|1.||Porter, Todd D: 2 articles (03/2005 - 01/2005)|
|2.||Mokashi, Vishwesh: 2 articles (03/2005 - 01/2005)|
|3.||Singh, Puneet Kumar: 1 article (09/2015)|
|4.||Shukla, Pratyoosh: 1 article (09/2015)|
|5.||Karumuri, Sudha: 1 article (09/2015)|
|6.||Cheng, Zhangjun: 1 article (08/2015)|
|7.||Zhou, Jiahua: 1 article (08/2015)|
|8.||Lu, Penhua: 1 article (08/2015)|
|9.||Sui, Zhenghui: 1 article (08/2015)|
|10.||Michihara, Akihiro: 1 article (01/2015)|
12/01/2011 - "Research on new squalene monooxygenase inhibitors is important due to the prevalence of hypercholesterolemia and the lack of both sufficient and safe remedies. "
07/15/1991 - "From these observations, squalene epoxidase inhibitor is expected to be highly effective in the treatment of hypercholesterolemia and also is very useful as a research tool for studying the regulation of cholesterol metabolism."
12/01/2011 - "In this paper we (i) review data on activity and the structure of squalene monooxygenase, (ii) present its inhibitors, (iii) compare current strategies of lowering cholesterol level in blood with some of the most promising strategies, (iv) underline advantages of squalene monooxygenase as a target for hypercholesterolemia therapy, and (v) discuss safety concerns about hypercholesterolemia therapy based on inhibition of cellular cholesterol biosynthesis and potential usage of squalene monooxygenase inhibitors in clinical practice. "
12/01/2011 - "Squalene monooxygenase downregulation in vertebrates and fungi decreases synthesis of cholesterol and ergosterol, respectively, which makes squalene monooxygenase a potent and attractive target of hypercholesterolemia and antifungal therapies. "
|2.||Demyelinating Diseases (Demyelinating Disease)
10/01/1998 - "All three organotellurium compounds caused inhibition of squalene epoxidase in vitro and caused demyelination in vivo. "
10/01/1998 - "K2TeO3 had no effect on squalene epoxidase activity in cultured Schwann cells and caused no demyelination in vivo. "
10/01/1998 - "These data are consistent with the hypothesis that tellurium-induced demyelination is a result of squalene epoxidase inhibition and suggest that a dimethyltelluronium compound may be the neurotoxic species presented to Schwann cells in vivo."
10/01/1998 - "We examined potassium tellurite (K2TeO3) and three organotellurium compounds for their ability to inhibit squalene epoxidase in Schwann cell cultures and to induce demyelination in weanling rats. "
10/01/1998 - "Exposure of weanling rats to a diet containing 1% elemental tellurium causes segmental demyelination of peripheral nerve, and an inhibition of squalene epoxidase. "
|3.||Hepatocellular Carcinoma (Hepatoma)
08/01/2015 - "Squalene epoxidase (SQLE) promotes the growth and migration of the hepatocellular carcinoma cells."
11/01/1990 - "Regulation of squalene epoxidase in the cholesterol biosynthetic pathway was studied in a human hepatoma cell line, HepG2 cells. "
03/01/2005 - "Supernatant protein factor (SPF) is a poorly characterized cytosolic protein that stimulates HMG-CoA reductase and squalene monooxygenase in vitro and cholesterol synthesis when expressed in hepatoma cells. "
01/15/2005 - "Evaluation of 2,3-oxidosqualene synthesis from [(14)C]mevalonate demonstrated that SPF also stimulated squalene monooxygenase (1.3-fold) in hepatoma cells. "
09/01/2015 - "It is evident that enzyme squalene epoxidase is responsible for prolonged dermatophyte infection and it is appealing to note that this enzyme is also responsible for fatty acid synthesis in these groups of fungi. "
07/01/2003 - "With a fungicidal activity, low minimum inhibitory concentration value, and high selectivity for fungal squalene epoxidase, terbinafine has demonstrated good efficacy in superficial fungal infections. "
05/05/2007 - "Terbinafine is an allylamine antifungal agent that has been proven to have high clinical efficacy in the therapy of fungal infections, the mechanism of action of terbinafine involves the specific inhibition of fungal squalene epoxidase, resulting in ergosterol deficiency and accumulation of intracellular squalene. "
07/01/2009 - "Here we report that the Arabidopsis drought hypersensitive/squalene epoxidase 1-5 (dry2/sqe1-5) mutant, identified by its extreme hypersensitivity to drought stress, has altered stomatal responses and root defects because of a point mutation in the SQUALENE EPOXIDASE 1 (SQE1) gene. "
03/01/2014 - "Highest squalene levels (over 1000 μg squalene per 10(9) cells) were induced by specific point mutations in ERG1 gene that reduced activity of squalene epoxidase and caused hypersensitivity to terbinafine. "
|5.||Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)
|8.||Scavenger Receptors (Scavenger Receptor)
|9.||Estrogen Receptor Modulators (Antiestrogen)