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Hydroxypyruvate Reductase

An enzyme that catalyzes the oxidation of D-glycerate to hydroxypyruvate in the presence of NADP.
Also Known As:
Beta-Hydroxypyruvate Reductase; Beta Hydroxypyruvate Reductase; Reductase, Beta-Hydroxypyruvate; Reductase, Hydroxypyruvate
Networked: 18 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Rumsby, Gill: 3 articles (03/2006 - 12/2003)
2. Takayama, Tatsuya: 2 articles (03/2012 - 12/2008)
3. Danpure, Christopher J: 2 articles (03/2006 - 01/2004)
4. Williams, Emma L: 2 articles (03/2006 - 12/2003)
5. Gareau, Melanie G: 1 article (01/2021)
6. Hennessey, Carly: 1 article (01/2021)
7. Heskett, Christopher W: 1 article (01/2021)
8. Marchant, Jonathan S: 1 article (01/2021)
9. Said, Hamid M: 1 article (01/2021)
10. Subramanian, Veedamali S: 1 article (01/2021)

Related Diseases

1. Primary hyperoxaluria type 2
2. Primary Hyperoxaluria (Oxaluria, Primary)
10/01/1999 - "The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II."
01/01/2018 - "Primary hyperoxaluria Type II and primary hyperoxaluria Type III are due to the deficit of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) and 4-hydroxy-2-oxoglutarate aldolase (HOGA1), respectively. "
08/01/2000 - "Primary hyperoxaluria type II (PH2) is a rare disease characterized by the absence of an enzyme with glyoxylate reductase, hydroxypyruvate reductase, and D-glycerate dehydrogenase activities. "
01/09/2004 - "The primary hyperoxalurias type 1 (PH1) and type 2 (PH2) are autosomal recessive calcium oxalate kidney stone diseases caused by deficiencies of the metabolic enzymes alanine:glyoxylate aminotransferase (AGT) and glyoxylate/hydroxypyruvate reductase (GR/HPR), respectively. "
03/01/2006 - "Failure to detoxify the intermediary metabolite glyoxylate in human hepatocytes underlies the metabolic pathology of two potentially lethal hereditary calcium oxalate kidney stone diseases, PH (primary hyperoxaluria) types 1 and 2. In order to define more clearly the roles of enzymes involved in the metabolism of glyoxylate, we have established singly, doubly and triply transformed CHO (Chinese-hamster ovary) cell lines, expressing all combinations of normal human AGT (alanine:glyoxylate aminotransferase; the enzyme deficient in PH1), GR/HPR (glyoxylate/hydroxypyruvate reductase; the enzyme deficient in PH2), and GO (glycolate oxidase). "
3. Kidney Calculi (Kidney Stone)
4. Obesity
5. Rare Diseases (Rare Disease)

Related Drugs and Biologics

1. glyoxylate reductase
2. Enzymes
3. glyoxylic acid (glyoxylate)
4. Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)
5. Oxalates
6. Proteins (Proteins, Gene)
7. Oxidoreductases (Dehydrogenase)
8. Calcium Oxalate
9. Hemoglobin Subunits
10. Peroxiredoxins