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Squalene Monooxygenase (Squalene Epoxidase)

The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
Also Known As:
Squalene Epoxidase; Squalene Monooxygenase (2,3-Epoxidizing); Epoxidase, Squalene; Monooxygenase, Squalene
Networked: 24 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Porter, Todd D: 2 articles (03/2005 - 01/2005)
2. Mokashi, Vishwesh: 2 articles (03/2005 - 01/2005)
3. Singh, Puneet Kumar: 1 article (09/2015)
4. Shukla, Pratyoosh: 1 article (09/2015)
5. Karumuri, Sudha: 1 article (09/2015)
6. Cheng, Zhangjun: 1 article (08/2015)
7. Zhou, Jiahua: 1 article (08/2015)
8. Lu, Penhua: 1 article (08/2015)
9. Sui, Zhenghui: 1 article (08/2015)
10. Michihara, Akihiro: 1 article (01/2015)

Related Diseases

1. Hypercholesterolemia
2. Demyelinating Diseases (Demyelinating Disease)
3. Hepatocellular Carcinoma (Hepatoma)
4. Infection
5. Hypersensitivity (Allergy)

Related Drugs and Biologics

1. Cholesterol
2. Squalene
3. terbinafine (Lamisil)
4. Tellurium
5. Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)
6. Ergosterol (Lumisterol)
7. Allylamine
8. Scavenger Receptors (Scavenger Receptor)
9. Estrogen Receptor Modulators (Antiestrogen)
10. Simvastatin (Zocor)