Core Binding Factor Alpha 3 Subunit

A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain.

Also Known As:

AML2 Protein; Acute Myeloid Leukemia 2 Protein; CBFA3 Protein; Core-Binding Factor Alpha 3 Protein; PEBP2A3 Protein; Runt Domain Transcription Factor AML-2; Runt-Related Transcription Factor 3 Protein; Runx3 Protein; Core Binding Factor Alpha 3 Protein; Runt Related Transcription Factor 3 Protein

Networked: 48 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Core Binding Factors: 400
      - Core Binding Factor alpha Subunits: 36
        Core Binding Factor Alpha 3 Subunit: 48
        human Runx3 protein
        mouse Runx3 protein
        zebrafish runx3 protein

Experts

1.	Ito, Yoshiaki: 7 articles (11/2011 - 07/2006)
2.	Ito, Kosei: 7 articles (10/2010 - 07/2006)
3.	Salto-Tellez, Manuel: 5 articles (10/2010 - 07/2006)
4.	Putti, Thomas Choudary: 3 articles (10/2010 - 07/2006)
5.	Ito, Hisao: 3 articles (01/2007 - 01/2005)
6.	Osaki, Mitsuhiko: 3 articles (01/2007 - 01/2005)
7.	Bai, Jin: 2 articles (01/2019 - 03/2016)
8.	Chen, Jie: 2 articles (12/2011 - 02/2011)
9.	Chan, Jason Yongsheng: 2 articles (10/2010 - 01/2009)
10.	Subramaniam, Manish Mani: 2 articles (10/2010 - 01/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "RUNX3 protein plays an important role in TGF-β signaling pathway that is involved in tumor growth inhibition and apoptosis. " 03/01/2016 - "RUNX3 is frequently inactivated in human cancer cell lines and cancer samples by hemizygous deletion of the Runx3 gene, hypermethylation of the Runx3 promoter, or cytoplasmic sequestration of RUNX3 protein. " 04/01/2015 - "The positive rates of Runx3 protein expression in ER positive and negative tumors were 26.5% (18/68) and 66.7% (30/45), respectively (P<0.05). " 09/01/2008 - "We observed a significantly more frequent loss of RUNX3 protein expression in the histologically higher-grade tumors (Grade 3) than in Grade 1 or 2 tumors (p<0.01). " 07/01/2008 - "The low level of RUNX3 protein in salivary ACCs might play a pivotal role in tumor progression and have prognostic values in ACCs."
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/2019 - "The present study aimed to determine the status of RUNX3 protein expression and its association with clinicopathological characteristics in tongue squamous cell carcinomas (SCC). " 01/01/2007 - "This study aimed to analyze the expression of the RUNX3 protein in human oral normal epithelia, dysplasia and squamous cell carcinomas (SCCs), comparing it with clinicopathological profiles. " 01/01/2005 - "This study examined the expression of RUNX3 protein in human esophageal mucosa and squamous cell carcinoma in comparison with clinicopathological profiles. " 01/01/2019 - "Inactivation of RUNX3 protein expression in tongue squamous cell carcinoma and its association with clinicopathological characteristics." 01/01/2005 - "Expression of RUNX3 protein in human esophageal mucosa and squamous cell carcinoma."
3.	Stomach Neoplasms (Stomach Cancer) 09/01/2006 - "Our previous studies suggested that deficient function of RUNX3 protein is causally related to development and progression of human gastric cancer. " 01/01/2018 - "In human gastric cancer tissues, HOTAIR was negatively associated with the expression level of Runx3 protein (Pearson coefficient - 0.501, p = 0.025). " 02/01/2013 - "Antitumor activity of cell-permeable RUNX3 protein in gastric cancer cells." 07/01/2008 - "To analyze the relationships among the aberrant methylation of Runx3 gene promoter, the Runx3 protein expression and clinicopathological features in gastric cancer. " 03/01/2007 - "RUNX3 protein influences the differentiation of gastric cancer. "
4.	Carcinoma (Carcinomatosis) 02/01/2011 - "To investigate the expression of RUNX3 protein in hepatic cell carcinoma (HCC) and its relationship with the clinicopathological factors of HCC. " 02/01/2011 - "[Expression of RUNX3 protein in hepatic cell carcinoma and its clinicopathological implications]." 09/01/2004 - "To investigate the RUNX3 protein expression in human gastric mucosa and carcinoma, we generated a polyclonal antibody, AS251, which recognized amino acid sequences from 251 to 266 of human RUNX3. " 01/01/2011 - "In the present study, exogenous Run3 was transiently expressed in AGS (human gastric adenocarcinoma), with undetectable Runx3 protein and in A549 (human lung carcinoma) with low levels of endogenous Runx3 protein. " 01/01/2019 - "In the 79 patients with tongue SCC, RUNX3 protein expression was presented in different manners in carcinoma nests and tumor stroma. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2008 - "The expression of RUNX3 protein has a definite value in judging prognosis in breast cancer." 01/01/2008 - "With the increased progression of breast cancer, the expression of RUNX3 protein tends to decrease. " 01/01/2008 - "Immunohistochemical study was performed to analyze RUNX3 protein expression in 88 breast cancer tissues and 40 breast fibroadenomas. " 05/01/2012 - "RUNX3 is frequently inactivated in human breast cancer cell lines and cancer samples by hemizygous deletion of the Runx3 gene, hypermethylation of the Runx3 promoter, or cytoplasmic sequestration of RUNX3 protein. " 01/01/2008 - "Immunohistochemistry results revealed that the positive rate of RUNX3 protein expression in breast cancer (35.23%) was much lower than that in breast fibroadenoma (85%). "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Proteins (Proteins, Gene)
3.	Complementary DNA (cDNA)
4.	Genistein
5.	Transforming Growth Factor beta (TGF-beta)
6.	Gastrins
7.	Flavonoids
8.	Monoclonal Antibodies
9.	Decitabine
10.	xylometazoline (stas)

Related Therapies and Procedures

1.	Neoadjuvant Therapy
2.	Aftercare (After-Treatment)