Trans-Cinnamate 4-Monooxygenase (Trans Cinnamate 4 Monooxygenase)

A member of the P450 superfamily, this enzyme catalyzes the first oxidative step of the phenylpropanoid pathway in higher PLANTS by transforming trans-cinnamate into p-coumarate.

Also Known As:

Trans Cinnamate 4 Monooxygenase; Cinnamate 4-Hydroxylase; Trans-Cinnamate 4-Monooxygenase CYP73; Trans-Cinnamic Acid 4-Hydroxylase; 4-Hydroxylase, Cinnamate; 4-Hydroxylase, Trans-Cinnamic Acid; 4-Monooxygenase CYP73, Trans-Cinnamate; 4-Monooxygenase, Trans-Cinnamate; Acid 4-Hydroxylase, Trans-Cinnamic; CYP73, Trans-Cinnamate 4-Monooxygenase; Cinnamate 4 Hydroxylase; Trans Cinnamate 4 Monooxygenase CYP73; Trans Cinnamic Acid 4 Hydroxylase

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Trans-Cinnamate 4-Monooxygenase: 6
        Arabidopsis CYP73A5 protein
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Trans-Cinnamate 4-Monooxygenase: 6
      - Arabidopsis CYP73A5 protein

Experts

1.	Feng, Ke: 1 article (09/2019)
2.	Guan, Yuge: 1 article (09/2019)
3.	Hou, Mengyang: 1 article (09/2019)
4.	Hu, Wenzhong: 1 article (09/2019)
5.	Ji, Yaru: 1 article (09/2019)
6.	Jiang, Aili: 1 article (09/2019)
7.	Sa, Rengaowa: 1 article (09/2019)
8.	Xu, Yongping: 1 article (09/2019)
9.	Yang, Xiaozhe: 1 article (09/2019)
10.	Yu, Jiaoxue: 1 article (09/2019)

Related Diseases

1.	Disease Resistance 01/01/2005 - "ABSTRACT In this study, cucumber plants (Cucumis sativus) expressing induced resistance against powdery mildew (caused by Podosphaera xanthii) were infiltrated with inhibitors of cinnamate 4-hydroxylase, 4-coumarate:CoA ligase (4CL), and chalcone synthase (CHS) to evaluate the role of flavonoid phytoalexin production in induced disease resistance. "
2.	Infections 05/01/2023 - "In the phenylpropane metabolic pathway, the activities of phenylalanine ammonia-lyase (PAL), cinnamate 4-hydroxylase (C4H), and 4-coumaric acid coenzyme A ligase (4CL) were increased during the activation of grape berries during the resistance to pathogen infection by SNP, and the intermediate metabolites lignin, flavonoids, and total phenols were accumulated. " 10/16/2023 - "Assays with four different cultivars of melon with differing levels of mildew resistance demonstrated that relative to the control, the Nano-Se treatment resulted in larger responses to mildew infection, including increases in the levels of putrescine (PUT; 43-112%) and spermine (SPM; 36-118%), indoleacetic acid (IAA; 43-172%) and salicylic acid (SA; 24-73%), the activities of phenylalanine ammonium lyase (PAL), trans-cinnamate 4-hydroxylase (C4H) and 4-coumarate: Co A ligase (4CL) of the phenylpropanoid pathway (22-38%, 24-126% and 19-64%, respectively). "
3.	Tetraploidy 03/01/2008 - "Consensus primers, based on exon sequences of the cyp73 gene family coding for cinnamate 4-hydroxylase (C4H) of the lignin biosynthesis pathway, were designed for the tetraploid willow species Salix alba and Salix fragilis. "
4.	Wounds and Injuries (Trauma) 09/30/2019 - "Results show that MeJA treatment stimulated phenylalanine ammonia-lyase (PAL), cinnamate 4-hydroxylase (C4H), and 4-coumarin coenzyme A ligase (4CL) enzymes activities in phenylpropanoid metabolism, and inhibited the activity of polyphenol oxidase (PPO), and further accelerated the accumulation of the wound-induced rutin, caffeic acid, and cinnamic acid accumulation, which contributed to the result of the total phenolic content increasing by 34.8% and ferric reducing antioxidant power increasing by 154.9% in broccoli. "
5.	Dehydration (Water Stress) 06/01/2011 - "Our results indicate that water stress resulted in decreased shikimate pathway (DAHP synthase, shikimate dehydrogenase, phenylalanine ammonium lyase, cinnamate 4-hydroxylase, 4-coumarate CoA ligase) and phenolic compounds (caffeoylquinic acid derivatives, quercetin and kaempferol) in the cultivars more sensitive to water stress. "

Related Drugs and Biologics

1.	Ligases (Synthetase)
2.	Flavonoids
3.	Coenzyme A (CoA)
4.	flavanone synthetase (chalcone synthase)
5.	Ammonium Compounds
6.	Phenylalanine Ammonia-Lyase
7.	Phenylalanine (L-Phenylalanine)
8.	Lyases
9.	Lignin
10.	Coenzyme A Ligases (Acid-Thiol Ligases)