Transient Receptor Potential Channels

A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
Also Known As:
TRP Cation Channels; TRP Membrane Proteins; Cation Channels, TRP; Channels, TRP Cation; Membrane Proteins, TRP; Proteins, TRP Membrane
Networked: 69 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results


1. Reinach, Peter S: 2 articles (11/2015 - 01/2012)
2. Yao, Xiao-Qiang: 2 articles (10/2014 - 08/2011)
3. Yang, Qin: 2 articles (10/2014 - 08/2011)
4. Underwood, Malcolm John: 2 articles (10/2014 - 08/2011)
5. Huang, Jun-Hao: 2 articles (10/2014 - 08/2011)
6. Makarewich, Catherine A: 2 articles (08/2014 - 11/2012)
7. Kubo, Hajime: 2 articles (08/2014 - 11/2012)
8. Berretta, Remus M: 2 articles (08/2014 - 11/2012)
9. Houser, Steven R: 2 articles (08/2014 - 11/2012)
10. Zhang, Hongyu: 2 articles (08/2014 - 11/2012)

Related Diseases

1. Pain (Aches)
2. Neuralgia (Stump Neuralgia)
01/01/2011 - "The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. "
01/01/2011 - "Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. "
01/01/2011 - "In subgroup 1 transient receptor potential vanilloid 1 1911A>G led to significantly less heat hyperalgesia, pinprick hyperalgesia and mechanical hypaesthesia (p = 0.006, p = 0.005 and p<0.001) and transient receptor potential vanilloid 1 1103C>G (rs222747, M315I) to cold hypaesthesia (p = 0.002), but there was absence of associations in subgroup 2. In this study we found no evidence that genetic variants of transient receptor potential channels are involved in the expression of neuropathic pain, but transient receptor potential channel polymorphisms contributed significantly to the somatosensory abnormalities of neuropathic pain patients."
11/15/2006 - "Functional inhibition of p75NTR suppressed injury-induced neuropathic pain and decreased the phosphorylation of TrkA and p38 mitogen-activated protein kinase, and the induction of transient receptor potential channels in dorsal root ganglion (DRG) neurons. "
08/01/2013 - "These will include agonists and antagonists of the transient receptor potential channels, a family of receptor proteins that play a role in the transduction of physical stress; sodium channel isoform specific antagonists; a recently approved dual-action opioid receptor agonist-norepinephrine reuptake inhibitor; gene therapy for neuropathic pain; and anti-nerve growth factor molecules. "
3. Hypersensitivity (Allergy)
4. Hyperalgesia
5. Inflammation

Related Drugs and Biologics

1. oxaliplatin (Eloxatin)
2. Proteinase-Activated Receptors
3. Sodium Channels (Sodium Channel)
4. Glucose (Dextrose)
5. Calcium
6. vanilloid receptor subtype 1
7. Ligand-Gated Ion Channels
8. Cannabinoid Receptors (Cannabinoid Receptor)
9. Amino Acid Transport Systems (Amino Acid Transporter)
10. Nerve Growth Factor (NGF)