|1.||Somlo, Stefan: 5 articles (12/2014 - 06/2003)|
|2.||Harris, Peter C: 4 articles (10/2015 - 09/2003)|
|3.||Tian, Xin: 4 articles (12/2014 - 06/2003)|
|4.||Basdra, Efthimia K: 3 articles (11/2015 - 01/2015)|
|5.||Piperi, Christina: 3 articles (11/2015 - 01/2015)|
|6.||Cai, Yiqiang: 3 articles (12/2014 - 09/2003)|
|7.||Devuyst, Olivier: 3 articles (07/2013 - 05/2003)|
|8.||Guggino, William B: 3 articles (01/2011 - 09/2002)|
|9.||Delmas, Patrick: 3 articles (10/2009 - 10/2004)|
|10.||Chen, Xing-Zhen: 3 articles (11/2008 - 08/2002)|
05/01/2008 - "New approaches based on cell culture of cyst wall epithelia and on the discovery of polycystins 1 and 2 have lead to novel treatment protocols to attack the origin of the disease. "
10/01/2015 - "A polycystin-centric view of cyst formation and disease: the polycystins revisited."
09/01/2013 - "We investigated the mechanisms of cyst formation in these two distinct processes by combining conditional inactivation of polycystins with concomitant ablation of cilia in developing and adult kidney and liver. "
12/01/2005 - "The characterization of this protein, which does not share structural homologies with known polycystins, may give new insights into the pathophysiology of renal cyst development in patients."
09/01/2002 - "The present review provides a hint of how malfunction of polycystins may give rise to cysts, based on recent observations concerning polycystin channels. "
|2.||Autosomal Dominant Polycystic Kidney (ADPKD)
03/01/2010 - "The study of autosomal dominant polycystic kidney disease (ADPKD), caused by inactivating mutations of PKD1 or PKD2 genes, has elucidated the functions of polycystins and their interdependence on primary cilia in renal epithelial cells. "
01/01/2006 - "The study of the polycystins has revealed some entirely novel insights into fundamental cell biology but these have not yet been satisfactorily integrated into a verified pathogenetic pathway for the development of ADPKD."
11/18/2014 - "However, how mutated polycystins predispose patients with ADPKD to cardiac pathologies before development of renal dysfunction is unknown. "
09/01/2011 - "Failure of mutant polycystins to localize to cilia abolishes flow-stimulated calcium signaling and causes autosomal dominant polycystic kidney disease. "
01/01/2011 - "Dysregulation of Ca(2+) signaling and homeostasis has been linked to the development of ADPKD through aberrant functioning of the polycystins. "
|4.||Polycystic Kidney Diseases (Polycystic Kidney Disease)
12/01/2014 - "Altered trafficking and stability of polycystins underlie polycystic kidney disease."
06/15/2014 - "Mutations of the two polycystins, PC1 and PC2, lead to polycystic kidney disease. "
12/25/2009 - "The PKD1 or PKD2 genes encode polycystins (PC) 1 and 2, which are associated with polycystic kidney disease. "
02/18/2005 - "Mutations in genes that encode polycystins 1 or 2 cause polycystic kidney disease (PKD). "
04/01/2004 - "Polycystins: what polycystic kidney disease tells us about sperm."
10/27/2001 - "Furthermore, modifying genes might directly affect the function of polycystins by affecting the rate of somatic mutations or the rate of protein interactions, or they might affect cystogenesis itself or clinical factors associated with disease progression. "
05/01/2003 - "These results also suggest that polycystins can participate in the regulation of endothelial NO synthase (eNOS) and that addressing endothelial dysfunction in ADPKD can offer a new perspective to slow renal disease progression."
|1.||Proteins (Proteins, Gene)
|4.||Membrane Proteins (Integral Membrane Proteins)
|5.||Nitric Oxide Synthase (NO Synthase)
|6.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|10.||Ion Channels (Ion Channel)