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Homogentisate 1,2-Dioxygenase (Homogentisate 1,2 Dioxygenase)

A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
Also Known As:
Homogentisate 1,2 Dioxygenase; Dioxygenase, Homogentisate; Homogentisic Acid Oxidase; Homogentisate Dioxygenase; Homogentisate Oxidase; Homogentisate Oxygenase; 1,2-Dioxygenase, Homogentisate; Acid Oxidase, Homogentisic; Oxidase, Homogentisate; Oxidase, Homogentisic Acid; Oxygenase, Homogentisate
Networked: 119 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Bernardini, Giulia: 10 articles (11/2015 - 10/2010)
2. Santucci, Annalisa: 10 articles (11/2015 - 10/2010)
3. Millucci, Lia: 10 articles (11/2015 - 10/2010)
4. Braconi, Daniela: 10 articles (11/2015 - 10/2010)
5. Laschi, Marcella: 6 articles (09/2015 - 10/2010)
6. Spreafico, Adriano: 6 articles (01/2014 - 10/2010)
7. Gallagher, James A: 5 articles (09/2015 - 10/2010)
8. Ranganath, Lakshminarayan R: 5 articles (09/2015 - 12/2011)
9. Lupetti, Pietro: 5 articles (09/2015 - 11/2012)
10. Bernardini, Isa: 5 articles (12/2009 - 09/2002)

Related Diseases

1. Alkaptonuria
2. Ochronosis
3. Metabolic Diseases (Metabolic Disease)
4. Arthritis (Polyarthritis)
5. Rare Diseases (Rare Disease)

Related Drugs and Biologics

1. Homogentisic Acid
2. Tyrosine (L-Tyrosine)
3. Phenylalanine (L-Phenylalanine)
4. Melanins (Melanin)
5. Polymers
6. Alkaptonuric ochronosis
7. Aromatic Amino Acids (Aromatic Amino Acid)
8. Tyrosine Transaminase (Tyrosine Aminotransferase)
9. Messenger RNA (mRNA)
10. Oxidoreductases