|1.||Torbati, Mohammadali: 1 article (10/2015)|
|2.||Ebrahimi-Mamaghani, Mehrangiz: 1 article (10/2015)|
|3.||Mostafaei, Somaiyeh: 1 article (10/2015)|
|4.||Baradaran, Behzad: 1 article (10/2015)|
|5.||Arefhosseini, Seyed Rafie: 1 article (10/2015)|
|6.||Sadeghihokmabad, Elyar: 1 article (10/2015)|
|7.||Rezapour-Firouzi, Soheila: 1 article (10/2015)|
|8.||Chehreh, Mahtaj: 1 article (10/2015)|
|9.||Kägi, Roland: 1 article (02/2014)|
|10.||Ferrari, Giovanni: 1 article (02/2014)|
|1.||Atopic Dermatitis (Atopic Eczema)
02/01/1992 - "Recently a defect in the function of the enzyme delta-6-desaturase has been discussed as a major factor in the development of atopic eczema. "
06/01/1984 - "These observations suggest that atopic eczema is associated not with any defect of EFA intake, but with abnormal metabolism, possibly involving the enzyme delta-6-desaturase. "
01/01/1988 - "It has been reported that essential fatty acid levels may be low and that there may be reduced levels of delta-6-desaturase metabolites of linoleic acid in patients with atopic eczema. "
01/01/1985 - "The conclusion is that evening primrose oil improves atopic dermatitis; an abnormality of the enzyme delta-6-desaturase is proposed to explain the biochemical findings. "
02/01/2014 - "Atopic dermatitis (AD) has been related to a deficiency of delta-6-desaturase, an enzyme responsible for the conversion of linoleic acid to gamma-linolenic acid (GLA). "
11/01/1983 - "Recent studies on the effects of the essential fatty acid metabolic intermediate, gamma-linolenic acid, on the growth of cancer cells in culture and on induced mammary cancer tumours in rats, strongly suggest that the metabolic defect in the cancer cells studied is simply a metabolic block involving the enzyme delta-6-desaturase. "
07/01/2009 - "There was an increased Delta-6-desaturase and Delta-9 desaturase enzyme activities and reduced estimated Delta-5-desaturase activity in tumors from mice fed the SDA diet. "
08/01/2003 - "Highly unsaturated fatty acids (HUFAs) are cyto-toxic to cancer cells and generated in the body by desaturation from essential fatty acids, primarily involving delta-6-desaturase. "
07/01/2009 - "We also examined the percent unsaturated or saturated fatty acids in the total phospholipids, PUFA omega-6/omega-3 ratios, and other major enzymes (elongase, Delta [Delta]-5-desaturase, and Delta-6-desaturase) of omega-6 catabolic pathways from the tumors. "
01/01/2000 - "Several studies have shown that the activities of delta-6-desaturase and delta-5-desaturase are depressed in experimental diabetes and in humans with insulin- and non-insulin-dependent diabetes mellitus (type I and type II diabetes mellitus respectively). "
08/01/1983 - "Aging, sex, diabetes mellitus, alcohol, catecholamines and trans fatty acids and saturated fats can all modulate the delta-6-desaturase enzyme which converts linoleic acid to gamma-linolenic acid. "
|4.||Breast Neoplasms (Breast Cancer)
08/01/2003 - "This study, for the first time, examined the level of expression of human delta-6-desaturase as well as delta-4-desaturase in human breast cancer. "
08/01/2003 - "Tumours from patients who had a poor prognostic index and from those who died of breast cancer had the lowest level of delta-6-desaturase (median follow-up 72 months). "
08/01/2003 - "Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer."
06/01/2013 - "Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue."
|5.||Relapsing-Remitting Multiple Sclerosis
|2.||delta-5 fatty acid desaturase
|6.||Efamol (evening primrose oil)
|7.||Secretory Phospholipases A2
|9.||Linoleic Acid (Linoleate)
|10.||Arachidonic Acid (Vitamin F)