|1.||de Koning, T J: 4 articles (02/2011 - 12/2000)|
|2.||Jaeken, J: 4 articles (05/2002 - 09/2000)|
|3.||Pineda, M: 3 articles (05/2002 - 09/2000)|
|4.||Van Schaftingen, E: 2 articles (01/2016 - 09/2000)|
|5.||Wiame, Elsa: 2 articles (01/2016 - 07/2012)|
|6.||Mattaini, Katherine R: 2 articles (02/2015 - 09/2011)|
|7.||Vander Heiden, Matthew G: 2 articles (02/2015 - 09/2011)|
|8.||Heng, Wei: 2 articles (01/2015 - 10/2013)|
|9.||Yafei, Qi: 2 articles (01/2015 - 10/2013)|
|10.||Jing, Zhang: 2 articles (01/2015 - 10/2013)|
01/02/2015 - "p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation."
11/15/1999 - "Shifting rats to a protein-free, carbohydrate-rich diet, although not starvation, resulted in the appearance of mRNA for, and activity of, 3-phosphoglycerate dehydrogenase (3-PGDH) in liver as well as in a marked decrease in plasma cystine concentration. "
04/01/1973 - "1. The degradation rates and half-lives of hexokinase, 6-phosphogluconate dehydrogenase, lactate dehydrogenase, pyruvate kinase, glucose 6-phosphate dehydrogenase, phosphoglycerate kinase and aldolase were calculated from measurements of the decline in activities of these enzymes in rat small intestine during starvation. "
04/01/2015 - "Quantitative reverse transcription-polymerase chain reaction and immunohistochemical analysis confirmed that expression of phosphoglycerate dehydrogenase consistently increases during progression of CIN toward cancer. "
08/18/2011 - "Among the genes identified, phosphoglycerate dehydrogenase (PHGDH) is in a genomic region of recurrent copy number gain in breast cancer and PHGDH protein levels are elevated in 70% of oestrogen receptor (ER)-negative breast cancers. "
10/16/2014 - "Human cancers often exhibit overexpression of phosphoglycerate dehydrogenase (PHGDH), the metabolic enzyme that catalyses the reaction that diverts serine biosynthesis from the glycolytic pathway. "
10/01/2013 - "Phosphoglycerate dehydrogenase and serum SCC-Ag were both associated with International Federation of Gynecology and Obstetrics stage and tumor size (P < 0.05). "
10/01/2013 - "Phosphoglycerate dehydrogenase was more moderate/strong expressed in cervical cancer than in normal cervical epithelium (72% vs 28.6%, respectively; P < 0.05); furthermore, PHGDH and serum SCC-Ag expression in squamous cervical cancer were positively correlated (r = 0.310, P < 0.05). "
|3.||Melanoma (Melanoma, Malignant)
01/01/2011 - "Two recent studies found subsets of human melanoma and breast cancers to have high levels of phosphoglycerate dehydrogenase (PHGDH), a key enzyme for serine biosynthesis, and these cancer cells are dependent on PHGDH for their growth and survival. "
02/20/2015 - "Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma. "
|4.||Brain Ischemia (Cerebral Ischemia)
12/01/2014 - "Immunohistochemistry studies of brain tissue after cerebral ischemia showed that SRR is expressed in neurons, and 3-phosphoglycerate dehydrogenase (3-PGDH), which synthesizes L-serine from 3-phosphoglycerate, is located in astrocytes, supporting the results of the in vitro experiments. "
11/01/2009 - "3-phosphoglycerate dehydrogenase deficiency: a case report of a treatable cause of seizures."
12/01/2002 - "The convulsions associated with 3-phosphoglycerate dehydrogenase deficiency can be completely abolished with amino acid therapy. "
02/01/2011 - "3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency is considered to be a rare cause of congenital microcephaly, infantile onset of intractable seizures and severe psychomotor retardation. "
04/01/2006 - "These enzyme defects lead to severe neurological symptoms such as congenital microcephaly and severe psychomotor retardation and in addition in patients with 3-phosphoglycerate dehydrogenase deficiency to intractable seizures. "
08/01/2001 - "In contrast to reports in the literature, these findings demonstrate that congenital microcephaly, intractable seizures, and dysmyelinisation are not invariably present in patients with 3-phosphoglycerate dehydrogenase deficiency. "
|1.||Staphylococcal Protein A (A, Protein)
|2.||Messenger RNA (mRNA)
|5.||3-phosphoglycerate (glycerate 3-phosphate)
|6.||Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)
|8.||phosphoserine aminotransferase (phosphoserine transaminase)
|9.||Complementary DNA (cDNA)