A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
Also Known As:
TRP Cation Channels; TRP Membrane Proteins; Transient Receptor Potential Cation Channels; Cation Channel, TRP; Cation Channels, TRP; Channel, TRP Cation; Channels, TRP Cation; Membrane Proteins, TRP; Proteins, TRP Membrane; TRP Cation Channel; Transient Receptor Potential Cation Channel; Transient Receptor Potential Channel