HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Succinate-Semialdehyde Dehydrogenase (Succinic Semialdehyde Dehydrogenase)

An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).
Also Known As:
Succinic Semialdehyde Dehydrogenase; NAD(+)-Dependent Succinic Semialdehyde Dehydrogenase; Succinate Semialdehyde Dehydrogenase; Dehydrogenase, Succinate Semialdehyde; Dehydrogenase, Succinate-Semialdehyde; Dehydrogenase, Succinic Semialdehyde; Semialdehyde Dehydrogenase, Succinate; Semialdehyde Dehydrogenase, Succinic
Networked: 36 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Gibson, K Michael: 10 articles (01/2013 - 01/2003)
2. Gibson, K M: 8 articles (06/2009 - 10/2001)
3. Snead, O Carter: 7 articles (03/2009 - 01/2003)
4. Jakobs, C: 6 articles (06/2009 - 10/2001)
5. Jakobs, Cornelis: 3 articles (01/2013 - 01/2003)
6. Choi, Soo Young: 3 articles (10/2009 - 07/2002)
7. Gupta, Maneesh: 3 articles (02/2006 - 01/2003)
8. Snead, O C: 3 articles (11/2004 - 10/2001)
9. Sander, Thomas: 2 articles (12/2011 - 04/2006)
10. Hwang, In Koo: 2 articles (10/2009 - 02/2003)

Related Diseases

1. Seizures (Seizure)
2. Ischemia
3. Ataxia (Dyssynergia)
4. Mental Retardation (Idiocy)
5. Absence Epilepsy (Absence Seizure)

Related Drugs and Biologics

1. gamma-Aminobutyric Acid (GABA)
2. Glutamate Decarboxylase (Decarboxylase, Glutamate)
3. Enzymes
4. 4-hydroxybutyrate dehydrogenase
5. ebselen
6. 4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)
7. Neurotransmitter Agents (Neurotransmitter)
8. Aromatic Amino Acids (Aromatic Amino Acid)
9. Glutamic Acid (Glutamate)
10. Succinate Dehydrogenase (Fumarate Reductase)