 01/01/2018 - "The mechanism involving hyper-phosphorylation of retinoblastoma (Rb) and activation of transcription factor E2F is linked to the R-point passage. " 08/23/2013 - "Selective interaction of MAGE-A11 with retinoblastoma family members suggested the regulation of E2F transcription factors. " 02/18/2011 - "A critical substrate of CDKs is the product of the retinoblastoma tumor suppressor gene, pRb, which inhibits G(1)-S phase cell cycle progression by binding and repressing E2F transcription factors. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "This study aimed to determine the role of RPL5/E2F transcription factor 1 (E2F1) in breast cancer. " 12/01/2023 - "E2F transcription factor 3 (E2F3) is overexpressed in breast cancer tissues, and promotes proliferation of breast cancer cells. " 06/01/2018 - "Expression patterns of E2F transcription factors and their potential prognostic roles in breast cancer." 02/01/2018 - "Breast cancer 1 (BRCA1) and E2F transcription factor 1 (E2F1) are related to metabolism and cell cycle regulation. " 01/01/2018 - "Expressions and prognostic values of the E2F transcription factors in human breast carcinoma."
5.	Neoplasm Metastasis (Metastasis) 03/01/2022 - "E2F transcription factor 1 (E2F1) is a key mediator of cell cycle progression that participates in the progression, metastasis, and chemoresistance of CRC. " 01/01/2019 - "In prior work we demonstrated that loss of E2F transcription factors inhibits metastasis. " 01/01/2016 - "More recently, studies have highlighted additional roles of this pathway, especially E2F transcription factors themselves, in tumor progression, angiogenesis and metastasis. " 01/01/2021 - "Cell cycle activator E2F transcription factor 2 (E2F2) play a key role in tumor development and metastasis. " 01/01/2020 - "Regulation of E2F Transcription Factor 3 by microRNA-152 Modulates Gastric Cancer Invasion and Metastasis."

Related Drugs and Biologics

1.	Cyclin D1
2.	Proteins (Proteins, Gene)
3.	Transcription Factors (Transcription Factor)
4.	MicroRNAs (MicroRNA)
5.	Phosphotransferases (Kinase)
6.	DNA (Deoxyribonucleic Acid)
7.	Long Noncoding RNA
8.	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)
9.	Cyclins
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Drug Therapy (Chemotherapy)
4.	Filtering Surgery
5.	Photochemotherapy (Photodynamic Therapy)