R-SNARE Proteins (Vesicle-Associated Membrane Protein)

SNARE proteins where the central amino acid residue of the SNARE motif is an ARGININE. They are classified separately from the Q-SNARE PROTEINS where the central amino acid residue of the SNARE motif is a GLUTAMINE. This subfamily contains the vesicle associated membrane proteins (VAMPs) based on similarity to the prototype for the R-SNAREs, VAMP2 (synaptobrevin 2).

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Networked: 147 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rossetto, Ornella: 3 articles (04/2022 - 05/2003)
2.	Binz, Thomas: 2 articles (04/2022 - 06/2005)
3.	Montecucco, Cesare: 2 articles (04/2022 - 05/2003)
4.	Ratnaparkhi, Anuradha: 2 articles (01/2022 - 06/2008)
5.	Gaisano, Herbert Y: 2 articles (10/2021 - 10/2017)
6.	Jaarsma, Dick: 2 articles (10/2021 - 09/2007)
7.	Tripathi, Priyanka: 2 articles (10/2021 - 01/2020)
8.	Yamoah, Alfred: 2 articles (10/2021 - 01/2020)
9.	Campos-Acevedo, Luis Daniel: 2 articles (06/2020 - 12/2016)
10.	Martínez-de-Villarreal, Laura Elia: 2 articles (06/2020 - 12/2016)

Related Diseases

1.	Botulism 01/01/2023 - "Using electrophysiology and immunohistochemistry, we demonstrate that TeNT cleaves its substrate vesicle-associated membrane protein within facial neuromuscular junctions and causes a botulism-like paralysis overshadowing tetanus spasticity. " 07/01/1998 - "The 18.7-kDa thioredoxin-synaptobrevin protein, designated as TSB-51, is intended for use in a cell-free assay to test potential inhibitors of BoNT/B-mediated proteolysis of synaptobrevin with the ultimate aim of developing clinically effective therapeutic agents to counteract botulism. " 11/01/2016 - "Immunohistochemistry was used to compare the expression of synaptosomal-associated protein-25, synaptobrevin (Syb) and syntaxin within CCG neurons, and of Syb in enteric neurons, from horses with EGS, horses with botulism and control horses. " 08/01/2014 - "Serotype D botulinum toxin (BoNT) complex (TC), a causative agent of foodborne botulism in animals, traverses the gastrointestinal tract and circulation, eventually becoming localized in neuromuscular junctions, where the serotype D BoNT cleaves SNARE substrate synaptobrevin II involved in neurotransmitter release. " 06/01/2004 - "This metallo-protease neurotoxin cleaves synaptobrevin, a protein, which is crucial to neurotransmission, resulting in the muscle paralysis, which characterizes botulism. "
2.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/19/2022 - "Mutations in the gene encoding vesicle-associated membrane protein B (VAPB) cause a familial form of amyotrophic lateral sclerosis (ALS). " 08/07/2014 - "Mutations in the gene encoding vesicle-associated membrane protein (VAPB) cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. " 10/19/2022 - "We report that expression of a gene equivalent to an amyotrophic lateral sclerosis (ALS)-causing variant of vesicle-associated membrane protein B (VAPB) in fly neurons decouples mitochondrial ATP production from neuronal activity. " 01/01/2020 - "A point mutation (P56S) in the gene-encoding vesicle-associated membrane-protein-associated protein B (VAPB) leads to an autosomal-dominant form of amyotrophic lateral sclerosis (ALS), classified as ALS-8. " 12/01/2018 - "Recently, vesicle-associated membrane protein-associated protein B (VAPB), which is associated with the familial form of amyotrophic lateral sclerosis, has been shown to regulate autophagy. "
3.	Motor Neuron Disease (Primary Lateral Sclerosis) 09/05/2007 - "Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates." 08/01/2019 - "Amyotrophic lateral sclerosis type 8 (ALS8) is a familial form of motor neuron disease, with predominance of lower motor neuron degeneration, and is caused by mutation of the vesicle-associated membrane protein-associated protein B (VAPB). " 11/01/2016 - "Four mutations in the VAMP/synaptobrevin-associated protein B (VAPB) gene have been linked to amyotrophic lateral sclerosis (ALS) type 8. The mechanism by which VAPB mutations cause motor neuron disease is unclear, but studies of the most common P56S variant suggest both loss of function and dominant-negative sequestration of wild-type protein. " 05/01/2012 - "A proline-to-serine substitution at position 56 in the gene encoding vesicle-associated membrane protein-associated protein B (VAPB; VAPBP56S) causes some dominantly inherited familial forms of motor neuron disease, including amyotrophic lateral sclerosis (ALS) type-8. " 03/15/2012 - "A proline to serine substitution at position 56 in the gene encoding vesicle-associated membrane protein-associated protein B (VAPB) causes some dominantly inherited familial forms of motor neuron disease including amyotrophic lateral sclerosis (ALS) type-8. "
4.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2018 - "This study aims to investigate the association of vesicle-associated membrane protein 5 (VAMP5) and mutated in colorectal cancer (MCC) genetic polymorphisms and their correlated risks with HSCR. " 09/09/2009 - "Time-lapse confocal microscopy imaging of individual RGC axons coexpressing GFP-synaptobrevin and DsRed in the intact Xenopus brain demonstrated a role for deleted in colorectal cancer (DCC)-mediated netrin signaling. "
5.	Coronary Disease (Coronary Heart Disease) 06/01/2010 - "To investigate the association of synaptobrevins/vesicle-associated membrane proteins 8 (VAMP8) gene rs1010 polymorphism with coronary heart disease (CHD) in Chinese Han population. " 06/01/2010 - "[Association of the polymorphism of synaptobrevins/vesicle-associated membrane proteins 8 gene with coronary heart disease in Chinese Han population]." 02/01/2012 - "Single nucleotide polymorphisms (SNPs) at the KIF6 (kinesin like protein 6, rs20455 or 719Arg), LPA (lipoprotein(a), rs3798220), TAS2R50 (taste receptor type 2, member 50, rs1376251) and VAMP8 (vesicle-associated membrane protein 8, rs1010) have previously been associated with low density lipoprotein cholesterol (LDL-C) lowering response to statins, coronary heart disease (CHD) at baseline, or CHD events on trial. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Thioredoxins
3.	IgA receptor (protein B)
4.	SNARE Proteins (SNAREs)
5.	Staphylococcal Protein A (Protein A)
6.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
7.	Lipoprotein(a)
8.	Kinesins
9.	LDL Cholesterol
10.	Circular RNA

Related Therapies and Procedures

1.	Radiotherapy