|2.||Hypertension (High Blood Pressure)
|3.||Cardiovascular Diseases (Cardiovascular Disease)
|1.||Folsom, Aaron R: 111 articles (01/2016 - 02/2002)|
|2.||Ballantyne, Christie M: 98 articles (11/2015 - 03/2002)|
|3.||Libby, Peter: 98 articles (11/2015 - 01/2002)|
|4.||Weber, Christian: 91 articles (12/2015 - 01/2002)|
|5.||Rader, Daniel J: 82 articles (11/2015 - 05/2002)|
|6.||Budoff, Matthew J: 76 articles (12/2015 - 02/2003)|
|7.||Boerwinkle, Eric: 75 articles (08/2015 - 02/2002)|
|8.||Witztum, Joseph L: 74 articles (07/2015 - 01/2002)|
|9.||Lusis, Aldons J: 72 articles (12/2015 - 01/2002)|
|10.||Daugherty, Alan: 70 articles (10/2015 - 01/2002)|
02/01/2007 - "Studies in genetically engineered mice revealed that SR-BI plays an important role in HDL reverse cholesterol transport and protection against atherosclerosis. "
07/01/2015 - "It plays an important role in the clearance of cholesterol from circulation, and thereby slows down the process of atherosclerosis. "
11/01/2003 - "Although surgical, endovascular, and medical therapies for atherosclerosis in general, and PAD specifically, continue to be developed, there appears to be considerable room for improvement in physician adoption of proven effective therapies, such as cholesterol-lowering therapies and blood pressure management. "
07/01/2001 - "Although the accumulation of cholesterol and other lipidic material is unquestionably important in atherogenesis, the reasons why this material progressively accumulates, rather than being effectively cleared by phagocytic cells such as macrophages, are not completely understood. "
01/01/2013 - "Further, an in vivo study was also conducted to confirm upon the efficacy of CS seed extract in alleviating pathophysiological alterations of high cholesterol diet induced atherosclerosis in rats. "
09/01/2005 - "High-density lipoprotein (HDL) plays an important role in protection against atherosclerosis. "
08/01/2014 - "High-density lipoprotein (HDL) confers protection against atherosclerosis by several different mechanisms. "
06/01/2012 - "High-density lipoprotein (HDL) is protective against atherosclerosis development. "
08/01/2009 - "High-density lipoprotein (HDL) and 17beta-estradiol independently provide protection against atherosclerosis. "
08/01/2006 - "In our view, CETP inhibitors in combination with statins will be profoundly beneficial in reducing human atherosclerosis, primarily because they normalize HDL particles and prevent the transfer of cholesteryl ester from HDL to atherogenic lipoproteins."
|3.||Apolipoproteins E (ApoE)IBA
01/01/2006 - "There was an important strain-dependence of the effect, with no protection against atherosclerosis in apoE(-/-) mice."
01/01/2012 - "Uncoupling of eNOS occurs in apoE(-/-) atherosclerosis but does not negate the enzyme's strong protective effects."
08/01/2008 - "TxA(2) receptor antagonism alone also afforded a significant reduction in atherosclerosis in apoE-deficient mice. "
05/01/2000 - "This notion has been further supported by a recent finding that administration of ET receptor antagonists resulted in a significant reduction of atherosclerosis in apoE-KO mice."
05/01/2000 - "We anticipate that pharmacological approaches to increase apoE synthesis and/or secretion by macrophages might be beneficial for the treatment of atherosclerosis."
12/01/2014 - "Tocopherol supplementation favorably influenced vascular function and cytokine profile, while it was also effective in reducing atherosclerosis in the apolipoprotein E(-/-) mouse with CKD."
05/01/2010 - "Studies on protective effects of human paraoxonases 1 and 3 on atherosclerosis in apolipoprotein E knockout mice."
06/01/2011 - "Furthermore, total or macrophage-specific FABP4 deficiency is protective against atherosclerosis in apolipoprotein E-deficient mice. "
12/01/2015 - "Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice."
06/10/2014 - "Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in apolipoprotein E(-/-) mice and rabbits. "
|5.||Insulin (Novolin)FDA Link
10/01/2008 - "A 6-month therapy with insulin sensitizers, MET and ROSI, resulted in marked improvement of endothelial function in young PCOS patients without clinically evident atherosclerosis who were not severely insulin resistant. "
12/01/2015 - "Inhibition of miR-33 has been demonstrated as protective against atherosclerosis; however, recent studies in mice suggest that miR-33 inhibition may have adverse effects on lipid and insulin metabolism. "
09/28/2012 - "Inhibition of TGH activity ameliorates atherosclerosis development and improves insulin sensitivity in Ldlr(-/-) mice."
10/08/2009 - "Molecular disruption of the lipid carrier AFABP/aP2 in mice results in improved insulin sensitivity and protection from atherosclerosis. "
03/01/2009 - "Insulin also appears to exhibit anti-inflammatory effects, which may provide additional protection against the development of atherosclerosis. "
|6.||Apolipoprotein A-I (Apolipoprotein A1)IBA
03/18/2008 - "Acute plaque regression observed after short-term apoA-I(Milano) administration was associated with a significant reduction in suspected makers of plaque vulnerability in an experimental model of atherosclerosis."
06/03/1985 - "One molecular variant, Apo AI-Milano, while leading to a significant reduction of HDL, does not seem to be associated with clinical atherosclerosis, but rather with a protection from the disease. "
05/01/1992 - "Conclusively, apo A1 is effective in preventing the development of experimental atherosclerosis. "
08/18/2003 - "However, overexpression of apolipoprotein A-I in animals has been shown to reduce progression and even induce regression of atherosclerosis, indicating that apolipoprotein A-I is directly protective against atherosclerosis. "
02/01/2014 - "Apolipoprotein A-I protection against atherosclerosis is dependent on genetic background."
06/01/2004 - "Animals receiving the novel AAV vectors realized nearly complete normalization of serum lipids and failed to develop the severe atherosclerosis that characterized the untreated animals; the AAV2 vector constructs demonstrated partial lipid correction and only a modest improvement in atherosclerosis. "
06/01/2014 - "At the end of 8 and 16 weeks, compared with the injury group, the combined preventive group had significant reduction in both the concentration of serum lipids and inflammatory factors and atherosclerosis formation, indicative of a multifaceted anti-atherosclerotic impact. "
01/01/2015 - "We concluded that the protective effects of AsIV in atherosclerosis injury may be related to regulating blood lipids, CD40-CD40L system, and SDF-1/CXCR4 biological axis. "
12/01/2014 - "Collectively, these data demonstrate that the accumulation of lipids in Abcg1(-/-) mice induces the specific expansion and localization of B-1 B cells, which secrete NAbs that may help to protect against the development of atherosclerosis. "
01/01/2010 - "Decreased level of atherogenic lipids in blood improved the course of obliterating atherosclerosis of the lower extremity vessels. "
|8.||Estrogens (Estrogen)FDA Link
12/01/2001 - "From these results we concluded that the most important atheroprotective effect of estrogen is the direct inhibition of atherosclerosis in the arterial wall, and improvement in lipid metabolism is of secondary importance."
05/01/1989 - "We conclude that estrogen is an important factor in the animals' "female protection" against diet-induced atherosclerosis. "
09/01/2000 - "Exercise, estrogens, and substitution of polyunsaturated fat for saturated fat are beneficial in the prevention of atherosclerosis. "
01/01/1994 - "Consequently, estrogens are believed to confer significant protection against coronary artery atherosclerosis (CAA). "
03/01/2013 - "Monkey studies provided clear evidence that HT was effective in slowing the progression of coronary artery atherosclerosis only when administered soon after surgical menopause and that benefit was lost if estrogen therapy was delayed until the plaques had become complicated. "
|9.||Biological Markers (Surrogate Marker)IBA
02/01/2004 - "Serum markers of atherosclerosis and vascular integrity also improved most in the combination group. "
04/01/2010 - "Cardiac biomarkers and imaging methods have emerged to help detect and quantify subclinical atherosclerosis, but many of these are not proven as cost-effective for use in clinical practice or for routine screening. "
07/01/2012 - "The brachial-ankle pulse wave velocity, which is one of the surrogate markers for atherosclerosis, was also significantly greater in the G3b group compared to the G3a group. "
01/01/2012 - "The possibility of combining circulating biomarkers with other methods such as non-invasive and invasive imaging is clinically attractive because this could contribute to the improved diagnosis and understanding of premature atherosclerosis pathogenesis."
08/01/2009 - "AGE+S is associated with a favorable improvement in oxidative biomarkers, vascular function, and reduced progression of atherosclerosis."
|10.||LDL Receptors (LDL Receptor)IBA
04/30/2007 - "These results show for the first time that this dual Tx inhibitor is effective in reducing atherogenesis in the LDL receptor deficient mice. "
03/01/2001 - "Identification of the gene in this region may lead to new insights into the mechanisms of LDL receptor-mediated uptake of LDL by cells and may help to identify further genetic risk factors for premature atherosclerosis."
09/01/2011 - "Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice."
05/01/2015 - "This study examines the effect of hepatocyte or myeloid cell deletion of GSK3α or GSK3β on atherosclerosis in low-density lipoprotein receptor (LDLR)(-/-) mice. "
01/01/2015 - "This study aimed to apply ultrasound biomicroscopy to evaluate aortic atherosclerotic progression in a low-density lipoprotein receptor (LDL-R) knockout mouse model of atherosclerosis. "
09/01/2015 - "Among the 165 analysed segments, prevalence of lipid-rich plaque (LRP) with superficial attenuation (30.9 vs. 1.2%, P < 0.001) or calcified LRP (13.6 vs. 2.4%, P = 0.03) was significantly greater in native atherosclerosis compared with transplant patients. "
06/01/1996 - "Staining intensity measurements revealed a significant reduction (P < 0.001) in the amount of eNOS present in areas of atherosclerosis as compared with normal veins and areas of vein graft with FIH changes alone. "
06/23/1989 - "Finally, the graft loss rate (from either death or retransplantation for atherosclerosis) was significantly greater in the CMV group. "
11/01/1985 - "Improvement in the degree of angina and its recurrence after bypass surgery are closely related to graft patency and subsequent development of atherosclerosis in the grafts or in the native coronary arteries."
09/01/2014 - "The present study suggests that the accelerated atherogenesis of the venous graft is attributable to its elevated filtration rate that may lead to both aggravated concentration polarization of LDLs and enhanced convective transport of LDLs into the graft wall."
|2.||Angioplasty (Angioplasty, Transluminal)
07/01/2010 - "All generic and disease-specific QOL scores show statistically significant improvement with angioplasty and/or supervised exercise in patients with claudication due to femoropopliteal atherosclerosis. "
05/01/1994 - "The drug may be useful for the treatment of vascular proliferative diseases such as restenosis following percutaneous transluminal angioplasty and atherosclerosis."
09/01/1982 - "These promising results suggest that transluminal angioplasty has a definite role in the management of atherosclerosis obliterans of iliac and femoropopliteal arteries."
04/01/2013 - "Thus further studies on C19 may provide a new treatment perspective for atherosclerosis and post-angioplasty restenosis."
02/01/2005 - "In the last 30 years, thousands of basic or clinical studies have been devoted to atherosclerosis or to the problem of restenosis after angioplasty. "
03/01/2007 - "Human studies suggest that high plasma HCII levels are protective against in-stent restenosis and atherosclerosis. "
09/01/2008 - "Endovascular treatment of symptomatic aortoiliac atherosclerosis at the aortoiliac bifurcation by means of a distal aortic stent or kissing stents can be used successfully with durable improvement in the majority of patients. "
05/01/2011 - "Optical coherence tomography (OCT) is emerging as a new gold standard for endovascular imaging of stents, atherosclerosis progression, vulnerable plaque, and neointimal proliferation. "
03/01/2015 - "Stop adding metal layers: Will bioabsorbable scaffolds become the gold standard for late in-stent restenosis and neo-atherosclerosis?"
08/01/2005 - "The efficacy of intracoronary stent implantation in treating severe atherosclerosis lesion in the segments proximal to the myocardial bridge is not affected by abnormal haemodynamic changes of myocardial bridges. "
|4.||Hormone Replacement Therapy (Therapy, Hormone Replacement)
11/09/2002 - "Hormone-replacement therapy (HRT) is more effective in healthy women (maintaining vascular health) than in older women with atherosclerosis (restoring endothelial dysfunction). "
10/01/2011 - "We suggest that thyroid hormone replacement therapy may help to prevent atherosclerosis in this group of patients."
08/01/2007 - "However, none of the randomized trials already conducted with hormone replacement therapy showed overall benefit by means of reducing clinical ischemic cardiovascular events and/or suppressing atherogenesis. "
04/01/2007 - "This was a cross-sectional study of 1973 postmenopausal women ages 45-84 yr, not taking hormone replacement therapy, in the Multi-Ethnic Study of Atherosclerosis baseline examination. "
08/01/2003 - "A prospective evaluation of the risk of QT prolongation with hormone replacement therapy: the atherosclerosis risk in communities study."
|5.||Coronary Artery Bypass (Coronary Artery Bypass Surgery)
09/01/2012 - "In the present study, we investigated the benefit of ascending aorta replacement in patients with severe aortic atherosclerosis who undergo coronary artery bypass surgery (CABG). "
12/01/2006 - "This study investigated the previously uncertain relationship of embolic load captured during coronary artery bypass grafting and the extent of ascending aortic atherosclerosis as measured by wall thickness. "
01/01/2006 - "The purpose of this study was to investigate the assessment of ascending aortic atherosclerosis with 16-multidetector computed tomography (16-MDCT) angiography prior to total endoscopic coronary artery bypass (TECAB) surgery. "
04/01/1997 - "Study of the excess RA and internal thoracic artery segments remaining after coronary artery bypass grafting demonstrated that the RA had a higher degree of atherosclerosis than the internal thoracic artery at the time of harvest. "
10/01/1996 - "This study investigated whether varying degrees of atherosclerosis of the descending aorta, as assessed by TEE, are an independent predictor of cardiac and neurologic outcome in patients undergoing coronary artery bypass grafting (CABG). "